Kvamatel pills 40 mg 14 pcs
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Active ingredients
Famotidine
Release form
Pills
Composition
Famotidine 40 mg Auxiliary substances: colloidal silicon dioxide - 1 mg, magnesium stearate - 2 mg, povidone K90 - 4 mg, sodium carboxymethyl starch (type A) - 6 mg, talc - 6 mg, corn starch - 51 mg, lactose monohydrate - 90 mg. The composition of the film shell: iron oxide red - 0.024 mg, colloidal silicon dioxide - 0.088 mg, titanium dioxide - 0.276 mg, macrogol 6000 - 0.499 mg, sepifilm 003 - 6.613 mg (macrogol-40 stearate (type I) - 8-12%, microcrystalline cellulose - 35-45%, hypromellose - 45-55%).
Pharmacological effect
Kvamatel - histamine H2-receptor blocker. Reduces the basal and stimulated gastrin, pentagastrin, betazol, caffeine, histamine, acetylcholine and physiological vagal reflex secretion of hydrochloric acid. This increases the pH and decreases the activity of pepsin. Practically does not affect gastrin levels on an empty stomach and after meals. It does not affect gastric motility, exocrine activity of the pancreas, blood circulation in the portal system, hormone levels, does not have an anti-androgenic effect. Famotidine has little effect on liver microsomal enzymes. After taking the drug inside the action occurs within 1 hour, the maximum action - 3 hours after administration, the duration of the effect varies from 12-24 hours, depending on the dose. The preparation in the form of a lyophilisate for preparing a solution for intravenous administration after administration in a single dose of 20 or 40 mg in the evening suppresses basal and nocturnal secretion for 10–12 hours.
Indications
peptic ulcer of the duodenum and stomach in the acute phase, prevention of relapse. treatment and prevention of symptomatic gastric and duodenal ulcers (associated with the use of NSAIDs, stress, postoperative). erosive gastroduodenitis. functional dyspepsia associated with increased gastric secretion. reflux esophagitis. Zollinger-Ellison syndrome. prevention of recurrence of bleeding from the upper GI tract. prevention of gastric juice aspiration during general anesthesia (Mendelssohn's syndrome).
Contraindications
pregnancy lactation period (breastfeeding). childhood . hypersensitivity to the drug. hypersensitivity to other histamine H2 receptor blockers.
Use during pregnancy and lactation
The drug is contraindicated for use in pregnancy. If necessary, the use of the drug during lactation breastfeeding should be discontinued.
Dosage and administration
When gastric ulcer and duodenal ulcer in the acute phase of Kvamatel prescribed in a dose of 40 mg 1 time per day before bedtime or 20 mg 2 times a day, morning and evening. If necessary, the daily dose can be increased to 80-160 mg. The duration of treatment is an average of 4-8 weeks. In order to prevent acute gastric ulcer and duodenal ulcer. Kvamatel prescribed in a dose of 20 mg 1 time per day before bedtime. When reflux esophagitis drug is prescribed in a dose of 20 mg 2 times a day (morning and evening) for 6 weeks. if necessary, 40 mg 2 times a day. With Zollinger-Ellison syndrome, the initial dose is 20-40 mg every 6 hours. if necessary, the daily dose can be increased to 240-480 mg. The duration of the drug depends on the clinical condition of the patient. In order to prevent aspiration of gastric contents during general anesthesia, Quamel is prescribed in a dose of 40 mg on the eve of the operation and / or in the morning on the day of surgery.
Side effects
On the part of the digestive system: dry mouth, nausea, vomiting, abdominal pain, flatulence, constipation, diarrhea, loss of appetite. increased activity of liver transaminases, hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis. On the part of the blood system: very rarely - agranulocytosis, pancytopenia, leukopenia, thrombocytopenia, hypo- or aplasia of the bone marrow. Allergic reactions: urticaria, skin rash, itching, bronchospasm, angioedema, anaphylactic shock. Since the cardiovascular system: arrhythmia, bradycardia, AV-blockade, lowering blood pressure. From the side of the central nervous system: headache, dizziness, drowsiness, hallucinations, confusion, fatigue, depression, agitation, anxiety. From the senses: decreased visual acuity, tinnitus. On the part of the reproductive system: with prolonged use in high doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido. On the part of the musculoskeletal system: arthralgia, muscle spasms. Dermatological reactions: alopecia, acne vulgaris, dry skin, toxic epidermal necrolysis. Other: fever.
special instructions
On the part of the digestive system: dry mouth, nausea, vomiting, abdominal pain, flatulence, constipation, diarrhea, loss of appetite. increased activity of liver transaminases, hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis. On the part of the blood system: very rarely - agranulocytosis, pancytopenia, leukopenia, thrombocytopenia, hypo- or aplasia of the bone marrow.Allergic reactions: urticaria, skin rash, itching, bronchospasm, angioedema, anaphylactic shock. Since the cardiovascular system: arrhythmia, bradycardia, AV-blockade, lowering blood pressure. From the side of the central nervous system: headache, dizziness, drowsiness, hallucinations, confusion, fatigue, depression, agitation, anxiety. From the senses: decreased visual acuity, tinnitus. On the part of the reproductive system: with prolonged use in high doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido. On the part of the musculoskeletal system: arthralgia, muscle spasms. Dermatological reactions: alopecia, acne vulgaris, dry skin, toxic epidermal necrolysis. Other: fever.