Buy Ferrum lek chewable tablets 100mg N30

Ferrum lek chewable pills 100mg N30

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Active ingredients

Iron (III) hydroxide polymaltozane

Release form

Pills

Composition

Active ingredient: iron (III) hydroxide polymaltozate 400 mg, in terms of iron - 100 mg. Auxiliary substances: macrogol 6000 - 37.0 mg; aspartame, 1.5 mg; chocolate flavoring - 0.6 mg; talc - 21.0 mg; dextrates - to obtain 730.0 mg. Concentration of active ingredient (mg): 100 mg

Pharmacological effect

Antianemic drug. in the preparation ferrum lek, iron is in the form of a complex compound of iron (iii) hydroxide polymaltozate. The molecular mass of the complex is so large (about 50 kDa) that its diffusion through the mucous membrane of the gastrointestinal tract is 40 times slower than the diffusion of ferrous iron. The complex is stable and under physiological conditions does not release iron ions. the iron of the multinuclear active zones of the complex is bound in a structure similar to the structure of the natural iron compound - ferritin. due to this similarity, the iron of this complex is absorbed only by active absorption. iron-binding proteins located on the surface of the intestinal epithelium absorb iron (iii) from the complex through a competitive exchange of ligands. absorbed iron is mainly deposited in the liver, where it binds to ferritin. later in the bone marrow, it is incorporated into the hemoglobin. The complex of iron (iii) hydroxide polymaltozate does not possess the prooxidant properties inherent in the salts of iron (ii).

Pharmacokinetics

Studies using the double isotope method (55Fe and 59Fe) have shown that iron absorption, measured by the level of hemoglobin in red blood cells, is inversely proportional to the dose taken (the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of iron absorbed (the greater the iron deficiency, the better the absorption). Most iron is absorbed in the duodenum and jejunum. The remaining (unabsorbed) iron is excreted in the feces. Its excretion with peeling epithelium cells of the gastrointestinal tract and skin, as well as with sweat, bile and urine is approximately 1 mg of iron / day. In women, menstruation causes an additional loss of iron, which must be taken into account.

Indications

• treatment of latent iron deficiency; • treatment of iron deficiency anemia; • prevention of iron deficiency during pregnancy.

Contraindications

• hypersensitivity to the components of the drug, • iron overload of the body (for example, in cases of hemochromatosis, hemosiderosis); • impaired iron utilization (for example, anemia caused by lead intoxication, sideroachrestic anemia, thalassemia); • anemia not related to iron deficiency (for example, hemolytic anemia, megaloblastic anemia due to vitamin B12 deficiency); • children's age up to 12 years (for this dosage form).

Precautionary measures

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.

Use during pregnancy and lactation

In the course of controlled studies with the use of the drug in the II and III trimesters of pregnancy, there was no negative effect on the mother or fetus. No adverse effects on the fetus were detected when using the drug in the first trimester of pregnancy.

Dosage and administration

Inside, pills can be chewed or swallowed whole. The drug is recommended to be taken during or immediately after a meal. The daily dose can be divided into several doses. Doses and duration of treatment depend on the degree of iron deficiency. Latent iron deficiency The duration of treatment is about 1-2 months. Children over 12 years old, adults and mothers who breast feed a child 1 chewable tablet (100 mg) Ferrum Lek per day. Iron deficiency anemia The duration of treatment is about 3-5 months. After the hemoglobin concentration is normalized, the drug should be continued for a few more weeks in order to replenish iron stores in the body. Children over 12 years old, adults and mothers who breastfeed a child 1-3 chewable pills (100-300 mg) Ferrum Lek per day. Pregnant women Latent iron deficiency and prevention of iron deficiency 1 chewable tablet (100 mg) Ferrum Lek per day. Iron deficiency anemia 2-3 chewable pills (200-300 mg) Ferrum Lek per day until hemoglobin concentration is normalized. After that, you should continue to take 1 chewable tablet per day, at least until the end of pregnancy to replenish iron stores in the body.

Side effects

Ferrum Lek is generally well tolerated.Side effects are predominantly light and transient. According to the World Health Organization (WHO), adverse reactions are classified according to their development frequency as follows: very often (≥1 / 10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, < 1/100), rarely (≥1 / 10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to the available data it was not possible to establish the frequency of occurrence. Nervous system disorders are rare: headache. Violations of the gastrointestinal tract is very often: discoloration of feces (due to the removal of non-absorbed iron, has no clinical significance); often: diarrhea, nausea, dyspepsia; very rarely: pain in the abdomen, constipation, vomiting, discoloration of tooth enamel. Violations of the skin and subcutaneous tissues are very rare: urticaria, rash, itching of the skin. If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.

Overdose

In cases of overdose for oral administration of Ferrum Lek, no signs of intoxication or signs of excessive iron intake have been described so far, since iron from the active substance is not present in the gastrointestinal tract in free form and is not absorbed by passive diffusion.

Interaction with other drugs

No interaction with other drugs or food products has been noted.

special instructions

Chewable pills and syrup do not cause staining of tooth enamel. When administering Ferum Lek, patients with diabetes should take into account that 1 tab. chewing and 1 ml of syrup contains 0.04 XE. In cases of anemia caused by an infectious or malignant disease, iron accumulates in the reticulo-endothelial system, from which it is mobilized and utilized only after the main disease has been cured. (selectively to hemoglobin). Use in pediatrics Children under the age of 12 years due to the need to prescribe the drug in low doses, preferably used in the form of syrup. Effects on Nost to drive vehicles and management mehanizmamiNe effect on the ability to concentrate.

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