Cardionat-Stad capsule 250mg N40
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Active ingredients
Meldonius
Release form
Capsules
Composition
1 caps Meldonium dihydrate * 250 mg. Excipients: potato starch - 13.3 mg, colloidal silicon dioxide (aerosil) - 5.7 mg, calcium stearate - 2.7 mg.
Pharmacological effect
Means, improves metabolism, an analogue of gamma-butyrobetaine. Inhibits gamma-butyrobetaine hydroxinase, inhibits carnitine synthesis and transport of long-chain fatty acids through cell walls, prevents accumulation of activated forms of non-oxidized fatty acids - acylcarnitine and acylcoenzyme A. ATP at the same time activates glycolysis, which proceeds without additional consumption of oxygen. As a result of reducing the concentration of carnitine, gamma-butyrobetaine with vasodilating properties is intensively synthesized. The mechanism of action determines the diversity of its pharmacological effects: increasing efficiency, reducing the symptoms of mental and physical overstrain, activation of tissue and humoral immunity, cardioprotective effect. In the case of acute ischemic myocardial damage, it slows down the formation of a necrotic zone, shortens the rehabilitation period. In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of strokes. In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes the redistribution of blood in favor of the ischemic area. Effective with vascular and dystrophic pathology of the fundus. It has a tonic effect on the central nervous system, eliminates functional disorders of the nervous system in patients with chronic alcoholism with withdrawal syndrome.
Pharmacokinetics
After ingestion is rapidly absorbed from the digestive tract. Bioavailability is about 78%. Cmax in plasma is achieved within 1-2 hours after administration. Biotransformations in the body with the formation of two major metabolites, which are excreted by the kidneys. T1 / 2 is 3-6 hours and is dose dependent.
Indications
For oral or intravenous administration: as part of complex treatment of coronary artery disease (stenocardia, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy as part of complex therapy of acute and chronic cerebrovascular accidents (strokes and cerebrovascular insufficiency) reduced performance, physical over-exposure including athletes), the postoperative period to accelerate the rehabilitation of withdrawal syndrome in chronic alcoholism (in combination with specific therapy of alcoholism ma). For parabulbar administration: acute impaired blood circulation in the retina, hemophthalmia and retinal hemorrhage of various etiologies, thrombosis of the central vein of the retina and its branches, retinopathy of various etiologies (including diabetic and hypertensive) - only for parabulbar injection.
Contraindications
Increased intracranial pressure (including in violation of the venous outflow, intracranial tumors), pregnancy, lactation (breastfeeding), children and adolescents under 18 years of age, increased sensitivity to meldonium.
Dosage and administration
In connection with the possibility of an exciting effect, it is recommended to use it in the morning. Dose set individually depending on the evidence and route of administration. When ingested a single dose of 0.25-1 g, the multiplicity and duration of treatment depend on the evidence. With the / in the introduction of the dose is 0.5-1 g 1 time / day, the duration of treatment depends on the evidence. Parabulbar injected with 0.5 ml of solution for injection with a concentration of 500 mg / 5 ml for 10 days.