Baralgin M pills 500 mg 20 pcs
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Active ingredients
Metamizole Sodium
Release form
Pills
Composition
In 1 tab. active ingredient metamizole sodium. Excipients: macrogol 4000 - 47 mg, magnesium stearate - 3 mg.
Pharmacological effect
Anti-inflammatory, antipyretic, analgesic, antispasmodic. It blocks cyclooxygenase and reduces GHG synthesis.
Pharmacokinetics
After ingestion, it is hydrolyzed in the gastrointestinal tract with the formation of the active metabolite - 4-methylaminoantipirin (4-MMA), which is absorbed in the liver into 4-aminoantipyrine (4-AA), as well as pharmacologically inactive metabolites. After ingestion of 1 g of Metamizole, 58% 4-MMA and 48% 4-AA bind to plasma proteins. Effective therapeutic plasma concentration of 4-MMA is reached in 20–40 min, Cmax - in 2 h.
Indications
Pain syndrome of low and medium intensity (headache and toothache, neuralgia, pain in radiculitis, osteochondrosis, arthritis, menalgia), smooth muscle spasms (renal colic, biliary colic, intestinal colic), feverish states in infectious and inflammatory diseases (as part of a combined therapy)
Contraindications
Hypersensitivity to pyrazolones (including Metamizolizopropylaminophenazone, propyphenazone and phenazone-containing agents, phenylbutazone). Acute hepatic porphyria, congenital deficiency of glucose-6-phosphate dehydrogenase
Precautionary measures
Special care should be taken in case of arterial hypotension (systolic blood pressure below 100 mm Hg); in situations characterized by unstable systemic hemodynamic parameters (acute myocardial infarction, multiple trauma, incipient shock); in patients with a history of disorders of peripheral blood (for example, who received cytotoxic drugs) or hypersensitivity reactions to medicinal substances (food, preservatives, furs, hair dye), suffering from asthma and / or chronic infectious and inflammatory diseases of the respiratory tract , with hypersensitivity to any NSAIDs and antipyretic analgesics (the threat of asthma and shock); in infants of the first 3 months. life or with a body weight less than 5 kg (increased risk of developing renal dysfunction).It is not recommended to combine with drugs that cause intolerance reactions (x-ray contrast agents, plasma-substituting solutions, penicillins). With an unexpected deterioration in the general condition of the patient (fever, inflammation of the mucous membranes of the mouth, nose and throat, increased ESR), it is necessary to immediately cancel the reception. In case of anaphylactic shock, it is required to inject / slowly (slowly) a 0.1% solution of adrenaline (if necessary, again, at intervals of 15–30 min), then a glucocorticoid, antihistamines, replace blood volume, ventilator, heart massage
Use during pregnancy and lactation
Contraindicated in the I and III trimesters of pregnancy. Use in the II trimester - only under strict medical indications. Breastfeeding is contraindicated within 48 hours after taking Baralgin M
Dosage and administration
Inside, adults - 500-1000 mg 4 times a day. The maximum single dose - 1 g daily - 3 g.
Side effects
Agranulocytosis, leukopenia, thrombocytopenia, a sharp drop in blood pressure, transient impaired kidney function (oliguria or anuria, proteinuria), interstitial nephritis, allergic and immunopathological reactions (urticarial eruptions on the skin, conjunctiva, mucous membranes in the nasal pharynx; , anaphylactic shock)
Overdose
In case of overdose, consult a physician. The following symptoms may occur: nausea, vomiting, stomach pain, oliguria, hypothermia, low blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal or hepatic failure, convulsions, paralysis of the respiratory muscles. Treatment: induce vomiting, gastric lavage through a tube; saline laxatives, activated carbon; conducting forced diuresis, hemodialysis; with the development of convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.
Interaction with other drugs
Reduces the concentration of cephalosporin in the blood, enhances the effect of alcohol
special instructions
Removal with urine of one of the products of biotransformation may cause red staining of urine (has no clinical significance and disappears after withdrawal)