Tafen nasal spray nasal 200 doses
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Active ingredients
Budesonide
Release form
Spray
Composition
Active ingredient: Budesonide Concentration of active ingredient (mcg): 50 mcg
Pharmacological effect
Gx for intranasal use. has a pronounced anti-inflammatory and anti-allergic effect. when used in therapeutic doses has almost no resorptive effect. does not possess mineralocorticoid activity, is well tolerated with long-term treatment. the drug has an inhibitory effect on the release of inflammatory mediators, increases the synthesis of anti-inflammatory proteins, reduces the number of mast cells and eosinophilic granulocytes. budesonide reduces the release of toxic proteins from eosinophils, free radicals from macrophages and lymphokines from lymphocytes. it also reduces the binding of adhesive molecules to endothelial cells, thus reducing the influx of leukocytes to the site of allergic inflammation. budesonide increases the number of β-adrenergic receptors of smooth muscles. the drug inhibits the activity of phospholipase 2a, which leads to inhibition of the synthesis of prostaglandins, leukotrienes and puff, inducing an inflammatory response. budesonide also inhibits histamine synthesis, which leads to a decrease in its level in mast cells. Taphen nasal reduces the severity of symptoms in allergic rhinitis, suppresses the late and early phases of the allergic reaction and reduces inflammation in the upper respiratory tract. improvement is noted on 2-3 days after the start of treatment.
Pharmacokinetics
After inhalation, 400 μg of budesonide Cmax in plasma is reached within 0.7 hours and is 1 nmol / l. Only about 20% of the intranasally administered dose enters the systemic circulation. DistributionThanks to good tissue distribution and plasma protein binding Vd is 301 l. is low because more than 90% of the absorbed drug is inactivated in the process of one-step metabolism in the liver. Glucocorticoid activity of metabolites does not exceed 1%. ExcretionMetabolites are excreted mainly with urine (70%) and with feces. T1 / 2 is 2-3 hours.
Indications
- prevention and treatment of seasonal and year-round allergic rhinitis; - non-allergic rhinitis; - polyps of the nose.
Contraindications
- fungal, bacterial and viral infections of the respiratory tract; - active form of pulmonary tuberculosis; - Hypersensitivity to budesonide or any other component of the drug.
Precautionary measures
The drug should be stored out of reach of children at a temperature not exceeding 25 ° C.
Use during pregnancy and lactation
The use of the drug Tafen nasal during pregnancy is allowed only if the expected benefit to the mother exceeds the possible risk to the fetus. If you need to take the drug during lactation, breastfeeding should be stopped.
Dosage and administration
Adults and children over the age of 6 at the beginning of therapy are prescribed 2 doses (50 mcg of budesonide) in each nostril 2 times / day. The usual maintenance dose is 1 dose in each nostril 2 times / day or 2 doses in each nostril 1 time / day, in the morning. The maintenance dose should be the lowest effective dose that relieves the symptoms of rhinitis. The maximum single dose is 200 mcg (100 mcg in each nostril), the maximum daily dose is 400 mcg for no more than 3 months. For the full therapeutic effect requires regular and correct application. If a dose is missed, it should be taken as soon as possible, but not less than 1 hour before taking the next regular dose.
Side effects
On the part of the respiratory system: irritation of the mucous membrane of the nose and throat, nosebleeds, cough; rarely observed dry nasal mucosa, sneezing. Dermatological reactions: dermatitis, urticaria, rash. Others: fatigue, dizziness. In exceptional cases, when using nasal corticosteroids, perforation of the nasal septum, angioedema, loss of smell, tachycardia, growth retardation were noted. When using the drug side effects develop very rarely and are transient in nature.
Overdose
Accidental overdose of the drug Tafen nasal does not cause any obvious symptoms. Acute overdose is unlikely. With prolonged use of high doses, as well as while taking other GCS, symptoms of hypercorticism may appear. In this case, the drug should be stopped, gradually reducing its dose.
Interaction with other drugs
The simultaneous use of the drug Tafen Nasal with inducers of microsomal oxidation (phenobarbital, phenytoin, rifampicin) can reduce the effectiveness of the first. Methandrostenolone, estrogens, ketoconazole enhance the effect of budesonide.
special instructions
When switching from treatment with systemic corticosteroids for nasal spray treatment, due to the risk of adrenal insufficiency, caution is required for the period of recovery of the hypothalamic-pituitary-adrenal system function. or nasal surgery. For a full therapeutic effect with allergic rhinitis, you need to take the drug regularly. It is recommended to avoid contact with eyes. e on the ability to drive vehicles and control mechanisms. Tapen nasal does not affect the ability to drive a car or mechanisms.