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Active ingredients
Cinnarizine
Release form
Pills
Composition
Active ingredient: Cinnarizine (Cinnarizinum) Active ingredient concentration (mg): 25
Pharmacological effect
Selective blocker of slow calcium channels, reduces the entry of calcium ions into cells and reduces their content in the plasmolemm depot, reduces the tone of arteriole smooth muscle, enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, reduces their response to nutrients (adrenaline, norepinephrine, dopamine, angiotensin, vasopressin). It has a vasodilating effect (especially in relation to the vessels of the brain), without having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity. Increases muscle resistance to hypoxia.
Pharmacokinetics
The drug is resorbed in the stomach and intestines. Cmax in plasma after oral administration after 1-3 hours. The connection of cinnarizine with plasma proteins is 91%. Fully metabolized in the liver (via glucuronidation). T1 / 2 is 4 hours. Excreted in the form of metabolites: 1/3 by the kidneys, 2/3 through the intestines.
Indications
Adults Treatment of symptoms of cerebrovascular origin (dizziness, tinnitus, vascular headache, irritability, impaired memory and concentration of attention), vestibular disorders (including Meniere's disease; dizziness, tinnitus, nystagmus, nausea and vomiting of labyrinth origin ), prevention of kinetozov (road sickness - sea and air sickness), migraine (prevention of seizures); peripheral circulatory disorders (intermittent claudication, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders (including trophic and varicose ulcers), acrocyanosis, paresthesia, night cramps and coldness in the limbs). Children over 5 years old Prevention of kinetosis (road sickness - sea and air sickness)
Contraindications
Hypersensitivity, pregnancy, lactation. Age up to 5 years (efficacy and safety not established).
Precautionary measures
At the beginning of treatment, you should refrain from potentially hazardous activities that require increased concentration and psychomotor reactions, as well as alcohol intake.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy and during breastfeeding.
Dosage and administration
Inside, after eating. In violation of the blood circulation of the brain - 25-50 mg (1-2 pills) three times a day; in violation of the peripheral circulation - 50-75 mg (2-3 pills) three times a day; with vestibular disorders, 25 mg three times a day; in case of kinetosis (“road” disease): for adults - 25 mg per half hour before the road (if necessary, re-admission of 25 mg after 6 hours). The maximum dose of the drug should not exceed 225 mg (9 pills) per day. The dose for children from 5 to 12 years old is 14 doses recommended for adults, the dose for children over 12 years old corresponds to the dose recommended for adult patients. With a high sensitivity to the drug, treatment begins with 1/2 the dose, increasing it gradually. The course of treatment from several weeks to several months.
Side effects
On the part of the nervous system: drowsiness, fatigue, headache, extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia in elderly patients with prolonged treatment, in such cases, treatment should be stopped), depression. On the part of the digestive system: dry mouth, pain in the epigastric region, dyspepsia, cholestatic jaundice (extremely rare). On the part of the skin: sweating, the development of lupus-like syndrome, lichen planus (extremely rare), skin rash. Other: Allergic reactions, weight gain.
Overdose
The maximum recommended dose should not exceed 225 mg (9 tab.) Per day. There is no specific antidote. In case of overdose, symptomatic therapy is carried out: gastric lavage, taking activated charcoal.
Interaction with other drugs
Enhances the effect of alcohol and sedatives. When used simultaneously with nootropic, antihypertensive and vasodilators it enhances their effect, and when used simultaneously with drugs prescribed for arterial hypotension, it reduces their effect.
special instructions
Due to the presence of the antihistamine effect, Stugeron may affect the result of the athletes' anti-doping control (false positive result), and may also neutralize positive reactions during skin diagnostic tests (treatment should be canceled 4 days before the test) liver, kidney, pictures of peripheral blood. Patients suffering from Parkinson’s disease should be prescribed Stugeron only when May the benefits outweigh the potential risk of deterioration.