Coldrex Junior Hot Drink Powder 3g N10
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Active ingredients
Paracetamol + Phenylephrine + Ascorbic Acid
Release form
Powder
Composition
Paracetamol 300 mg, phenylephrine hydrochloride 5 mg, ascorbic acid 20 mg. Auxiliary substances: sodium saccharinate - 21.5 mg, sodium cyclamate - 31.5 mg, citric acid - 340 mg, sodium citrate - 215 mg, corn starch - 100 mg, sucrose - 1862.5 mg, lemon flavor 610399E - 100 mg, curcumin (E100) dye - 3.5 mg, colloidal silicon dioxide - 1 mg.
Pharmacological effect
Combined drug for the symptomatic treatment of acute respiratory diseases. Paracetamol has antipyretic, analgesic effect. Phenylephrine hydrochloride is a sympathomimetic, narrows the vessels of the nasal mucosa and the paranasal sinuses, resulting in reduced swelling and easier nasal breathing. and flu.
Pharmacokinetics
Data on the pharmacokinetics of Coldrex; Junior not provided.
Indications
To eliminate the symptoms of acute respiratory infections and flu in children aged 6-12 years, including: - increased body temperature; - headache; - chills; - pain in joints and muscles; - sensations of nasal congestion; - pain in the sinuses and in the throat.
Contraindications
- hypersensitivity to the components of the drug; - severe liver disease; - severe kidney disease; - diseases of the hematopoietic system; - thyrotoxicosis; - arterial hypertension; - heart disease (marked stenosis of the aorta mouth, acute myocardial infarction; tachyarrhythmia); - prostatic hyperplasia; - angle-closure glaucoma; - diabetes mellitus; - genetic absence of glucose-6-phosphate dehydrogenase; - sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, since the preparation contains sucrose; - simultaneous administration of tricyclic antidepressants, beta-blockers, MAO inhibitors and a period of up to 14 days after their withdrawal; - children up to 6 years.
Precautionary measures
Do not exceed the recommended dose. With caution, you should use the drug for benign hyperbilirubinemia, pheochromocytoma, peripheral vascular disease (Raynaud's syndrome).
Dosage and administration
Children from 6 to 12 years old should be prescribed 1 sachet every 4 hours. Do not use more than 4 sachets for 24 hours. Do not exceed the specified dose. The maximum duration of use is no more than 5 days. If symptoms persist, consult a doctor. The doctor determines the need for continuation of treatment individually. Pour the contents of 1 sachet into a mug, pour about 125 ml of hot water, stir until dissolved. If necessary, add cold water and sugar.
Side effects
In recommended doses, the drug is usually well tolerated. Paracetamol rarely has side effects. With prolonged use, exceeding the recommended dose, hepatotoxic and nephrotoxic effects can be observed. From the hematopoietic system: very rarely - thrombocytopenia. ; very rarely - anaphylaxis, hypersensitivity reactions, incl. angioedema, Stevens-Johnson syndrome. In the respiratory system: very rarely - bronchospasm in patients sensitive to acetylsalicylic acid and other NSAIDs. In the digestive system: very rarely - nausea, vomiting, abnormal liver function. In the CNS: very rare - dizziness, headache, insomnia. From the sense organs: rarely - mydriasis, acute glaucoma attack in most cases in patients with angle-closure glaucoma. From the side of the cardiovascular system: rarely - tachycardia, palpitations , increase in blood pressure. From the urinary system: very rarely - dysuria, urinary retention in patients with obstruction of the outlet of the bladder with hypertrophy of the prostate gland. In case of occurrence of any adverse reactions, the patient should consult a doctor.
Overdose
In case of drug overdose Coldrex; Junior (even with good health) should take into account the risk of delayed signs of serious damage to the liver. Symptoms caused by paracetamol: within 24 hours - pale skin, loss of appetite, nausea, vomiting, abdominal pain. After 12-48 hours, signs of impaired liver function, signs of impaired glucose metabolism and metabolic acidosis may appear. In case of severe poisoning, severe hepatic failure may develop, up to hepatic encephalopathy, coma and death.Acute renal failure with acute necrosis of the tubules, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, can develop without severely impaired liver function. There are reports of cases of cardiac arrhythmia and pancreatitis with paracetamol overdose. In the early period, symptoms may be limited only to nausea and vomiting and may not reflect the severity of the overdose or the risk of damage to internal organs. inside. After 4 or more hours after the presumptive overdose, it is necessary to determine the concentration of paracetamol in plasma (an earlier determination of the concentration of paracetamol may be unreliable). Acetylcysteine is a specific antidote for paracetamol poisoning. Treatment with acetylcysteine can be carried out up to 24 hours after taking paracetamol, however, the maximum hepatoprotective effect can be obtained in the first 8 hours after an overdose. After that, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine can be administered in / in. In the absence of vomiting, an alternative option (in the absence of the possibility of quickly receiving inpatient care) is the appointment of methionine inside. Patients with severe liver dysfunction 24 hours after taking paracetamol should be treated in conjunction with specialists from a toxicology center or specialized department of liver diseases. Symptoms caused by phenylephrine: irritability, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, increased excitability, reflex bradycardia. In severe cases of overdose may develop hallucinations, confusion, convulsions, arrhythmias. Treatment: symptomatic therapy, with severe arterial hypertension, the use of alpha-blockers such as phentolamine. Symptoms caused by ascorbic acid: ascorbic acid in high doses (more than 3000 mg) cause temporary osmotic diarrhea and gastrointestinal disorders, such as nausea, discomfort in the stomach. Manifestations of ascorbic acid overdose can be categorized as those caused by severe liver damage as a result of paracetamol overdose. Treatment: symptomatic, forced diuresis.
Interaction with other drugs
Paracetamol, when taken for a long time, enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Episodic administration of a single dose of the drug does not have a significant effect on the effect of indirect anticoagulants. Indications of anti-CI antioxidation in the liver (barbiturates, diphenine, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenybutazone, tricyclic antihydrin, antihydrogen, phenytocin, tricyclic fraction, antihydrogen, phenytoin, ethanol, flumecinol, phenytozonone, tricyclic fraction, antihydrogen, antihypertensives when taken with paracetamol. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic action. Paracetamol reduces the effectiveness of diure metoclopramide and domperidone increase, and colestyramine reduces the rate of absorption of paracetamol. Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol. Phenylephrine when taken with MAO inhibitors can lead to an increase in blood pressure. Phenylephrine reduces the effectiveness of beta-adrenoblockers and anti-MAO can lead to an increase in blood pressure. risk of developing hypertension and disorders of the cardiovascular system. Tricyclic antidepressants increase sympathomimetic action Wie phenylephrine may increase the risk of side effects razvitiyapobochnyh cardiovascular sistemy.Odnovremennoe use of halothane with phenylephrine increases the risk of ventricular aritmii.Fenilefrin reduce the hypotensive effect of guanethidine, which, in turn, increases the activity of alpha-adrenostimuliruyuschee fenilefrina.Antidepressanty, antiparkinsonian agents, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation. Simultaneous administration of GCS with phenylephrine increases the risk of developing glaucoma. When used simultaneously with digoxin and cardiac glycosides, the risk of developing heart rhythm disorders or a heart attack can be increased. Ascorbic acid while using iron preparations, due to its regenerating properties, translates ferric iron into bivalent,which helps to improve its absorption. When used simultaneously, ascorbic acid increases the excretion of iron in patients receiving deferoxamine. When used simultaneously with barbiturates, primidone increases the excretion of ascorbic acid in the urine. Ascorbic acid in high doses can reduce urine pH, which, when used simultaneously, reduces the canalic acid reabsorption of amphetamine and tricyclic antidepressants. With simultaneous use of acetylsalicylic acid reduces the absorption of ascorbic acid pr tret.Pri uniformly on the simultaneous use of warfarin may decrease varfarina.Pri effects simultaneously with application of increased tetracycline excretion of ascorbic acid in urine.
special instructions
The drug should not be taken simultaneously with other drugs containing paracetamol, as well as other non-narcotic analgesics (metamizole sodium), NSAIDs (acetylsalicylic acid, ibuprofen), with other means to alleviate the symptoms of cold and flu, sympathomimetics (such as decongestants, suppressant drugs) , amphetamine-like psychostimulants), barbiturates, anticonvulsant drugs, rifampicin, and chloramphenicol. When testing for uric acid The notes and the blood glucose level should be reported to your doctor about the use of the drug Coldrex; Junior, because The drug may distort the results of laboratory tests assessing the concentration of glucose and uric acid. Before taking the drug, you should consult a doctor if: - taking metoclopramide, domperidone (used to eliminate nausea and vomiting) or colestiramine, used to reduce the concentration of cholesterol in the blood; - taking drugs to reduce blood clotting (for example, warfarin); - observance of the diet with low sodium content - each bag contains 0.12 g of sodium. To avoid toxic damage to the liver pa racetamol should not be combined with drugs containing ethanol. Effects on the ability to drive vehicles and mechanisms If dizziness occurs, the patient should refrain from driving or other potentially hazardous activities that require concentration and psychomotor speed.