Tanakan coated pills 40mg N30
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Active ingredients
Ginkgo bilobate leaf extract
Release form
Pills
Composition
1 tablet contains: ginkgo bilobaca leaf extract (EGb 761;) 40 mg, incl. flavonol glycosides 22-26.4%, ginkgolides-bilobalides 5.4-6.6% Excipients: lactose monohydrate - 82.5 mg, microcrystalline cellulose - 50 mg, corn starch - 37 mg, colloidal silicon dioxide - 28 mg, talc - 11.25 mg, magnesium stearate - 1.25 The composition of the shell: hypromellose (E464) - 6 mg, macrogol 400 - 1.5 mg, macrogol 6000 - 1.5 mg, titanium dioxide (E171) - 1 mg, iron red oxide (E172) - 0.7 mg.
Pharmacological effect
An angioprotective agent of plant origin. A standardized and titrated preparation of plant origin, the effect of which is due to the effect on the metabolic processes in the cells, the rheological properties of the blood, and the vasomotor reactions of the blood vessels. The preparation improves the supply of oxygen and glucose to the brain. Normalizes the tone of the arteries and veins, improves microcirculation. It helps to improve blood flow, prevents erythrocyte aggregation. It has an inhibitory effect on platelet activation factor. Improves metabolic processes, has an antihypoxic effect on tissues. Interferes with the formation of free radicals and lipid peroxidation of cell membranes. Affects the release, reuptake and catabolism of neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin) and their ability to bind to membrane receptors.
Pharmacokinetics
Ginkgolides A and B and bilobalides have a bioavailability of 80% to 90% when taken orally. Cmax is reached in 1-2 hours; T1 / 2 ranges from 4 hours (ginkgolide A and bilobalide) to 10 hours (ginkgolide B). The main route of elimination is the kidneys.
Indications
Cognitive and neurosensory deficits of various genesis (with the exception of Alzheimer's disease and dementia of various etiologies). Intermittent claudication in chronic obliterating arteriopathies of the lower extremities (II degree in Fontein). Disorders of vascular genesis, reduction in its acuity. coordination disorders mainly Vascular genesis. Illness and Raynaud's syndrome.
Contraindications
Hypersensitivity to any of the components of the drug.Pregnancy and lactation period (breastfeeding).
Precautionary measures
C caution should be prescribed to patients with alcoholism, liver diseases, head injuries and brain diseases, since the drug in the form of a solution contains 450 mg of ethyl alcohol per dose (1 dose).
Use during pregnancy and lactation
The use of the drug Tanakan is contraindicated during pregnancy and lactation (breastfeeding) due to the lack of clinical data on the use of the drug in this group of patients.
Dosage and administration
Assign 40 mg (1 tablet or 1 ml of oral solution) 3 times / day with meals. Accept Inside. The tablet should be taken with half a glass of water.
Side effects
From the side of the central nervous system headache, dizziness, insomnia. From the digestive system dyspepsia. Allergic reactions skin rash.
Overdose
Currently, overdose cases are not registered.
Interaction with other drugs
In clinical studies with EGb 761, both inhibition and induction of cytochrome P450 isoenzymes were detected. With co-administration of EGb 761 with midazolam, the level of the latter changed presumably due to exposure to CYP3A4. Thus, care must be taken when sharing EGb 761 and drugs metabolized by the CYP3A4 isoenzyme and having a low therapeutic index. Patients who regularly receive acetylsalicylic acid (as an antiplatelet agent), anticoagulants (direct and indirect action) and other drugs that lower blood coagulability. With simultaneous use of Tanakan in the form of an oral solution with antibiotics of the cephalosporins group (cefamandol, cefopera Azone, Latonexia, Gentamicin ornidazole, secnidazole, tinidazole), ketoconazole, cytostatics (procarbazine), tricyclic antidepressants, tranquilizers, such reactions as hyperthermia may occur, hyperemia of the skin, vomiting, palpitations, since 1 dose of Tanakan in the form of oral solution contains 450 mg of ethyl alcohol.
special instructions
Before using the drug, consultation with a doctor is necessary. Improvement of the condition is manifested 1 month after the start of treatment. One single dose of the oral solution contains 450 mg of ethyl alcohol (57% v / v), the maximum daily dose is 1.35 g of ethyl alcohol. Effect on ability to drive motor vehicles and control mechanisms. During the period of taking the drug, it is not recommended to perform potentially hazardous activities that require high concentration of attention and psychomotor speed of reactions (including REMEDIES work with moving mechanisms), since the the drug may cause dizziness and the solution contains ethyl alcohol.