Analgin-ultra pills coated 500mg N10 obl
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Active ingredients
Metamizole Sodium
Release form
Pills
Composition
Metamizole Sodium 500 mg
Pharmacological effect
Metamizole sodium - the active ingredient Analgin - has analgesic, antipyretic and weak anti-inflammatory effects. neutrophilic leukocytes, etc. It is a derivative of pyrazolone. The action develops in 20–40 minutes and reaches a maximum after 2 hours.
Pharmacokinetics
After ingestion, metamizole sodium is rapidly hydrolyzed in the gastric juice to form an active metabolite of 4-methyl-amino-antipyrine, which after absorption is metabolized to 4-formyl-amino-antipyrine and other metabolites. After iv administration, metamizole sodium quickly becomes unavailable for determination. Metamolites of metamizole sodium do not bind to plasma proteins. The largest part of the dose is excreted in the urine in the form of metabolites. Metabolites are excreted in breast milk.
Indications
Pain syndrome of various genesis (renal and biliary colic, neuralgia, myalgia; with injuries, burns, after operations; headache, toothache, menalgia). Fever with infectious and inflammatory diseases.
Contraindications
Hypersensitivity to pyrazolone derivatives (butadion, tribuzone), susceptibility to bronchospasm. Severe disorders of the liver or kidneys, deficiency of glucose-6-phosphate dehydrogenase, blood diseases.
Use during pregnancy and lactation
Analgin-ultra is used with caution during pregnancy, especially in the first trimester and in the last 6 weeks.
Dosage and administration
Inside adults appoint 0.25-0.5 g 2-3 times a day after meals. The maximum single dose - 1 g, daily - 3 g. Children should be prescribed 5-10 mg / kg of weight 3-4 times a day. Single doses for oral administration for children aged: 2-3 years - 0.05-0.1 g; 4-5 years - 0.1-0.2 g; 6-7 years - 0.2 g; 8- 14 years old - 0.25-0.3 g. Destination rate - 2-3 times a day.
Side effects
Allergic reactions: skin rash, angioedema; rarely - anaphylactic shock. From the hematopoietic system: rarely, with prolonged use - leukopenia, agranulocytosis.
Overdose
Currently no data available.
Interaction with other drugs
With simultaneous use with antipyretic analgesics, with NSAIDs, mutual toxic effects are possible. Simultaneous use of microsomal liver enzymes with inducers may reduce the effectiveness of metamizole sodium. Simultaneous use increases the activity of indirect anticoagulants, oral hypoglycemic drugs, GCS, indomethacin due to their replacement from the bond with blood proteins under the influence of metamizole sodium. When used concurrently with phenothiazine derivatives, zhennaya hyperthermia; with sedatives, anxiolytics - the analgesic effect of metamizole sodium is enhanced; with tricyclic antidepressants, oral contraceptives, allopurinol - Metamizole sodium metabolism is disturbed and its toxicity increases; with caffeine - the effect of metamizole sodium is enhanced; with cyclosporine - decreases the concentration of cyclosporine in the blood plasma. When using metamizole sodium in combination with pitofenone hydrochloride (has a direct myotropic effect on the smooth muscles of the internal organs and causes its relaxation) and with fenpiverinium bromide (m-holinoblokator), their pharmacological action is reinforced, which is accompanied by a decrease in pain, relaxation of smooth muscles and a decrease in elevated body temperature.
special instructions
When treating children under 5 years old and patients receiving cytostatic drugs, Metamizole sodium should be taken only under medical supervision. Intolerance is very rare, but the risk of anaphylactic shock after IV administration is relatively higher than after taking the drug inside. Atopic bronchial asthma and pollinosis have an increased risk of developing allergic reactions. Agranulocytosis may develop against the background of taking Metamizole sodium, and therefore, if unmotivated by Elevation of temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis requires immediate drug withdrawal. clarify the reason).