Buy Micrazim capsules 10,000 IU 20 pcs

Micrazim capsules 10,000 IU 20 pcs

Condition: New product

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$11.95

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Active ingredients

Pancreatin

Release form

Capsules

Composition

Pancreatin * 10 000 IU (125 mg), which corresponds to the activity: lipase 10 000 IU, amylase 7500 IU, proteases 520 IU. Auxiliary substances: enteric shell of pellets - a copolymer of methacrylic acid and ethyl acrylate (1: 1) (in the form of 30% dispersion , additionally containing polysorbate 80, sodium lauryl sulfate) - 25.3 mg, triethyl citrate - 5.1 mg, simethicone emulsion 30% (dry weight 32.6%) - 0.1%, including: precipitated colloidal silicon - 1.3%, suspended colloidal silicon - 0.9 %, methylcellulose - 2.5%, sorbic acid - 0.1%, water - 67.4%, talc - 12.6%. The composition of the capsule body: gelatin - up to 100%, water - 13-16%. Capsule body composition: gelatin - up to 100%, water - 13-16%, crimson dye (Ponce 4R) - 0.6666%, quinoline yellow dye - 0.1%, patented blue dye - 0.02%, titanium dioxide - 1.2999%.

Pharmacological effect

Micrasim - Pancreatin pellets in capsules. The preparation includes natural enzymes from the pancreas of animals - protease, lipase and amylase, which ensure the digestion of proteins, fats and carbohydrates in food. After taking Micrasim, the capsule quickly dissolves in the stomach, releasing pancreatin pellets coated with an enteric coating. Due to its small size, pellets are quickly and evenly mixed with food and simultaneously with the food lump easily penetrate the duodenum and then into the small intestine, where pancreatic enzymes are released and begin to act, contributing to the rapid and complete digestion of proteins, fats and carbohydrates. Rapid mixing of pancreatin pellets with stomach contents, their even distribution in it, simultaneous passage with chyme, as well as the preservation of enzymes before they begin to work in the intestine (due to the presence of enteric shell pellets), provide a higher digesting activity and maximum approximation of the drug to the natural process digestion. The enzymatic activity of the drug Micrazyme appears maximally 30 minutes after ingestion, which ensures the rapidity of the onset of the effect. After interaction with substrates, protease, lipase and amylase in the lower intestine lose their activity and, together with the intestinal contents, are removed from the body.

Pharmacokinetics

Micrazim is not absorbed from the gastrointestinal tract and acts only in the intestinal lumen.

Indications

- Replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreathectomy, condition after irradiation, dyspepsia, cystic fibrosis, flatulence, diarrhea of ​​non-infectious genesis — impaired food digestion (condition after resection of the stomach and small intestine): to improve digestion of food in people with normal The digestive tract in case of errors in the diet (the use of fatty foods, large amounts of food, irregular meals) and in violation of the chewing function, sedentary lifestyle, long-term immobilization — Remheld's syndrome (gastrocardial syndrome) —preparation for X-ray examination and ultrasound of the abdominal organs.

Contraindications

- acute pancreatitis; exacerbation of chronic pancreatitis; - individual intolerance to pancreatin or individual components of the drug.

Use during pregnancy and lactation

Data on the potential risks of using pancreatin during pregnancy and lactation are not available, therefore, the drug should be prescribed to pregnant women and nursing mothers only if the expected effect of the therapy outweighs the possible risks.

Dosage and administration

The dose of the drug is selected individually depending on the age, degree of symptoms and composition of the diet. Dose selection is carried out with the help of registered medicinal products Micrasim 10 000 IU and Micrazim 25 000 IU. Capsules are ingested, squeezed with a sufficient amount of non-alkaline liquid (water, fruit juices). If a single dose of the drug is more than 1 capsule, you should take half of the total number of capsules immediately before a meal, and the other half - while eating. If a single dose is 1 capsule, it should be taken with meals. For difficulty swallowing (for example, in children or the elderly), the capsule can be opened and taken directly in pellets, pre-mixed with liquid or liquid food (pH less than 5.0) that does not require chewing (applesauce, yogurt). The grinding or chewing of pellets, as well as adding them to food with a pH above 5.5, leads to the destruction of their shell, which protects from the action of gastric juice.Any mixture of pellets with food or liquid should be taken immediately after preparation. The permissible dose for children under the age of 1.5 years is 50,000 IU / day, older than 1.5 years is 100,000 IU / day. The duration of pancreatin intake can vary from a few days (indigestion) to several months or years (long-term substitution therapy). Replacement therapy for various types of exocrine pancreatic insufficiency. The dose is chosen individually and depends on the severity of exocrine insufficiency, individual eating habits and the age of the patient. Steatorrhea (more than 15 g of fat in the feces per day): In the presence of diarrhea, weight loss and no effect from diet therapy, 25,000 IU of lipase is prescribed at each meal. If necessary and well tolerated, the dose is increased to 30,000-35,000 IU of lipase per dose. A further increase in the dose, in most cases, does not improve the results of treatment and requires a review of the diagnosis, a decrease in the fat content in the diet, and / or an additional prescription of proton pump inhibitor drugs. When mild steatorrhea, not accompanied by diarrhea and weight loss, appoint from 10 000 IU to 25 000 IU of lipase per reception. Cystic fibrosis: The initial calculated dose for children under 4 years old is 1000 PIECES of lipase / kg body weight at each feeding, for children over the age of 4 years old - 500 PIECES of lipase / kg body weight at each meal. The dose should be selected individually, depending on the severity of the disease, the severity of steatorrhea and nutritional status. The maintenance dose for most patients should not exceed 10,000 IU of lipase / kg body weight per day.

Side effects

Possible: allergic reactions. Seldom: at use of drug in high doses diarrhea, nausea, constipations, discomfort in the epigastric region are observed. With prolonged use in high doses, the development of hyperuricuricuria, hyperuricemia.

Overdose

Symptoms: an increase in the content of uric acid in the urine (hyperuricuria) and blood (hyperuricemia); children have constipation. Treatment: removal of the drug, conducting symptomatic therapy.

Interaction with other drugs

With simultaneous use of pancreatin with iron preparations may decrease the absorption of the latter.

special instructions

Children and adults who have received high doses of pancreatin for a long time should be observed by a specialist. The main reasons for the ineffectiveness of enzyme therapy are the inactivation of enzymes in the duodenum as a result of acidification of its contents, concomitant diseases of the small intestine (helminthic invasions, dysbiosis), the failure of patients to follow the recommended treatment regimen, the use of enzymes that have lost their activity. Impact on the ability to drive motor vehicles and control mechanisms: There is no data on the effect of the drug on the ability to drive motor vehicles and perform work requiring increased concentration and psychomotor reactions.

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