Tiloram coated pills 125mg N6
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Active ingredients
Tiloron
Release form
Pills
Composition
Tilorone (in the form of dihydrochloride) 125 mg; Excipients: lactose monohydrate (milk sugar) - 101 mg, microcrystalline cellulose - 45 mg, croscarmellose sodium - 9 mg, water - 5 mg, povidone K17 - 12 mg, magnesium stearate - 3 mg . The composition of the shell: hypromellose - 5.7 mg, macrogol 4000 - 1.4 mg, titanium dioxide - 2.8 mg, dye tropeolin O - 0.1 mg.
Pharmacological effect
Low molecular weight synthetic inducer of interferon, which stimulates the formation in the body of interferons alpha, beta and gamma. The main producers of interferon in response to the introduction of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After ingestion, the maximum production of interferon is determined in the sequence intestine - liver - blood in 4-24 hours. Tilorone has an immunomodulatory and antiviral effect. In human leukocytes induces the synthesis of interferon. Stimulates bone marrow stem cells, enhances antibody production, depending on the dose, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helper cells. Effective against various viral infections, including influenza viruses and other acute respiratory viral infections, hepatitis viruses and herpes viruses. The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which reproduction of viruses is inhibited.
Indications
Treatment and prevention of influenza and other acute respiratory viral infections (ARVI); treatment of viral hepatitis A, B and C; treatment of herpes and cytomegalovirus infection; as part of the complex treatment of infectious-allergic and viral encephalomyelitis (multiple sclerosis, leukoencephalitis, uveoencephalitis, etc.); in the complex therapy of urogenital and respiratory chlamydia; in the treatment of pulmonary tuberculosis.
Contraindications
• hypersensitivity to tilorone and other components of the drug; • pregnancy and lactation period; • children's age up to 18 years; • hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption
Use during pregnancy and lactation
Tiloron is contraindicated for use during pregnancy and lactation (breastfeeding).
Dosage and administration
Tiloron is taken orally after meals. ; For the treatment of viral hepatitis A - on the first day, 125 mg 2 times, then 125 mg every 48h. On the course - 1.25g. For the treatment of acute hepatitis B, the first two days take 125 mg, then 125 mg after 48 hours, for a course of treatment - 2 g. With a protracted course of hepatitis B, 125 mg 2 times a day on the first day, then 125 mg every 48 hours. In the course of treatment - 2.5 g. In chronic hepatitis B - the initial phase of treatment (2.5 g) - the first two days, 125 mg 2 times a day, then 125 mg after 48 hours. The continuation phase (from 1.25 g to 2.5 g), 125 mg per week. Course dose tilorone from 3.75 g to 5 g, the duration of therapy is 3.5-6 months, depending on the results of biochemical, immunological, morphological studies, reflecting the degree of activity of the process.
Side effects
Possible: short-term chills, allergic reactions.; In some cases: dyspeptic symptoms.
Interaction with other drugs
Tiloron is compatible with antibiotics, traditional means of treating viral and bacterial diseases.
special instructions
It is not recommended to use tilaran in doses higher than recommended, in order to avoid possible short-term depletion of immunocompetent cells. As part of complex therapy of neurovirus infections, tilorone is used under the supervision of a doctor.