CREON 25,000 capsules 20 pieces
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Active ingredients
Pancreatin
Release form
Capsules
Composition
Active ingredient: Pancreatin (Pancreatin) Active ingredient concentration (mg): 300 mg
Pharmacological effect
Enzyme agent. Contains pancreatic enzymes - amylase, lipase and proteases, which facilitate the digestion of carbohydrates, fats and proteins, which contributes to their more complete absorption in the small intestine. In diseases of the pancreas, it compensates for the insufficiency of its exocrine function and contributes to the improvement of the digestive process.
Pharmacokinetics
The pharmacokinetics of pancreatin has not been studied.
Indications
Insufficiency of exocrine pancreatic function (including in chronic pancreatitis, cystic fibrosis). Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder; conditions after resection or irradiation of these organs, accompanied by impaired food digestion, flatulence, diarrhea (as part of combination therapy). In order to improve food digestion in patients with normal gastrointestinal function in case of errors in nutrition, as well as violations of chewing function, forced by prolonged immobilization, sedentary lifestyle. Preparation for X-ray and ultrasound of the abdominal organs.
Contraindications
Acute pancreatitis. Hypersensitivity to pancreatin.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
The safety of using pancreatin during pregnancy has not been studied enough. Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus. In experimental studies, it was found that pancreatin does not have a teratogenic effect.
Dosage and administration
The maximum daily dose is 15 000 IU / kg. Children under the age of 1.5 years - 50 000 IU / day; older than 1.5 years - 100 000 IU / day. The duration of treatment can vary from several days (if the digestive process is disturbed due to errors in the diet) to several months or even years (if necessary, constant replacement therapy).
Side effects
On the part of the digestive system: in some cases - diarrhea, constipation, feeling of discomfort in the stomach, nausea. The causal relationship between the development of these reactions and the action of pancreatin has not been established, sincethese phenomena are symptoms of exocrine pancreatic insufficiency. Allergic reactions: in some cases - skin manifestations. Metabolism: long-term use in high doses may develop hyperuricuria, in excessively high doses - an increase in plasma uric acid levels. Other: with the use of pancreatin in high doses in children, perianal irritation may occur.
Overdose
Overdose of the drug is not described.
Interaction with other drugs
With simultaneous use with antacids containing calcium carbonate and / or magnesium hydroxide, it is possible to decrease the effectiveness of pancreatin. With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.
special instructions
It is not recommended to use in the acute phase of chronic pancreatitis. In cystic fibrosis, the dose should be adequate to the amount of enzymes that are necessary for fat absorption, taking into account the quality and quantity of food consumed. lipase) due to an increased risk of stricture development (fibrous colonopathy) in the ileo-cecal and in the ascending colon. With a high activity of the lipase contained in pancreatin, the likelihood of nce of constipation in children. Increasing the dose of pancreatin in this category of patients should be carried out gradually. Violations of the digestive system can occur in patients with hypersensitivity to pancreatin, or in patients with meconium ileus or bowel resection in history.