Flemoxin SoluTab pills soluble 250 mg 20 pcs
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Active ingredients
Amoxicillin
Release form
Non-dispersed Tablets
Composition
Active ingredient: Amoxicillin Concentration of active ingredient (mg): 500 mg
Pharmacological effect
A bactericidal, acid-resistant broad-spectrum antibiotic from the group of semi-synthetic penicillins. disrupts the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria. is active against gram-positive and gram-negative microorganisms: streptococcus pyogenes, streptococcus pneumoniae, clostridium tetani, clostridium welchii, neisseria gonorrhoe, and werech, as a part of our structures, as a matter of us, as a matter of us, as a matter of ashes, IU, Ich, Ich, Ich. β-lactamase), bacillus anthracis, listeria monocytogenes, helicobacter pylori. , proteus spp. (indole-positive strains), serratia spp., enterobacter spp. strains producing penicillinase are resistant to amoxicillin.
Pharmacokinetics
After ingestion, amoxicillin is absorbed quickly and almost completely (93%), it is not destroyed in the acidic environment of the stomach. Eating almost no effect on the absorption of the drug. After ingestion of 500 mg of amoxicillin Cmax of the active substance, which is 5 μg / ml, is noted in the blood plasma after 2 hours. Increasing or decreasing the dose of the drug by 2 times Cmax in the blood plasma also changes by 2 times. The distribution of plasma protein is 17%. . Amoxicillin penetrates mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in the blood plasma by 2-4 times. In amniotic fluid and umbilical cord vessels, amoxicillin concentration is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicillin poorly penetrates the BBB; however, in inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma. Small amounts are excreted in breast milk. Metabolism Amoxicillin is partially metabolized in the liver, most of its metabolites are not microbiologically active. form (by canalicular excretion - 80% and glomerular filtration - 20%), by the liver - 10-20%. In the absence of renal impairment, T1 / 2 amoxicillin is 1-1.5 h.In premature babies, newborns and children younger than 6 months - 3-4 hours. Pharmacokinetics in special clinical situations T1 / 2 of amoxicillin does not change if the liver function is abnormal. When kidney function is abnormal (CK ≤ 15 ml / min) anuria 8.5 parts Amoxicillin is removed from the body during hemodialysis.
Indications
Infectious and inflammatory diseases caused by susceptible microorganisms: respiratory infections, infections of the urogenital system, infections of the digestive tract, infections of the skin and soft tissues.
Contraindications
hypersensitivity to the drug and other beta-lactam antibiotics
Precautionary measures
The drug should be stored out of reach of children at a temperature not exceeding 25 ° C.
Use during pregnancy and lactation
Use of the drug Flemoxin Solutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother exceeds the risk of side effects in the fetus and infant. Small amounts of amoxicillin are excreted in breast milk, which can lead to the development of sensitization in the infant baby
Dosage and administration
Inside (oral) The dose is set individually, taking into account the severity of the disease, the patient's age. In the case of infectious and inflammatory diseases of mild and moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years old are prescribed 500-750 mg 2 times / day or 375-500 mg 3 times / day. Children from 3 to 10 years old are prescribed 375 mg 2 times / day or 250 mg 3 times / day. Children from 1 to 3 years old should be prescribed 250 mg 2 times / day or 125 mg 3 times / day. The daily dose of the drug for children (including children up to 1 year) is 30-60 mg / kg / day, divided into 2-3 doses. In the treatment of severe infections, as well as in infections with hard-to-reach foci of infection (for example, acute otitis media), three times the drug is preferred. In chronic diseases, recurrent infections, severe infections, the dose of the drug can be increased: adults are prescribed 750 mg - 1 g 3 times / day; children up to 60 mg / kg / day, divided into 3 doses. In acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 administration in combination with 1 g of probenecid.Patients with impaired renal function with creatinine clearance below 10 ml / min reduce the dose of the drug by 15-50%. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed, washed down with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or a suspension (in 100 ml), with a pleasant fruity taste. In case of mild to moderate infections, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days. In the treatment of chronic diseases, infections of the severe course of the dose of the drug should be determined by the clinical picture of the disease. The drug should be continued for 48 hours after the disappearance of the symptoms of the disease.
Side effects
On the part of the digestive tract: rarely - a change in taste, nausea, vomiting, diarrhea; in some cases - a moderate increase in the activity of “liver” transaminases, extremely rarely - pseudomembranous and hemorrhagic colitis. On the part of the urinary system: extremely rare - the development of interstitial nephritis. On the part of the hematopoietic system: agranulocytosis, neutropenia, thrombocytopenia, hemolytic anemia are possible, but they are also extremely rare. Side effects from the nervous system when using amoxicillin in the dosage form of the tablet dispersible are not registered. Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash; rarely, erythema multiforme exudative (Stevens-Johnson syndrome); in some cases - anaphylactic shock, angioedema.
Overdose
Symptoms: GIT dysfunction - nausea, vomiting, diarrhea; a consequence of vomiting and diarrhea can be a violation of water and electrolyte balance. Treatment: prescribe gastric lavage, activated carbon, saline laxatives; apply measures to maintain water and electrolyte balance, hemodialysis.
Interaction with other drugs
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone inhibit the tubular secretion of penicillins, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in the blood plasma.aminoglycides, cefalosporins, vanomitsin, rifampicin with a simultaneous intake of synergism. It is possible to antagonize the intake of some bacteriostatic preparations (for example, chloramphenicol), sulphrine, and sulphate. , laxative drugs, aminoglycosides, food reduce absorption. Ascorbic acid increases absorption. Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); enhances digoxin absorption. Simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.
special instructions
Prescribing the drug to patients with infectious mononucleosis and lymphocytic leukemia should be used with caution, since the appearance of a non-allergic eye is high. The presence of erythroderma in history does not constitute a contraindication for the administration of the drug Flemoxin Solutab. colitis is an indication for discontinuation of the drug. During course treatment, it is necessary to monitor the condition functions of the blood-forming organs, liver and kidneys. Superinfection is possible due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibiotic therapy. When treating mild diarrhea during the course of treatment, avoid diarrheal drugs that reduce intestinal motility; kaolin or attapulgite-containing anti-diarrhea drugs may be used. Treatment continues for another 48-72 hours after the disappearance of the clinical symptoms of the disease. If estrogen-containing oral contraceptives and amoxicillin are used at the same time, other or additional contraceptive methods should be used, if possible. Effect on ability to drive and control mechanisms No adverse effects of the drug on the ability to to the management of vehicles or work with mechanisms.