Vizin allergy eye drops 0.05% 4ml
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Active ingredients
Levocabastine
Release form
Drops
Composition
In 1 ml. suspension: levocabastine hydrochloride 540 g, which corresponds to content 500 levocabastine mkg.Vspomogatelnye ingredients: propylene glycol - 48.26 L, sodium phosphate - 8.66 mg sodium dihydrogen phosphate monohydrate - 5.38 mg hypromellose (2910 mPa.s 3) - 2.5 mg polysorbate 80 - 1 mg, benzalkonium chloride - 150 μg (in the form of a 50% solution - 30 μl), disodium edetate - 150 μg, water for injection - up to 1 ml.
Pharmacological effect
Antiallergic drug, a selective blocker of histamine H1-receptors long-lasting. Local effect occurs within 5 minutes. Vizin; Alerdzhi eliminates the typical symptoms of allergic conjunctivitis (itching, redness, swelling of the conjunctiva and eyelids, lacrimation). The effect lasts up to 12 hours.
Pharmacokinetics
Absorption and distribution: After instillation into the eyes at a dose of 15 mcg / drop, about 6 mcg of levocabastin is absorbed. Cmax in plasma is reached after approximately 6 hours. The binding of levocabastine to plasma proteins is approximately 55%. Metabolism and excretion: The main metabolite of levocabastine, acylglucuronide, is formed during glucuronidation, which is the main pathway for the formation of metabolites. T1 / 2 of levocabastine is 39-70 h. Levocabastin is excreted mainly by the kidneys in unchanged form (about 70% of the absorbed amount).
Indications
Allergic conjunctivitis.
Contraindications
Wearing contact lenses; - children up to 12 years; - lactation period (breastfeeding); - hypersensitivity to the drug.
Precautionary measures
With care: patients of advanced age, a renal failure.
Use during pregnancy and lactation
There are no data on the use of levocabastin in pregnant women. Therefore, it is not recommended to use Vizin eye drops; Alergi during pregnancy, except when the expected benefit of therapy for the mother outweighs the potential risk to the fetus. Levocabastin is excreted in breast milk, so if you need to use the drug during lactation, breastfeeding should be discontinued. In preclinical studies on animals, levocabastin when administered systemically in doses up to 2500 times (in terms of mg / kg) higher than the recommended maximum dose for topical use in humans did not cause embryotoxic and teratogenic effects.In animals with systemic administration of levocabastin in doses more than 5,000 times (in terms of mg / kg) exceeding the recommended maximum dose for topical use in humans, teratogenic properties and / or an increase in the death of embryos are noted.
Dosage and administration
Apply locally. For adults and children over 12 years: 1 drop in each eye 2 times / day, if necessary - 3-4 times / day. Treatment should continue until symptoms disappear. Because Vizin eye drops; Alergi are a suspension, before each use the bottle must be shaken. Using a dropper bottle. Remove the cap from the dropper bottle and turn the bottle upside down. Do not touch the tip of the bottle on any surfaces. After use, screw the cap on the dropper bottle.
Side effects
Adverse events that have been noted during clinical studies. On the part of the organ of vision: eye irritation. Postmarketing data: Determination of the frequency of adverse events: very often (more than 1/10), often (more than 1/100, less than 1/10), infrequently (more than 1/1000, less / 100), rarely (more than 1/10 000, less than 1/1000), very rarely (less than 1/10 000, including individual cases). On the part of the organ of vision: often - pain in the eye area, blurred vision; infrequently - eyelid edema; frequency is unknown - conjunctivitis, blepharitis, eye hyperemia, burning sensation, itching, tearing. Systemic reactions: frequency unknown - angioedema, allergic reactions, contact dermatitis, urticaria; often - a headache.
Overdose
Symptoms: in case of accidental ingestion, a decrease in blood pressure, tachycardia, marked sedation is possible. Treatment: forced diuresis.
special instructions
During treatment, it is not recommended to use soft (hydrophilic) contact lenses - possible interaction with the benzalkonium chloride contained in the preparation. To prevent microbial contamination, avoid touching the eyelids with a pipette and close the vial tightly. The patient should be informed that the expiration date has expired or should not be disposed of in sewage or on the street. It is necessary to put the drug in the bag and put it in the trash. These measures will help protect the environment. Impact on the ability to drive vehicles and control mechanisms: Vizin eye drops; Alerji do not affect the speed of psychomotor reactions. The drug can be used by patients who are engaged in driving a car or working with equipment.