Ibufen Susp. 100mg 5ml 100g orange spoon
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Description
Ibufen suspension - for children has antipyretic, analgesic and anti-inflammatory effect.
Active ingredients
Ibuprofen
Release form
Suspension
Composition
Active ingredient: ibuprofen. Auxiliary substances: cremophor RH-40, sodium phosphate dihydrate, magnesium and aluminum silicate, sucrose, glycerin, propylene glycol, methylhydroxybenzoate (E 218) and propylhydroxybenzoate (E 216), citric acid monohydrate, sodium hydroxybenzoate, sodium citrate, propylhydroxybenzoate (E 216), sodium monohydrate, sodium hydroxybenzoate, citric acid, sodium hydroxybenzoate, sodium citrate, sodium hydrochloride, sodium silicate, sodium sulfate, sodium hydrochloride, sodium silicate, sodium citrate, sodium hydroxybenzoate (E 216), citric acid monohydrate, sodium hydroxide benzate, E 216 orange oil, ethanol, isopropyl alcohol), orange-yellow dye, purified water.
Pharmacological effect
Ibufen is classified as a non-steroidal anti-inflammatory pharmaceutical drug that has analgesic and antipyretic properties. The active component of the drug is ibuprofen. Its mechanism of action lies in the inhibition of the enzyme cyclooxygenase, which play an important role in the process of arachidonic acid metabolism, which leads to a decrease in the synthesis of prostaglandins. In response to these effects, the intensity of the inflammatory process decreases, since prostaglandins are local mediators of this pathological process. Body temperature is normalized, as the stimulating effects of the temperature center of the brain are prevented, and the generation of pain impulses in the nerve trunks from the pathophysiological focus of the disease is reduced. The analgesic properties of the active ingredient are also partly associated with a decrease in the production of prostaglandins of classes E, F, I. Complementing this action is a decrease in the concentration of biogenic amines and a change in the sensitivity of the receptors of the nociceptive system. The analgesic effect of the drug in inflammatory pathology is most pronounced, when the amount of all the listed substances is increased due to the damaging factor. The antipyretic and analgesic effect develops much faster than the anti-inflammatory effect, since smaller doses of the pharmaceutical preparation are required to stop these pathological manifestations. Inhibition of inflammatory processes is observed only for 5-7 days of conservative sanation of the pathophysiological process.
Pharmacokinetics
More than 80% of the active ingredients are absorbed from the gastrointestinal tract. The time to reach the plasma concentration depends on the meal: on an empty stomach, the maximum amount of active substances in the blood is observed after 45 minutes, and after eating only 1.5-2.5 hours. In the bloodstream, the components of a pharmaceutical preparation are capable of binding to plasma proteins (mainly albumin) by about 90%, which allows them to circulate in the body for a relatively long period of time. The active substances penetrate slowly into the joint cavity - the maximum concentration in the synovial fluid is reached 2-3 hours after the use of a pharmaceutical preparation, however, they can linger in this physiological medium of the body longer than in the blood plasma. Metabolized drug mainly in the liver, undergoing pre and post systemic treatment. After absorption of most of the drug (about 60%), the pharmacologically inactive R-form of Ibuprofen is transformed into the active S-form under the influence of internal factors of the body. 60-90% of the dose taken out by the kidneys in the form of metabolic products with glucuronic acid. To a lesser extent, the pharmaceutical preparation is excreted in the bile and only 1% in unchanged form. Ibuprofen kinetics is biphasic in nature, and the half-life is 2-2.5 hours. A single dose is completely excreted from the body within 24 hours. Ibufen effect as an antipyretic, develops 30 minutes after taking the drug and lasts about 6-8 hours, depending on the individual indicators of metabolism.
Indications
Ibuprofen, the main active ingredient of a pharmaceutical preparation, has a wide spectrum of pharmacological action, therefore it can be used in two ways. First of all, the scope of the drug covers antipyretic abilities and it is prescribed in the following situations: catarrhal diseases, acute respiratory viral pathologies, flu, sore throat (pharyngitis), children's infectious diseases that are accompanied by intense fever, post-vaccination reactions. Ibufen can also be used as a painkiller for such pathological conditions,such as: toothache (including those caused by inflammatory processes), headache and migraines, neuralgia, algomenorrhea, muscle and joint pain (juvenile or chronic, gouty or psoriatic arthritis, osteochondrosis, ankylosing spondylitis - Bechterew's disease, joint disease with systemic lupus and so on), neuralgic amyotrophy - personage-Turner's disease, teething, accompanied by pain, with all sorts of injuries, thermal and electric burns.
Contraindications
Individual hypersensitivity, acquired or hereditary intolerance to composite components of the pharmaceutical and ibuprofen in particular aspirin triad ( "Aspirin asthma") - the simultaneous development of bronchospasm, urticaria and allergic rhinitis in treating not narcotic analgesic, malabsorption of carbohydrate type glucose-galactose malabsorption or deficiency of glucose-6-dephosphate dehydrogenase, peptic ulcer of the duodenum or stomach, a tendency to frequent hemo rash, impaired plasma or platelet coagulation (including hereditary pathologies such as hemophilia and hypocoagulation syndrome), hemorrhagic diathesis, organic lesions of the liver or kidneys in severe stages of the pathological process, the third trimester of pregnancy, severe heart failure (especially in the decompensated stage ), arterial hypertension, angioedema, angioedema of the angioedema, polypous growths in the nasal cavity, in the pediatric department, the drug is used only according to after reaching the age of 6 months and body weight more than 7 kg. There are also a number of conditions when the use of the drug is recommended only under the supervision of qualified medical personnel and regular diagnostic tests (for example, during inpatient treatment in the relevant institution): ulcerative colitis, Crohn's disease , dehydration and eksikoz, chronic diseases of the liver, kidneys or heart, if in the history of the patient's life there is information about a previous gastric ulcer or duodenal ulcers Noah intestine, recent surgical intervention.
Use during pregnancy and lactation
The use of the drug in the third trimester of the pregnancy period is strictly contraindicated. Clinical research on the effect of the drug on the organism of the future mother and child in the first and second trimester has not been conducted, however, based on its effects in the later months of this critical period, the use of the drug is not highly recommended. There is currently no reliable data on the effects of Ibufen in the period of lactation. In case of an acute need for the use of a pharmaceutical product, you should always consult with your doctor. As a rule, the question of stopping further breastfeeding is raised, so as not to harm the young child's body.
Dosage and administration
The average single dose for adults is 5-10 mg per 1 kg of body weight, repeated 3-4 times a day. The maximum daily amount of the drug should not exceed 30 mg per 1 kg of patient weight. A course of conservative therapy is prescribed individually by the attending physician, since it must be consistent with the indications for treatment and regular diagnostic indicators of the body. Ipufen syrup for children is used in pediatric practice, the instruction for which prescribes a strict dosage of the pharmaceutical preparation based on the child’s age and body weight (for children who take solid food, the syrup can be replaced by pills, because the amount of the substance taken is indicated in ml and in mg, depending on the form drug). From 6 months to 1 year with a mass of 7-9 kg - 2.5 ml (50 mg) 3 times in 24 hours, taking into account the maximum daily concentration, which is 7.5 ml (150 mg). 1-3 years old and a child's weight of 10-15 kg is the same amount as in the age group from 6 months to a year, but 3-4 times a day and the maximum amount of the drug can reach 10 ml (200 mg). At the age of 3-6 years and with a patient weight of 16-20 kg, the dose taken is increased to 5 ml (100 mg) 4 times a day with the maximum amount of the drug - 20 ml (400 mg). 9-12 years old and weight from 31 to 41 kg - children's syrup is used in an amount of 10 ml (200 mg) 3 times a day with an extreme dosage of 30 ml (600 mg). At the age of 12 years and body weight over 41 kg it is allowed to use 10 ml (200 mg). Children's drug is used 4 times a day. The maximum daily dose is 40 ml (800 mg).
Side effects
From the side of the central nervous system: dizziness, headache, sleep disturbance, anxiety, drowsiness, depression, reversible toxic amblyopia, blurred vision, diplopia - double vision. From the hematopoietic system: heart failure, tachycardia, thrombocytopenia, anemia, increased blood pressure, leukopenia (manifested as agranulocytosis). The digestive system: dyspeptic indigestion, diarrhea, loss of appetite, heartburn, constipation, flatulence, impaired liver excretory function, peptic ulcers of the stomach with a hemorrhagic outcome. Urinary system: acute renal failure, nephrotic syndrome, which is manifested mainly by edema, polyuria, cystitis, inflammation of the renal apparatus. Allergic reactions: pruritus and rash, bronchospastic syndrome, rhinitis, angioedema Quincke, Stevens-Johnson and Lyell's syndrome.
Overdose
In case of drug overdose, the following symptoms of increased concentration of the active ingredients of the drug are noted: abdominal pain, nausea and vomiting, inhibition of reaction, tinnitus, depression, disturbed sleep and wakefulness, metabolic acidosis, hemorrhagic diathesis, arterial hypotension, acute renal failure, arrhythmias type of tachycardia or bradycardia, depending on the individual predisposition to a change in the rhythm of the heart, atrial fibrillation, convulsions, apnea, coma (this adverse effects of treatment is especially true for children age category up to 5 years). There is no specific pharmacological analogue for Ibufen. If symptoms of overdose are present, symptomatic therapy is used. The following actions are shown: gastric lavage, correction of the acid-base state of the body, administration of enterosorbents led by activated carbon, alkaline nutrition, correction of blood pressure (depending on its level and rhythm of cardiac activity).
Interaction with other drugs
Ibufen should not be combined with other pharmaceutical products of this group, since acetylsalicylic acid, which is a component of most non-steroidal anti-inflammatory drugs, reduces the therapeutic effect and increases the possibility of side effects. Simultaneous use of diuretics on the background of Ibufen is also not recommended.Their interaction decreases the therapeutic effect of diuretic drugs and increases the risk of developing renal failure. The drug weakens the action of antihypertensive drugs, especially pharmaceuticals, whose mechanism of influence on blood pressure is the inhibition of the angiotensin-converting enzyme or the effect on beta-adrenergic receptors. Simultaneously, their excretion by the kidneys is reduced, which, with long-term therapy with these drugs, can lead to an overdose or a more active manifestation of side effects. Ibufen enhances the action of a number of medicinal substances: oral hypoglycemic agents used in diabetes mellitus (especially chemical derivatives of sulfonylurea and insulin), fibrinolytic agents and antiplatelet agents (the risk of hemorrhagic complications increases significantly), indirect anticoagulants (the therapeutic effects of influences depend on the effects on the effects of skin effects). liver function), the toxic effects of methotrexate and lithium preparations, increases the plasma concentration of digoxin ( the preparation has the ability to cumulate, because such a pharmacokinetic effect will certainly lead to severe overdose). Ibufen is metabolized preferentially in the liver, therefore inducers and inhibitors of microsomal oxidation significantly affect the cycle of its exchange. Such drugs as Phenythion, Tricyclic antidepressants, Ethanol, Barbiturates, Phenylbutazone, Zixorin, Rifampicin increase the production of hydroxylated active metabolites, which is manifested in an increased risk of developing hepatotoxic complications. Inhibitors of myosomal oxidation act exactly the opposite. Caffeine enhances the analgesic effect of ibuprofen.
special instructions
Under the action of gravity, the constituent components of the drug can be divided into surface floating layers and sediment at the bottom, therefore, before each use of the drug, it is necessary to shake the vial until a homogeneous suspension is obtained. With a long course of drug treatment, nonsteroidal anti-inflammatory drugs can cause gradual damage to the gastric mucosa, resulting in peptic ulcer or gastrointestinal bleeding. Therefore, it is recommended to conduct regular diagnostic tests of the acidic state of the gastric and intestinal juices.Pharmaceutical drug contains sugar, because patients with diabetes should take it with caution.