Ercefuryl Capsules 200mg N14
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Active ingredients
Nifuroxazide
Release form
Capsules
Composition
Active ingredient: Nifuroksazid Auxiliary substances: Sucrose 72.0 mg, Magnesium stearate 1.8 mg, Cornstarch 88.0 mg Concentration of the active substance (mg): 200 mg
Pharmacological effect
Like other nitrofurans, nifuroxazide blocks some redox enzyme reactions in microbial cells. when used in therapeutic doses has a bacteriostatic effect, in high doses - bactericidal. highly active against campylobacter jejuni, escherichia coli, salmonella spp., shigella spp .; clostridium perfringens, vibrio cholerae, pathogenic vibrions and vibrio parahaemolytic, staphylococcus spp. are weakly sensitive to nifuroxazide: citrobacter spp., enterobacter cloacae, and proteus indologenes.resistant to nifuroxazide: klebsiella aethe, 17-year-old, etc. on saprophytic flora (does not cause dysbiosis). resistance of microorganisms to the drug does not develop.
Pharmacokinetics
Nifuroxazide is practically not absorbed from the gastrointestinal tract, 99% of the dose taken remains in the intestine and has its antimicrobial effect there. Nifuroxazide is eliminated through the intestines: 20% unchanged, and the rest nifuroxazide is chemically altered.
Indications
Acute bacterial diarrhea.
Contraindications
Hypersensitivity (including to other derivatives of nitrofuran); children's age up to 6 years.
Precautionary measures
The drug should be kept out of the reach of children, in a dry place at a temperature not higher than 30 ° C.
Use during pregnancy and lactation
In animal studies, nifuroxazide showed no teratogenic effect. However, as a precautionary measure, taking nifuroxazide during pregnancy is not recommended (insufficient clinical experience with pregnancy). During the lactation period, breastfeeding may be continued in case of a short course of drug treatment.
Dosage and administration
Inside, adults - 1 cape. 4 times a day (800 mg). For children over 6 years old, 200 mg 3 times a day (600 mg). Duration of treatment is no more than 7 days.
Side effects
Allergic reactions such as skin rashes, hives, angioedema, or anaphylactic shock are rarely possible.
Overdose
Data on overdose Ercefuryl not available.
Interaction with other drugs
Data on drug interactions drug Ercefuryl not available.
special instructions
In the case of bacterial diarrhea with signs of systemic damage (worsening of the general condition, fever, symptoms of intoxication or infection), antibacterial drugs with good systemic diffusion should be used. In case of severe, prolonged diarrhea, severe vomiting or if you refuse to eat, you should consider intravenous the introduction of fluid and electrolytes for rehydration. If the treatment of diarrhea persists for more than 2 days, treatment should be reviewed and the need for liquid stey and electrolytes inside or / in the introduction. The volume of fluid injected and the method of its introduction (orally, in / in) must correspond to the severity of diarrhea, age and clinical condition of the patient. Effect on the ability to drive vehicles and control mechanisms The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities .