Tamoxifen pills 20 mg 30 pcs
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Active ingredients
Tamoxifen
Release form
Pills
Composition
Tamoxifen (in the form of citrate) 20 mg
Pharmacological effect
Antitumor agent. Antiestrogen. It blocks estrogen receptors and thus inhibits the progression of estrogen-stimulated neoplastic disease.
Pharmacokinetics
Tamoxifen is metabolized in the liver, undergoes enterohepatic recirculation. Excreted in the bile as metabolites.
Indications
Breast cancer in menopausal women, breast cancer in men after castration, kidney cancer, melanoma (containing estrogen receptors), ovarian cancer; prostate cancer with resistance to other drugs.
Contraindications
Thrombophlebitis, pregnancy, hypersensitivity to tamoxifen.
Use during pregnancy and lactation
Tamoxifen is contraindicated for use in pregnancy. If necessary, use during lactation should stop breastfeeding. In experimental studies found teratogenic effect of tamoxifen.
Dosage and administration
The dosage regimen is set individually, depending on the indications, the patient's condition and the applied anticancer therapy regimen.
Side effects
On the part of the digestive system: nausea, vomiting, increased activity of hepatic transaminases; in some cases - fatty infiltration of the liver, cholestasis, hepatitis.; CNS: rarely - depression, dizziness, headache, retrobulbar neuritis.; From the organ of vision: rarely - retinopathy, keratopathy, cataract; - thrombocytopenia, leukopenia. On the part of the endocrine system: in women - endometrial hyperplasia, vaginal bleeding, hot flashes, weight gain; in men - impotence, decreased libido.; From the side of the cardiovascular system: edema, thromboembolism, phlebitis; Dermatological reactions: alopecia, rash, itching; Other: pain in the bones and lesions, fever.
Overdose
Acute overdose of tamoxifen was not observed in humans. ; Symptoms: It should be expected that an overdose may cause an increase in the above described adverse reactions.; Treatment: there are no specific antidotes; treatment should be symptomatic.
Interaction with other drugs
When applied simultaneously with anticoagulants coumarin derivatives increases the risk of increased anticoagulant action; with cytostatics - possible increase in the risk of thrombosis. With simultaneous use with allopurinol may have a hepatotoxic effect; with aminoglutetimid - reducing the concentration of tamoxifen in plasma, apparently due to an increase in its metabolism.; In patients receiving tamoxifen, prolongation of the neuromuscular blockade caused by atracuria is possible; receiving tamoxifen, with the use of warfarin there is a risk of developing a threatening clinical situation: prolongation of prothrombin time, hematuria, hematoma are possible. th application with mitomycin increased risk of hemolytic-uremic syndrome;. May decrease tamoxifen concentration in blood plasma, which is apparently due to induction of isoenzyme CYP3A4 by rifampicin action;. Estrogens can reduce the therapeutic effect of tamoxifen.
special instructions
With caution used for leukopenia, thrombocytopenia, hypercalcemia, in patients with cataracts, hyperlipidemia. In the course of treatment should regularly monitor the pattern of peripheral blood (especially platelet count); the level of calcium and glucose in the blood; long-term use shows observation of an oculist (every 3 months) .; It should not be combined with drugs containing hormones, especially estrogens.; If used simultaneously with drugs that affect the blood coagulation system, dose adjustment of tamoxifen is necessary. action of tamoxifen.