Teveten plus coated pills 600mg N28
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Active ingredients
Hydrochlorothiazide + Eprosartan
Release form
Pills
Composition
Eprosartan mesilate 735.8 mg, which corresponds to the content of eprosartan 600 mg hydrochlorothiazide 12.5 mg. Auxiliary substances: microcrystalline cellulose - 43.3 mg, lactose monohydrate - 43.3 mg, 43.3 mg pregelatinized starch - 43.3 mg, crospovidone - 38.5 mg, 93% mg, 93% mg, 93% mg; .The composition of the film shell: Opadry II Butterscotch 85F27320 - 39 mg (polyvinyl alcohol - 15.6 mg, macrogol 3350 - 7.88 mg, talc - 5.77 mg, titanium dioxide (E171) - 9.41 mg, ferric oxide yellow (E172) - 0.33 mg, iron black oxide (E172) - 0.004 mg).
Pharmacological effect
Tevet Plus has a hypotensive, vasodilating, diuretic effect.
Indications
Arterial hypertension.
Contraindications
Hypersensitivity to Tevetin Plus components; pregnancy; breastfeeding period; age under 18 years old (efficacy and safety not established). With caution: severe heart failure III – IV FC (NYHA); bilateral renal artery stenosis, renal artery stenosis of the only kidney ; reduced bcc as a result of vomiting, diarrhea, receiving high doses of diuretics. The company has no safety data on Teveten in patients with end-stage renal disease (Cl creatinine less than 5 ml / min, uremia II), and also ientov on hemodialysis.
Precautionary measures
During treatment, psoriasis may worsen. During pheochromocytoma, propranolol can only be used after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. during anesthesia, you must stop taking propranolol or find a remedy for anesthesia with minimal negative inotropic effects. The impact on the ability to drive vehicles and control mechanisms of patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient.
Dosage and administration
Tevet Plus is taken orally, in 1 tab. per day, in the morning, regardless of the meal. Selection of the dose of Tevetin Plus in elderly patients, patients with mild and moderate liver dysfunction, as well as patients with impaired renal function (Cl creatinine more than 30 ml / min) is not required.
Side effects
The overall incidence of side effects reported in patients taking eprosartan is comparable to that taken with placebo. These actions, as a rule, were mild and short-lived, so that cessation of treatment was required only in 4.1% of patients who took eprosartan during placebo-controlled clinical trials (6.5% in the placebo group). rarely - headache, dizziness, asthenia. From the cardiovascular system: very rarely - decrease in blood pressure, incl. postural hypotension. From the side of the skin and subcutaneous fatty tissue: rarely - skin reactions (rash, itching and urticaria); very rarely - swelling of the face, angioedema. Other: rarely - cough.
Interaction with other drugs
The antihypertensive effect may increase with simultaneous use with other antihypertensive agents. When used in conjunction with oral hypoglycemic agents, it is necessary to adjust their dose, since hydrochlorothiazide may decrease glucose tolerance. When used simultaneously with lithium preparations, a reversible increase in plasma lithium concentration and an increased risk of its toxic effects may occur (careful monitoring of lithium concentration in patients receiving this combination is necessary). Plus. By lowering potassium, hydrochlorothiazide can increase the effects of cardiac glycosides and some antiarrhythmic drugs. Hydrochlorothia Azide increases the risk of hypokalemia when it is prescribed, along with drugs that cause the body to lose potassium, for example, diuretics that have a potassium uretic effect, laxatives, GCS and ACTH. Hydrochlorothiazide absorption is reduced when anion exchange resins are taken together (for example, colestiramine or colestipol).
special instructions
Based on the pharmacodynamic properties, Teveten Plus should not affect the ability to drive and use of machines and mechanisms. During the treatment of hypertension, care must be taken when driving motor vehicles and engaging in potentially hazardous activities that require increased concentration and psychomotor speed, due to the fact that dizziness and weakness may occur.