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Active ingredients
Tiaprid
Release form
Pills
Composition
Active ingredient: Tiapride; Concentration of active ingredient (mg): 100 mg
Pharmacological effect
Antipsychotic agent (neuroleptic) from the group of substituted benzamides. The antipsychotic effect is due to the blockade of the dopamine D2 receptors of the mesolimbic or mesocortical system. It has an analgesic effect in interoceptive and exteroceptive pain. It has a sedative effect due to blockade of adrenoreceptors of the reticular formation of the brain stem; antiemetic effect associated with blockade of dopamine D2 receptors in the trigger zone of the vomiting center; hypothermic effect due to blockade of the dopamine receptors of the hypothalamus.
Pharmacokinetics
After ingestion is rapidly absorbed from the gastrointestinal tract. Cmax in plasma is achieved after 1 h. Plasma protein binding is low. Penetrates the BBB. T1 / 2 is 3-4 hours. The kidneys are mainly excreted unchanged .; In renal failure, the elimination of Tiapride from the body is slowed down.
Indications
Tiapride is intended for the treatment of adults with chronic pain, patients in a state of psychomotor agitation, aggression in old age or during alcoholism. It is recommended that children and adults take medication pills with chorea and Gilles de la Tourette syndrome. The drug is effective in the treatment of children over 6 years of age with behavioral disorders accompanied by agitation and aggression. ; Tiapride injections are successfully used for the treatment of chorea, tremor, nervous tic, hyperkinetic and dyskinetic syndromes, psychomotor agitation, parkinsonism of vascular origin, neurogenic headache cause. The drug assists patients with alcohol and substance abuse in behavioral disturbances in abstinence and alcohol psychosis. Tiapride is effective in senile motor instability, various behavioral disorders of the elderly and chronic pain syndrome.
Contraindications
It is forbidden to use Tiapride for people with allergies to the composition of the drug.It is not recommended to use the drug for pheochromocytoma, hypertensive crisis, kidney failure. ; Tiapride pills are contraindicated in children under 6 years of age, and in the form of injections - up to 7 years. ; Tablets are prohibited to use in patients with prolactin-dependent tumors. ; The drug should be used with caution in patients with chronic kidney failure, epilepsy, Parkinson's disease, heart disease and vascular disease during decompensation. With caution Tiapride used for the elderly. ; Tiapride pills with increased attention should be used in patients with bradycardia, hypokalemia, increased QT interval. ;
Use during pregnancy and lactation
In pregnancy, Tiapride is used only by absolute indications in the minimum effective doses. Newborns whose mothers received Tiapride during pregnancy are advised to monitor the functions of the central nervous system and gastrointestinal tract .; It is not known whether Tiapride is excreted in breast milk. If necessary, use during lactation breastfeeding should be discontinued.
Dosage and administration
Tiapride pills; It is recommended to start treatment of aggression and psychomotor agitation with Tiapride pills with minimum doses, gradually increasing to 200–300 mg / day. The dose is increased by 0.05-0.1 g at 2–3-day intervals. The daily maximum is 300 mg. The course of treatment should be at least 1-2 months. ; Chronic pain syndrome is treated with a dosage of Tiapride 0.2-0.4 g / day. ; The drug in pills for chorea, de la Tourette syndrome should be consumed at 0.3–0.8 g / day. Reception begins with 20 mg per day and gradually increased to the recommended. Children the dosage of the drug should be selected individually, at the rate of 3–6 mg / kg / day. ; In the treatment of children with behavioral disorders and agitation, Tiapride should be consumed at 100–150 mg / day. ; Solution for the / m and / in the introduction; With constant pain Tiapride syndrome is used at 200-400 mg / day. ; The delirious state is treated with injections of the drug with an interval of 4-6 hours, bringing the dose to 0.4-1.2 g / day. The total dose of the drug should not exceed 1800 mg. ; In childhood, the solution for injection should be used at 100-150 mg / day. Daily maximum should not exceed 300 mg.
Side effects
Treatment with Tiapridom is often accompanied by drowsiness, increased fatigue, dizziness, increased pressure, insomnia, asthenia, apathy, agitation, Parkinson's syndrome (heart rate slowing, increased salivation, tremor). Less commonly, medication treatment causes reversible dystonia symptoms, early dyskinesias, and astasia. Prolonged use of the drug may cause tardive dyskinesia. Rarely, treatment with pills Tiapride causes hyperprolactinemia and related disorders: galactorrhea, amenorrhea, impotence, breast enlargement, weight gain, atrial fibrillation, chest pain, neuroleptic malignant syndrome, impaired ejaculation, postural hypotension, gynecomastia and frigid. ; Tiapride parenteral administration can cause muscle weakness, allergies, hyperthermia, agitation and orthostatic hypotension. Medication injections are less likely to cause extrapyramidal symptoms and overstimulation (anxiety, exacerbation of schizophrenia symptoms).
Overdose
Currently, no cases of overdose have been reported.
Interaction with other drugs
With the simultaneous use of depressants of the central nervous system (including opioid analgesics, antihistamines, barbiturates, benzodiazepines), it is possible to increase the inhibitory effect on the central nervous system .; With the simultaneous use of antihypertensive drugs may increase the hypotensive effect.
special instructions
With extreme caution used in patients with epilepsy due to the possible lowering of the threshold of convulsive readiness .; To use with caution in severe cardiovascular diseases, parkinsonism, renal failure, as well as in elderly patients .; Parenteral administration is carried out under the supervision of a physician .; During treatment with tiapridom, do not use levodopa, dopamine receptor agonists (amantadine, apomorphine, bromocriptine, cabergoline, entacapone, lizurid, pergolid, piribedil, pramipexole, hinagolid), sultopride; drugs that can cause arrhythmias of the "pirouette" type (class I A and III antiarrhythmic drugs, chlorpromazine, levomepromazine, thioridazine, trifluoperazine, sultopride, droperidol, haloperidol, pimozide, bepridil, cisapride, diphemanil,erythromycin for iv administration, vincamine for iv administration, as well as halofantrine, morfloxacin, pentamidine, sparfloxacin) .; Avoid alcohol consumption .; Influence on ability to drive motor transport and control mechanisms; They are used with caution in patients whose activity requires concentration of attention and high speed of psychomotor reactions.