Metoprolol ratiopharm pills 100mg N30
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Active ingredients
Metoprolol
Release form
Pills
Composition
Metoprolol Tartrate 100 mg
Pharmacological effect
Cardioselective beta1-blocker without internal sympathomimetic activity. It has a hypotensive, antianginal and antiarrhythmic effect. It lowers the automatism of the sinus node, reduces heart rate, slows AV conductivity, reduces contractility and myocardial excitability, reduces cardiac output, reduces myocardial need for oxygen. Suppresses the stimulating effect of catecholamines on the heart during physical and psycho-emotional stress. It causes a hypotensive effect, which stabilizes by the end of the 2nd week of course application. With exertional angina, metoprolol reduces the frequency and severity of seizures. Normalizes heart rhythm in supraventricular tachycardia and atrial fibrillation. When myocardial infarction contributes to the limitation of the ischemic zone of the heart muscle and reduces the risk of fatal arrhythmias, reduces the likelihood of recurrence of myocardial infarction. When used in moderate therapeutic doses, it has a less pronounced effect on the smooth muscles of the bronchi and peripheral arteries than non-selective beta-blockers.
Indications
Arterial hypertension, prevention of strokes, heart rhythm disturbances (supraventricular tachycardia, extrasystole), secondary prophylaxis after myocardial infarction, hyperkinetic cardiac syndrome (including hyperthyroidism, NDC). Prevention of migraine attacks.
Contraindications
AV block II and III degree, sinoatrial block, bradycardia (HR less than 50 beats / min), SSSU, arterial hypotension, chronic heart failure IIB-III stage, acute heart failure, cardiogenic shock, metabolic acidosis, marked disorders of peripheral circulation, hypersensitivity to metoprolol.
Use during pregnancy and lactation
Use during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. Metoprolol penetrates the placental barrier. In connection with the possible development of bradycardia in the newborn, arterial hypotension,hypoglycemia and respiratory arrest metoprolol must be canceled 48-72 hours before the planned period of delivery. After delivery, it is necessary to ensure strict monitoring of the condition of the newborn within 48-72 hours. Metoprolol is excreted in small quantities with breast milk. Use during lactation is not recommended.
Dosage and administration
When ingested, the average dose is 100 mg / day in 1-2 doses. If necessary, the daily dose is gradually increased to 200 mg. With the / in the introduction of a single dose of 2-5 mg. in the absence of effect, repeated administration is possible after 5 minutes. Maximum doses: when ingested daily dose - 400 mg, with a / in the introduction of a single dose - 15-20 mg.
Side effects
Since the cardiovascular system: possible bradycardia, arterial hypotension, violations of AV-conduction, the appearance of symptoms of heart failure. On the part of the digestive system: at the beginning of therapy, dry mouth, nausea, vomiting, diarrhea, constipation. in some cases - abnormal liver function. On the part of the central nervous system and peripheral nervous system: weakness, fatigue, dizziness, headache, muscle cramps, feeling of cold and paresthesia in the extremities are possible at the beginning of the therapy. reduction of secretion of tear fluid, conjunctivitis, rhinitis, depression, sleep disturbances, nightmarish dreams are possible. From the hematopoietic system: in some cases - thrombocytopenia. On the part of the endocrine system: hypoglycemic states in patients with diabetes mellitus. On the part of the respiratory system: symptoms of bronchial obstruction are possible in predisposed patients. Allergic reactions: skin rash, itching.
special instructions
Since the cardiovascular system: possible bradycardia, arterial hypotension, violations of AV-conduction, the appearance of symptoms of heart failure. On the part of the digestive system: at the beginning of therapy, dry mouth, nausea, vomiting, diarrhea, constipation. in some cases - abnormal liver function. On the part of the central nervous system and peripheral nervous system: weakness, fatigue, dizziness, headache, muscle cramps, feeling of cold and paresthesia in the extremities are possible at the beginning of the therapy. reduction of secretion of tear fluid, conjunctivitis, rhinitis, depression, sleep disturbances, nightmarish dreams are possible. From the hematopoietic system: in some cases - thrombocytopenia. On the part of the endocrine system: hypoglycemic states in patients with diabetes mellitus.On the part of the respiratory system: symptoms of bronchial obstruction are possible in predisposed patients. Allergic reactions: skin rash, itching.