Mezim Forte N20 coated pills
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Active ingredients
Pancreatin
Release form
Pills
Composition
Pancreatin with minimal enzymatic activity: lipase 3500 IU Ph.Eur, amylase 4200 IU Ph.Eur, proteases 250 IU Ph.Eur. Excipients: microcrystalline cellulose, sodium carboxymethyl starch (type A), colloidal silicon dioxide, magnesium stearate. The composition of the shell: talc, hypromellose, azorubic varnish (E122), simethicone emulsion 30% (dry weight), polyacrylate dispersion 30% (dry weight) , titanium dioxide (E171), macrogol 6000.
Pharmacological effect
The drug compensates for the insufficiency of the exocrine function of the pancreas. The enzymes lipase, amylase and protease, which are part of pancreatin, facilitate the digestion of fats, carbohydrates and proteins, which contributes to their more complete absorption in the small intestine.
Indications
- insufficiency of the exocrine function of the pancreas, (chronic pancreatitis, cystic fibrosis) - chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder. Conditions after resection or irradiation of these organs, accompanied by impaired digestion disorders, flatulence, diarrhea (as part of combination therapy) - to improve food digestion in patients with normal gastrointestinal function in case of errors in nutrition — preparation for X-ray and ultrasound of the abdominal cavity.
Contraindications
- hypersensitivity to the drug components; - acute pancreatitis; - exacerbation of chronic pancreatitis.
Use during pregnancy and lactation
The safety of using pancreatin during pregnancy has not been studied enough. Application is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Dosage and administration
The dose is determined individually depending on the degree of digestive disorders. Adults: 1-2 tab. before eating, without chewing and drinking water. If necessary, in addition during the meal take another 1-4 tab. In children, the drug is used as prescribed by a doctor. The duration of treatment can vary from several days (in case of disturbance of the digestive process due to errors in the diet) to several months or years (if necessary, constant replacement therapy).
Side effects
Allergic reactions, diarrhea or constipation, nausea, epigastric discomfort. With prolonged use in high doses may develop hyperuricuricuria, an increase in the level of uric acid in the blood plasma. In isolated cases, patients suffering from cystic fibrosis, the formation of strictures in the ileocecal region after receiving high doses.
Interaction with other drugs
With simultaneous use of pancreatin with iron preparations may decrease the absorption of the latter. The simultaneous use of antacid agents containing calcium carbonate and / or magnesium hydroxide, can lead to a decrease in the effectiveness of pancreatin.