METROMICON-NEO vaginal suppositories N14
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Active ingredients
Metronidazole + Miconazole
Release form
Suppositories
Composition
1 supp. metronidazole 500 mg miconazole 100 mg.
Pharmacological effect
Metronidazole is a 5-nitroimidazole and is a drug with a bactericidal type of action, exhibiting tropism (ability of interaction) to deoxyribonucleic acid. The mechanism of action consists in the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5-nitro group of metronidazole interacts with the deoxyribonucleic acid of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. Active against protozoa: Trichomonas vaginalis, Entamoeba histolytica, as well as obligate anaerobic bacteria: Gram-negative - Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), gram-positive - Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp :, Mobiluncus spp. and facultative anaerobes - Gardnerella vaginalis. To metronidazole, aerobic microorganisms are insensitive, but in the presence of mixed flora (aerobes, and anaerobes), metronidazole acts synergistically with antibiotics that are effective against ordinary aerobes. Miconazole is an antifungal agent derived from azole. Intravaginal administration is active mainly against Candida albicans. The fungicidal and fungistatic effect of miconazole is due to the inhibition of the biosynthesis of ergosterol membrane and plasma membranes of fungi, changes in the lipid composition and permeability of the cell wall, causing the death of the fungal cell.
Indications
Vaginal infections: - Vaginal candidiasis. - Trichomonas vaginitis and vulvovaginitis, bacterial vaginosis. - mixed vaginal infection.
Contraindications
- hypersensitivity to the components of the drug or other nitroimidazole derivatives - I trimester of pregnancy, lactation period, - children under 18 years old - in virgins. With caution: with hepatic and renal failure, porphyria, impaired blood formation and diseases of the peripheral and central nervous system, diabetes, microcirculation disorders, during pregnancy (II and III trimesters).
Use during pregnancy and lactation
The purpose of the drug is contraindicated in the first trimester of pregnancy.Application in the II and III trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the possible risk to the fetus. If necessary, the appointment of the drug during lactation breastfeeding should be discontinued, since metronidazole penetrates into breast milk. Breastfeeding can be resumed 24-48 hours after the end of treatment.
Dosage and administration
Intravaginally. Acute vaginitis, bacterial vaginosis: 1 suppository, in the morning and at night for 7 consecutive days. Chronic vaginitis: 1 suppository 1 time per day, immediately before bedtime, for 14 consecutive days. Often recurrent vaginitis or in the absence of positive clinical dynamics in the treatment of other methods: 1 suppository in the morning and at night for 14 days. Before freeing the suppository from the contour packaging using scissors (cut the film along the contour of the suppository), insert it deeply into the vagina.
Side effects
Local reactions: burning, itching, irritation of the mucous membrane of the vagina and increased swelling. Due to inflammation of the vaginal mucosa with vaginitis, irritation may increase after the introduction of the first suppository or by the third day of treatment. These complications quickly disappear after stopping treatment. On the part of the gastrointestinal tract: pain or cramps in the stomach, "metallic" taste, dry mouth, constipation, diarrhea, loss of appetite, nausea, vomiting. From the nervous system: headache, movement disorders (ataxia), dizziness, psycho-emotional disorders, convulsions. From the hemopoietic system: leukopenia. Allergic reactions: skin rashes, including urticaria.
special instructions
Local reactions: burning, itching, irritation of the mucous membrane of the vagina and increased swelling. Due to inflammation of the vaginal mucosa with vaginitis, irritation may increase after the introduction of the first suppository or by the third day of treatment. These complications quickly disappear after stopping treatment. On the part of the gastrointestinal tract: pain or cramps in the stomach, "metallic" taste, dry mouth, constipation, diarrhea, loss of appetite, nausea, vomiting. From the nervous system: headache, movement disorders (ataxia), dizziness, psycho-emotional disorders, convulsions.From the hemopoietic system: leukopenia. Allergic reactions: skin rashes, including urticaria.