Venlafaxine pills 37.5mg N30
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Active ingredients
Venlafaxine
Release form
Pills
Composition
1 tab. venlafaxine (in the form of hydrochloride) 37.5 mg. Excipients: microcrystalline cellulose 67.
Pharmacological effect
Venlafaxine - an antidepressant chemically not related to any class of antidepressants (tricyclic, tetracyclic, or others), is the racemate of two active enantiomers. Venlafaxine and its main metabolite, O-desmethylvenlafaxine (EFA), are potent inhibitors of serotonin reuptake and noradrenaline (abbreviated: IOSPN or SSRI) and weak inhibitors of dopamine reuptake. The mechanism of antidepressant action is associated with the ability of the drug to enhance the activity of neurotransmitters during the transmission of nerve impulses in the central nervous system (CNS). Venlafaxine and EFA equally effectively affect the reuptake of the above-mentioned neurotransmitters, while they do not have affinity (studied in vitro) with cholinergic (muscarinic), histamine (H1), alpha1-adrenergic, opioid, and benzodiazepine receptors, in response to inaccuracy patterns, inaccurate, inaccurate, inoperative, non-active, inaccurate, inoperative, non-active, non-transferential neurotransmitters. . By inhibition of serotonin reuptake, venlafaxine is inferior to selective serotonin reuptake inhibitors (SSRIs).
Indications
- depression: prevention and treatment.
Contraindications
- hypersensitivity to venlafaxine or to any of the excipients - simultaneous use with MAO inhibitors - severe impaired renal function (glomerular filtration rate (GFR) less than 10 ml / min) - severe impaired liver function - taking the drug under the age of 18 - during pregnancy and during lactation. Precautions: recent myocardial infarction, unstable angina pectoris, hypertension, arrhythmia (especially tachycardia), convulsions history, increased intraocular pressure, angle-closure glaucoma, manic state history, suicidal tendencies, predisposition to bleeding from the skin and mucous membranes , initially reduced body weight, hyponatremia, dehydration, concurrently with diuretics, or with drugs used to treat obesity.
Use during pregnancy and lactation
Do not assign venlafaxine to pregnant and lactating women, because the safety of the drug during pregnancy and lactation in a woman has not been established to a sufficient extent, due to the fact that there are no adequately conducted controlled clinical studies on a sufficiently large sample of such patients. This concerns the health of both the mother and, to a greater extent, the fetus / child. Women of childbearing age should be warned about this before starting treatment; they should immediately consult a doctor if they become pregnant or are planning a pregnancy during the period of drug treatment. Venlafaxine and its metabolite (EFA) are excreted in breast milk. If necessary, taking the drug during lactation is necessary to stop breastfeeding. In practice, there are cases of prescribing venlafaxine to mothers during pregnancy and shortly before delivery, when in a particular situation the expected benefits to the mother outweigh the potential risk to the fetus. In these cases, newborns often observed complications that required: an increase in the length of hospitalization, maintenance of breathing and feeding through a tube. These complications can develop immediately after childbirth and are also characteristic in the case of taking other antidepressants from the group of SSRIs or SSRIs (not containing venlafaxine). In such cases, the following clinical symptoms in newborns were reported: respiratory disorders, cyanosis, apnea, convulsions, temperature instability, feeding difficulties, vomiting, hypoglycemia, muscle hypertension or hypotension, hyperreflexia, tremor, tremors, irritability, lethargy, constant crying, sleepiness or insomnia. Such violations may indicate the serotonergic effects of the drug Venlafaxine. If venlafaxine was used during pregnancy, and treatment of the mother was completed shortly before birth, the newborn may experience withdrawal syndrome. In such a newborn, the presence of serotonin syndrome or a neuroleptic malignant syndrome should be excluded. Epidemiological data suggest that using SSRIs during pregnancy, especially in late pregnancy, may increase the risk of persistent pulmonary hypertension in the newborn.
Side effects
Frequency of side effects: very often (& # 8805 .1 / 10), often (& # 8805 .1 / 100 to less than 1/10), infrequently (& # 8805 .1 / 1000 to less than 1/100), rarely ( & # 8805 .1 / 10 000 to less than 1/1000), very rarely (less than 1/10 000), the frequency has not been established (currently there are no data on the prevalence of adverse reactions). Common symptoms: often - weakness, fatigue, chills. Infrequently - angioedema, photosensitivity reactions. frequency not established - anaphylactic reactions. On the part of the nervous system: very often - dry mouth, headache. often - unusual dreams, decreased libido, dizziness, insomnia, irritability, paresthesia, stupor, confusion, depersonalization, increased muscle tone, tremor. infrequently - apathy, agitation, hallucinations, myoclonus, impaired coordination and balance. rarely - akathisia, psychomotor agitation, epileptic seizures, manic reactions. frequency not established - dizziness, malignant neuroleptic syndrome (ZNS), serotonin syndrome, delusions, extrapyramidal reactions (including dystonias and dyskinesia), tardive dyskinesia, suicidal thoughts and behavior, aggression. On the part of the gastrointestinal tract: very often - nausea. often - loss of appetite (anorexia), constipation, vomiting. infrequently - bruxism, diarrhea. rarely - hepatitis. frequency is not installed - pancreatitis. On the part of the respiratory system: often - yawning, bronchitis, shortness of breath. rarely, interstitial lung disease and eosinophilic pneumonia, chest pain. Since the cardiovascular system: often - arterial hypertension, hyperemia of the skin. infrequently - postural hypotension, tachycardia, syncope. frequency not established - hypotension, prolongation of the QT interval, ventricular fibrillation, ventricular tachycardia (including bidirectional tachycardia). From the hematopoietic system: infrequently - hemorrhages into the skin (ecchymosis), gastrointestinal bleeding. frequency not established - hemorrhages in mucous membranes, lengthening of bleeding time, thrombocytopenia, pathological changes in the blood (including agranulocytosis, aplastic anemia, neutropenia and pancytopenia). On the part of the metabolism: often - an increase in the level of cholesterol in the blood serum, a decrease in body weight. Infrequently - weight gain. very rarely - an increase in prolactin content. frequency not established - change in laboratory tests of liver function, hepatitis, hyponatremia, syndrome of insufficient secretion of antidiuretic hormone.On the part of the urogenital system: often - ejaculation / orgasm disorders (in men), erectile dysfunction (impotence), anorgasmia, dysuric disorders (mainly - difficulty starting urination), pollakiuria, menstrual disorders associated with increased bleeding or increased irregular bleeding ( menorrhagia, metrorrhagia). infrequently - violations of orgasm (in women), urinary retention. rarely urinary incontinence. From the sense organs: often - accommodation disturbances, mydriasis, visual disturbances. infrequently - a violation of taste, noise or tinnitus. frequency not set - angle-closure glaucoma. For the skin: very often - sweating. infrequently - alopecia, fast passing rash. frequency not established - erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, pruritus, urticaria. On the part of the musculoskeletal system: the frequency is not installed - rhabdomyolysis. When you stop taking venlafaxine, abruptly cancel or while reducing the dose, you may experience symptoms related to the so-called withdrawal syndrome: fatigue, asthenia, headache, dizziness, sleep disorders (drowsiness or insomnia, difficulty falling asleep, the appearance of unusual dreams), hypomania, anxiety, agitation (increased nervous excitability and irritability), confusion, paresthesia (spontaneously unpleasant feeling of numbness, tingling, burning, goosebumps, etc.), rapid sweating, dry mouth, decreased appetite, nausea, vomiting, diarrhea (most of these reactions are mild and do not require treatment).
special instructions
Frequency of side effects: very often (& # 8805 .1 / 10), often (& # 8805 .1 / 100 to less than 1/10), infrequently (& # 8805 .1 / 1000 to less than 1/100), rarely ( & # 8805 .1 / 10 000 to less than 1/1000), very rarely (less than 1/10 000), the frequency has not been established (currently there are no data on the prevalence of adverse reactions). Common symptoms: often - weakness, fatigue, chills. Infrequently - angioedema, photosensitivity reactions. frequency not established - anaphylactic reactions. On the part of the nervous system: very often - dry mouth, headache. often - unusual dreams, decreased libido, dizziness, insomnia, irritability, paresthesias, stupor,confusion, depersonalization, increased muscle tone, tremor. infrequently - apathy, agitation, hallucinations, myoclonus, impaired coordination and balance. rarely - akathisia, psychomotor agitation, epileptic seizures, manic reactions. frequency not established - dizziness, malignant neuroleptic syndrome (ZNS), serotonin syndrome, delusions, extrapyramidal reactions (including dystonias and dyskinesia), tardive dyskinesia, suicidal thoughts and behavior, aggression. On the part of the gastrointestinal tract: very often - nausea. often - loss of appetite (anorexia), constipation, vomiting. infrequently - bruxism, diarrhea. rarely - hepatitis. frequency is not installed - pancreatitis. On the part of the respiratory system: often - yawning, bronchitis, shortness of breath. rarely, interstitial lung disease and eosinophilic pneumonia, chest pain. Since the cardiovascular system: often - arterial hypertension, hyperemia of the skin. infrequently - postural hypotension, tachycardia, syncope. frequency not established - hypotension, prolongation of the QT interval, ventricular fibrillation, ventricular tachycardia (including bidirectional tachycardia). From the hematopoietic system: infrequently - hemorrhages into the skin (ecchymosis), gastrointestinal bleeding. frequency not established - hemorrhages in mucous membranes, lengthening of bleeding time, thrombocytopenia, pathological changes in the blood (including agranulocytosis, aplastic anemia, neutropenia and pancytopenia). On the part of the metabolism: often - an increase in the level of cholesterol in the blood serum, a decrease in body weight. Infrequently - weight gain. very rarely - an increase in prolactin content. frequency not established - change in laboratory tests of liver function, hepatitis, hyponatremia, syndrome of insufficient secretion of antidiuretic hormone. On the part of the urogenital system: often - ejaculation / orgasm disorders (in men), erectile dysfunction (impotence), anorgasmia, dysuric disorders (mainly - difficulty starting urination), pollakiuria, menstrual disorders associated with increased bleeding or increased irregular bleeding ( menorrhagia, metrorrhagia). infrequently - violations of orgasm (in women), urinary retention. rarely urinary incontinence.From the sense organs: often - accommodation disturbances, mydriasis, visual disturbances. infrequently - a violation of taste, noise or tinnitus. frequency not set - angle-closure glaucoma. For the skin: very often - sweating. infrequently - alopecia, fast passing rash. frequency not established - erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, pruritus, urticaria. On the part of the musculoskeletal system: the frequency is not installed - rhabdomyolysis. When you stop taking venlafaxine, abruptly cancel or while reducing the dose, you may experience symptoms related to the so-called withdrawal syndrome: fatigue, asthenia, headache, dizziness, sleep disorders (drowsiness or insomnia, difficulty falling asleep, the appearance of unusual dreams), hypomania, anxiety, agitation (increased nervous excitability and irritability), confusion, paresthesia (spontaneously unpleasant feeling of numbness, tingling, burning, goosebumps, etc.), rapid sweating, dry mouth, decreased appetite, nausea, vomiting, diarrhea (most of these reactions are mild and do not require treatment).