Chondroxide coated pills 250mg N60
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Active ingredients
Chondroitin sulfate
Release form
Pills
Composition
1 tablet contains: Active substance: chondroitin sodium sulfate 250 mg Auxiliary substances: calcium stearate monohydrate (calcium 1-water stearate) - 4.8 mg, crospovidone (polyplasdone XL-10, collidon CL-M) - 12.39 mg, povidone K30 (collidon 30) - 9.312 mg, microcrystalline cellulose - 96 mg, magnesium hydroxycarbonate pentahydrate (basic magnesium carbonate water) - 107.498 mg.
Pharmacological effect
A drug that regulates the metabolism of cartilage tissue. It has chondrostimulating, regenerating and anti-inflammatory effects. Chondroxide; participates in the construction of the main substance of cartilage and bone tissue. Affects metabolic processes in hyaline and fibrous cartilage. It inhibits degenerative processes in cartilage and connective tissue, inhibits enzymes that cause damage to cartilage tissue. Chondroxide; stimulates the biosynthesis of proteoglycans, promotes the regeneration of the articular sacs and the cartilaginous surfaces of the joints, increases the production of intra-articular fluid, and has anti-inflammatory effect Slows bone resorption and reduces calcium loss, accelerates bone repair processes. Chondroxide; slows the progression of osteoarthritis and osteochondrosis. The use of the drug reduces pain and improves the mobility of the affected joints, while the therapeutic effect lasts a long time after the end of the course of therapy.
Pharmacokinetics
With a single oral administration, the average therapeutic dose of Tmax in plasma is 3-4 hours, Tmax in synovial fluid is 4-5 hours. Bioavailability is 13%. It accumulates mainly in cartilage (Tmax in articular cartilage is 48 hours): the synovial membrane not an obstacle to the penetration of the drug into the joint cavity. Excreted by the kidneys within 24 hours
Indications
Degenerative-dystrophic diseases of the joints and spine: - treatment and prevention of osteoarthritis, spinal osteochondrosis.
Contraindications
- pregnancy; - lactation period; - hypersensitivity to the drug components.
Precautionary measures
With caution should use the drug for bleeding or with a tendency to bleed.
Use during pregnancy and lactation
Use of the drug is contraindicated during pregnancy and lactation.
Dosage and administration
The drug should be taken orally on 500 mg (2 tab.) 2 times / day, with a small amount of water. The recommended duration of the initial course of treatment is 6 months. The therapeutic effect of the drug lasts for 3-5 months after its cancellation, depending on the location and stage diseases. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is determined individually.
Side effects
In some cases: allergic reactions, nausea, diarrhea.
Overdose
Symptoms: rarely - nausea, vomiting, diarrhea, with prolonged use in excessively high doses (more than 3 g / day) hemorrhagic rashes are possible. Treatment: conducting symptomatic therapy.
Interaction with other drugs
Perhaps increasing the effect of indirect anticoagulants, antiplatelet agents, fibrinolitikov.
special instructions
When used together with indirect anticoagulants, antiplatelet agents, fibrinolytics, more frequent monitoring of blood coagulation parameters is required. Pediatric useEfficiency and safety of chondroitin sulfate use in children have not been established. Influence on ability to drive vehicles and control mechanisms Does not affect the ability to drive vehicles and other mechanisms.