Furamag capsules 50 mg 30 pcs
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Active ingredients
Furazidin
Release form
Capsules
Composition
1 capsule contains: Active substance: furazidin potassium 50 mg, which corresponds to the furazidina content of 43.7 mg. Adjuvants: potassium carbonate - 12.6 mg, magnesium hydroxycarbonate - 50 mg, talc - 3 mg. Composition of gelatin capsule No3: gelatin - 97.48%, dye quinoline yellow (E104) - 1.2%, titanium dioxide (E171) - 1.32%.
Pharmacological effect
An antimicrobial agent of broad-spectrum, belonging to the group of nitrofurans. The resistance to Furamag develops slowly and does not reach a high degree. It is active against gram-positive cocci: Streptococcus spp., Staphylococcus spp .; Gram-negative bacilli: Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Klebsiella spp., Enterobacter spp .; protozoa: Lamblia intestinalis and other microorganisms resistant to antibiotics. Regarding Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Bacterium citrovorum, Proteus mirabilis, Proteus morganii Furamag, compared to other nitrofurans, more active. faecalis, Staphylococcus spp. compared with other groups of antibacterial drugs. Against most bacteria, the bacteriostatic concentration ranges from 1: 100,000 to 1: 200,000. The bactericidal concentration is about 2 times greater. Under the influence of nitrofurans, microorganisms suppress the respiratory chain and the tricarboxylic acid cycle (Krebs cycle). ), as well as the inhibition of other biochemical processes of microorganisms, resulting in the destruction of their membrane or cytoplasmic membrane. As a result of the action of nitrofurans microorganism s allocate fewer toxins, and therefore the improvement of the general state of the patient may still be expressed to suppress the growth of the microflora. Nitrofurans, unlike many other antimicrobial agents, not only do not inhibit the body's immune system, but rather activate it: they increase the complement titer and the ability of leukocytes to phagocytose microorganisms. At therapeutic doses, nitrofurans stimulate leukopoiesis.
Pharmacokinetics
AbsorptionAfter taking the drug inside, furazidin is absorbed in the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segments by 2 and 4 times, respectively (should be considered when simultaneously treating urogenital infections and diseases of the gastrointestinal tract, in particular chronic enteritis).Nitrofurans are poorly absorbed from the colon. Cmax in the blood plasma persists from 3 to 7 or 8 hours, furazidin is detected in urine after 3-4 hours. Being a mixture of potassium salt of furazidine and magnesium carbonate in the ratio of 1: 1, Furamag when administered orally has higher bioavailability than simple furazidin (after taking the Furamag capsule in the acidic environment of the stomach, furazidine potassium is not converted into poorly soluble furazidin). Distribution In the body, furazidine is evenly distributed. It is clinically important to have a high content of the active substance in the lymph (delaying the spread of infection through the lymphatic ducts). In bile, its concentration is several times higher than in serum, and in cerebrospinal fluid - several times lower than in serum. In saliva, the content of furazidine is 30% of its concentration in serum. The concentration of furazidine in the blood and tissues is relatively low, which is associated with its rapid release, while the concentration in the urine is much higher than in the blood. Metabolism Slightly biotransformed (<10%). DiversionUnlike nitrofurantoin (furadonin), after taking Furamag, urine does not is changing. Four hours after taking the drug, the concentration of furazidine in the urine significantly exceeds the concentration that is formed after taking the same dose of furagin. It is excreted by the kidneys by glomerular filtration and tubular secretion (85%), and is partially reabsorbed in the tubules. At low concentrations of furazidine in the urine, filtration and secretion prevail, at high concentrations, secretion decreases and reabsorption increases. Furazidin, being a weak acid, does not dissociate in acidic urine, undergoes intensive reabsorption, which may enhance the development of systemic side effects. With alkaline urine, the excretion of furazidine increases. Pharmacokinetics in special clinical situations. With a decrease in renal excretory function, the intensity of metabolism increases.
Indications
Infections caused by microorganisms sensitive to furazidine: - Urogenital infections (acute cystitis, urethritis, pyelonephritis); - Gynecologic infections; - Infections of the skin and soft tissues; - Severe infected burns; - With prophylactic purposes for urological operations (including cystoscopy , catheterization).
Contraindications
- Chronic renal failure severe; - Pregnancy; - Lactation period (breastfeeding); - Children under 3 years old (for this dosage form); - Hypersensitivity to nitrofuran group drugs. With caution, use the drug with a deficiency of glucose-6-phosphate dehydrogenase .
Use during pregnancy and lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Dosage and administration
The drug should be taken orally after meals with a large amount of liquid. Adults are prescribed 50-100 mg 3 times / day. Children should be prescribed 25-50 mg 3 times / day (but not more than 5 mg / kg of body weight per day). Course treatment 7-10 days. If necessary, repeat the course of treatment should take a break for 10-15 days. To prevent infection during urological operations, cystoscopy, catheterization, etc. the drug is prescribed to adults on 50 mg, to children - 25 mg once a day 30 minutes before the procedure. In case of skipping the drug, the next dose should be taken at the usual time. Do not take double the dose to compensate for the missed dose.
Side effects
On the part of the digestive system: rarely - nausea, vomiting, loss of appetite, abnormal liver function. On the part of the central nervous system and peripheral nervous system: rarely - headache, dizziness, polyneuritis. Allergic reactions: rarely - skin rash (including papular rash ). Furamag low toxic.
Overdose
Symptoms: manifestations of a neurotoxic nature, ataxia, tremor. Treatment: drink large amounts of fluids. For the relief of acute symptoms, antihistamines are used. For the prevention of neuritis it is possible to prescribe vitamins (thiamine bromide).
Interaction with other drugs
Furamag should not be used simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of hematopoiesis is increased). It is not recommended to prescribe drugs capable of acidifying urine (including ascorbic acid, calcium chloride) simultaneously with nitrofurans.
special instructions
To reduce the likelihood of side effects Furamag wash down with a large amount of fluid. If side effects occur, use of the drug should be discontinued (toxic effects are more common in patients with reduced renal excretory function). The patient should inform the doctor of any side effects that occur during drug treatment. the period of treatment the patient is recommended to refrain from the use of alcoholic beverages,since it is possible to increase the side effects. The effect on the ability to drive motor vehicles and control mechanisms The impact on the ability to drive motor vehicles and control mechanisms is not noted.