Duphalac syrup 667mg ml 15ml N10,
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Active ingredients
Lactulose
Release form
Syrup
Composition
In 100 ml: lactulose 66.7 g. Excipients: purified water - up to 100 ml.
Pharmacological effect
Laxative. Causes a change in the flora of the colon (an increase in the number of lactobacilli), which leads to an increase in acidity in the lumen of the colon and stimulates its motility. Along with this, the volume increases and the softening of the feces occurs. As a result, a laxative effect develops, without direct influence on the mucous membrane and smooth muscles of the colon. Under the action of lactulose, ammonia is also absorbed in the colon, reducing the formation of nitrogen-containing toxic substances in its proximal section and, accordingly, their absorption into the vena cava system. It has the ability to inhibit the growth of Salmonella in the colon. Does not reduce the absorption of vitamins and is not addictive. Practically not absorbed from the intestines.
Indications
Constipation, incl. chronic, during pregnancy, hemorrhoids. after surgery on the colon and / or in the anus, to prepare for surgery on the colon. to soften the stool (relief of defecation) with pain after removal of hemorrhoids. hepatic encephalopathy. hepatic precoma and coma.
Contraindications
Rectal bleeding. colo, ileostomy. suspected appendicitis. galactosemia. patients with lactose intolerance, lactase deficiency, glucose-galactose malabsorption. intestinal obstruction. hypersensitivity to lactulose.
Use during pregnancy and lactation
May be used during pregnancy and lactation (breastfeeding) according to indications.
Side effects
On the part of the digestive system: in the first days of reception, the appearance of flatulence is possible (usually gradually decreases and passes). when taken in doses exceeding the recommended, possible pain in the abdomen and diarrhea, which requires dose adjustment. rarely nausea. When used in high doses for a long time for the prevention and treatment of hepatic precoma and coma, diarrhea and impaired water-electrolyte metabolism are possible. From the nervous system: rarely - convulsions, headache, dizziness.Other: possible - allergic reactions. rarely - arrhythmias, myalgia, fatigue, weakness.
special instructions
On the part of the digestive system: in the first days of reception, the appearance of flatulence is possible (usually gradually decreases and passes). when taken in doses exceeding the recommended, possible pain in the abdomen and diarrhea, which requires dose adjustment. rarely nausea. When used in high doses for a long time for the prevention and treatment of hepatic precoma and coma, diarrhea and impaired water-electrolyte metabolism are possible. From the nervous system: rarely - convulsions, headache, dizziness. Other: possible - allergic reactions. rarely - arrhythmias, myalgia, fatigue, weakness.