KromOGEKSAL spray for nasal application 15 ml
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Cromoglicic acid
Release form
Spray
Composition
Active ingredient: Cromoglicic acid. Auxiliary substances: benzalkonium chloride, sodium chloride, disodium edetate, liquid non-crystalline sorbitol, sodium dihydrogen phosphate dihydrate, disodium hydrogenphosphate dodecahydrate, water for injections. Active ingredient concentration (%): 2%
Pharmacological effect
Antiallergic agent, has a membrane stabilizing effect, blocks the flow of calcium ions into the fat cell, preventing its degranulation and the release of histamine, bradykinin, prostaglandins, leukotrienes (including slow-reacting substance) and other biologically active substances. The drug is most effective as a means of prevention. A noticeable clinical effect occurs after a few days or weeks of administration.
Pharmacokinetics
When administered intranasally, less than 7% is absorbed into the systemic circulation. Communication with plasma proteins - 65%. Not metabolized, excreted by the kidneys and through the intestine in unchanged form (approximately in equal amounts within 24 hours after application). T1 / 2 - 1.5 h. A part of the active substance is swallowed (about 1%) and is excreted through the gastrointestinal tract without significant absorption.
Indications
The drug is used in diseases that require the introduction of a fast-acting glucocorticosteroid, as well as in cases where oral administration of the drug is not possible: - endocrine diseases (acute insufficiency of the adrenal cortex, primary or secondary insufficiency of the adrenal cortex, congenital hyperplasia of the adrenal cortex, subacute thyroid gland. resistant to standard therapy; anaphylactic shock; - swelling of the brain (with a brain tumor, traumatic brain injury, neurosurgical intervention, cerebral hemorrhage, encephalitis, meningitis, radiation damage); - asthmatic status; severe bronchospasm (exacerbation of bronchial asthma, chronic obstructive bronchitis); severe allergic reactions; rheumatic diseases; systemic diseases of the connective tissue; acute severe dermatosis; malignant diseases (palliative treatment of leukemia and lymphoma in adult patients; acute leukemia in children; hypercalcemia in patientswith malignant tumors, if oral treatment is not possible arthritis of various etiologies, osteoarthritis, acute and subacute bursitis, acute tendovaginitis, epicondylitis, synovitis; - local application (in the area of pathological mations): keloids, discoid lupus erythematosus, granuloma annulare.
Contraindications
Hypersensitivity to sodium cromoglycate or to any other component of the drug; child's age up to 5 years pregnancy and lactation
Use during pregnancy and lactation
If the irritation or burning sensation of the mucous membrane of the nasal cavity does not go away or increases, it is necessary to stop treatment.
Dosage and administration
Intranasal. Adults and children over 5 years old are advised to administer 1 aerosol dose (2.8 mg of sodium cromoglycate) 4 times a day into each nasal passage. If necessary, you can apply 1 aerosol dose up to a maximum of 6 times (maximum - 16.8 mg) per day in each nasal passage. After achieving a therapeutic effect, the frequency of use of Kromohexal can be reduced and the drug can be used only when in contact with allergens (house dust, fungal spores, pollen). The course of treatment is 4 weeks. Cancellation should be done gradually over 1 week. To administer the drug, remove the protective cap, insert the spray device into the nostril, and press the spray mechanism tightly. When using the bottle for the first time, press the spray mechanism several times until liquid droplets appear.
Side effects
Cromoglycic acid may increase the effectiveness of H1-histamine blockers.
Overdose
On the part of the respiratory system: irritation or burning of the mucous membrane of the nasal cavity, frequent sneezing, coughing, rhinorrhea, rarely - nosebleeds. Allergic reactions: urticaria, itchy skin, skin rash, swelling of the face, lips or eyelids, shortness of breath, difficulty swallowing. Other: unpleasant taste, headache.
Interaction with other drugs
Precautionary measures
special instructions
Data overdose of the drug is not available.