Troxevasin capsules 300 mg 100 pcs
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Active ingredients
Troxerutin
Release form
Capsules
Composition
1 tablet contains: Troxerutin 300 mg. Excipients: lactose monohydrate - 47 mg, magnesium stearate - 3 mg. Shell composition: quinoline yellow dye (E104) - 0.9%, sunset sunflower yellow (E110) - 0.039%, titanium dioxide (E171) - 3%, gelatin - up to 100%.
Pharmacological effect
Angioprotective drug, acts primarily on the capillaries and veins. Reduces the pores between endothelial cells by modifying the fibrous matrix located between the cells of the endothelium. Inhibits aggregation and increases the degree of deformability of red blood cells; has anti-inflammatory effect. In chronic venous insufficiency, Troxevasin; reduces the severity of swelling, pain, cramps, trophic disorders, varicose ulcers. Relieves the symptoms associated with hemorrhoids - pain, itching and bleeding. Thanks to the beneficial effects on the permeability and resistance of the capillary walls, Troxevasin; helps to slow down the development of diabetic retinopathy. In addition, its effect on the rheological properties of blood contributes to the prevention of microthrombosis of retinal vessels.
Pharmacokinetics
Absorption After oral absorption is about 10-15%. Cmax in plasma is reached on average 2 hours after administration, the therapeutic plasma level is maintained for 8 hours. Metabolism and excretion Metabolized in the liver. Partially excreted unchanged in the urine (20-22%) and with bile (60-70%).
Indications
Chronic venous insufficiency; post-phlebitic syndrome; trophic disorders in varicose disease; trophic ulcers; as an adjunctive treatment after vein sclerotherapy and varicose node removal; hemorrhoids (pain, exudation, itching, bleeding); venous insufficiency and hemorrhoids during pregnancy, starting from the second trimester; as an auxiliary treatment of retinopathy in patients with diabetes mellitus, with arterial hypertension and atherosclerosis.
Contraindications
Peptic ulcer and duodenal ulcer in the acute phase; chronic gastritis in the acute phase; I trimester of pregnancy; hypersensitivity to the drug; hypersensitivity to rutozidam.
Precautionary measures
In diabetic retinopathy prescribed in a dose of 0.9-1.8 g / day. With caution should use the drug for a long time in renal failure, as well as in children aged 3 to 15 years.
Use during pregnancy and lactation
Use of the drug Troxevasin; in the first trimester of pregnancy is contraindicated. In the second and third trimesters and during lactation (breastfeeding) the use of the drug is possible when the expected benefit of therapy for the mother outweighs the potential risk to the fetus or infant.
Dosage and administration
The drug is taken orally during meals. Capsules should be swallowed whole with a large amount of water. At the beginning of treatment, 300 mg (1 capsule) is prescribed 3 times / day. The effect usually develops within 2 weeks, after which the treatment is continued at the same dose or reduced to the minimum maintenance level of 600 mg, or suspended (at the same time, the achieved effect lasts for at least 4 weeks). The course of treatment is on average 3-4 weeks, the need for longer treatment is determined individually.
Side effects
On the part of the digestive system: nausea, diarrhea, heartburn, erosive and ulcerative lesions of the gastrointestinal tract. Others: skin rash, headache, flushing to the face. Side effects quickly disappear after stopping treatment.
Overdose
Symptoms: agitation, nausea, headache, hot flashes to the face. Treatment: gastric lavage, taking activated charcoal, if necessary - conducting symptomatic therapy.
Interaction with other drugs
The effect of the drug is enhanced while taking ascorbic acid.
special instructions
If during the period of use of the drug, the severity of symptoms of the disease does not decrease, you should consult with your doctor. Use in pediatrics Experience with the use of the drug Troxevasin; in children under the age of 15 years is not enough, which requires caution when applying it. Effects on the ability to drive vehicles and control mechanisms Reception of the drug does not affect the motor and mental reactions, does not interfere with the management of vehicles and work with mechanisms.