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Active ingredients
Mometasone + Salicylic Acid
Release form
Ointment
Composition
Mometasone furoate 1 mg, salicylic acid 50 mg. Adjuvants: hexylene glycol 120 mg, propylene glycol stearate 20 mg, purified water 30 mg, vaseline 729 mg, beeswax white 50 mg.
Pharmacological effect
Mometasone furoate - glucocorticosteroid. It has anti-inflammatory, antipruritic and vasoconstrictive properties. In general, the mechanism of anti-inflammatory action of topical glucocorticosteroids is unclear. Glucocorticosteroids are believed to induce the release of proteins that inhibit phospholipase A2 and are commonly known as lipocortins. These proteins are believed to control the biosynthesis of such potent inflammatory mediators, like prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids under the action of phospholipase A2. In experiments in vitro, mometasone furoate was shown to be a powerful inhibitor of the synthesis of three cytokines involved in the development of the inflammatory process and its maintenance: interleukin-1 (IL-1), interleukin-6 (IL-6) and alpha-tumor necrosis factor (TNF-α). Salicylic acid causes exfoliation of the stratum corneum.
Pharmacokinetics
After a single topical ointment, about 1.5% of the applied dose is subjected to systemic absorption. The drug that enters the systemic circulation is excreted in the urine and feces.
Indications
For relieving inflammatory manifestations and hyperkeratosis: - in psoriasis; - in atopic dermatitis; - in seborrheic dermatitis.
Contraindications
- children's age (up to 12 years); - hypersensitivity to mometasone furoate, salicylic acid or to any other component of the drug; - bacterial, viral (herpes simplex, chicken pox, shingles) or fungal infections of the skin, rosacea, or perioral dermatitis, post-vaccination reactions, tuberculosis, syphilis.- it is not recommended to use with occlusive dressings, including diapers and plastic pants.- not applied to the face or in the groin and axillary hollows. Before making a decision on the appointment of Elocom ointment OM-S is necessary to assess the risk and the expected effect of the use of the drug in case of the following diseases: diabetes mellitus, inflammation of peripheral vessels, irritation or infection of the skin, as well as during pregnancy and lactation.
Precautionary measures
Use in childrenContraindicated in children under 12 years.
Use during pregnancy and lactation
Controlled studies of the drug during pregnancy has not been conducted. Elokom-S ointment can be used in pregnant women only if the expected benefit of treatment justifies the possible risk to the fetus. There is no information that local administration of glucocorticosteroids or salicylic acid can lead to systemic action and detection of the drug in breast milk. Since many drugs are excreted in breast milk, caution should be exercised when prescribing Elok-S ointment to lactating women.
Dosage and administration
Used externally. A thin layer of Elokom-S ointment should be applied to the affected skin 2 times / day: morning and evening; the maximum daily dose is 15 g.
Side effects
Mild or moderate burning sensation at the site of application of the ointment, itching, skin atrophy, peeling, irritation, skin maceration, dry skin, folliculitis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, the appearance of atrophic strips of skin, haemorrhea, secondary infections, hypertricosis. In children, in addition, it is possible to suppress the function of the hypothalamic-pituitary-adrenal system, including the development of Cushing's syndrome.
Overdose
Prolonged treatment with glucocorticosteroids, when applied topically in excess, can lead to suppression of the hypothalamic-pituitary-adrenal system and secondary adrenal insufficiency. If suppression of the hypothalamic-pituitary-adrenal system is observed, then the use of the ointment should be discontinued or the frequency of application should be reduced. In case of toxicity caused by salicylic acid, the use of Elok-C ointment should be stopped. The introduction of fluid contributes to the removal of salicylates from the body with urine. As necessary, you can assign oral or in / in the introduction of sodium bicarbonate and potassium salts.
Interaction with other drugs
In the local application of Elokom-S ointment, the presence of small amounts of salicylates in the blood plasma was noted. According to the data on the interaction of salicylates with other substances after ingestion or application to the skin,the effect of the following medicinal compounds may be changed: tolbutamide (butamide), methotrexate, heparin, pyrazinamide, uric acid excretion medications, and coumarin-type drugs. Other glucocorticosteroids and ammonium sulfate may affect salicylic acid content. Elokom-S ointment together with these compounds.
special instructions
Apply strictly on doctor's prescription in order to avoid complications. Appropriate precautions should be taken in case of applying ointment to large areas of the skin or intended long-term use of the drug. This is especially important in pediatrics. Due to the fact that the ratio of skin surface and body weight in children is higher than in adults, children more than adults are predisposed to suppress the hypothalamic-pituitary-adrenal system and develop Cushing syndrome in response to glucocorticosteroids. Children should receive the minimum number of glucocorticosteroids, necessary to achieve the effect. Long-term therapy with glucocorticosteroids can have an undesirable effect on the growth and development of children. Glucocorticosteroids can cause a change in the appearance of the affected skin, making it difficult to make a correct diagnosis. Ointment Elok-S cannot be used in ophthalmology. In case of irritation, including excessive dryness skin, you should stop using Elok-S ointment and prescribe appropriate treatment. If a concomitant skin infection develops, you should use the necessary ribkovoe or antibacterial agent. If a positive response to treatment is not achieved quickly, the use of Elok-S ointment should be interrupted until the infection is properly eliminated.