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Active ingredients
Nystatin
Release form
Pills
Composition
One tablet film coated contains: Active substance: acyclovir 400 mg. Excipients: tablet core: povidone, sodium carboxymethyl starch, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate. tablet shell: Opadry Pink OY-24926 (composition: hypromellose, titanium dioxide, macrogol, iron dye red oxide, iron dye yellow oxide).
Pharmacological effect
Antifungal drug from the group of polyenes. Binding to the sterols in the cell membrane of fungi, violates its permeability, which leads to the release of the main components of the cell. It has a fungistatic effect. Active against yeast-like fungi of the genus Candida.
Pharmacokinetics
It has a weak resorptive effect (almost not absorbed in the digestive tract). Excreted through the intestines. Does not accumulate.
Indications
Treatment and prevention of gastrointestinal candidiasis. Prevention of fungal lesions in the pre- and postoperative periods during surgical interventions in the gastrointestinal tract.
Contraindications
Hypersensitivity to the active substance or any other component of the drug, children under 13 years of age (for this dosage form).
Precautionary measures
Do not use for the treatment of systemic mycoses. It is necessary to complete the full course of therapy. It is necessary to strictly observe the regimen and treatment regimen for the entire course, take the drug at regular intervals and not skip the dose. If you skip a dose, you should take it as soon as possible, but if the time for taking the next dose has come, do not take a double dose to replace the missed dose. Nystatin can increase the skin's sensitivity to sun exposure, therefore, during treatment, direct sunlight and artificial ultraviolet radiation should be avoided. The drug contains sugar. Patients with rare hereditary diseases of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase deficiency should not take the drug. When the adverse reactions develop, the drug should be discontinued. The effect on the ability to drive motor vehicles and other potentially dangerous mechanisms.When taken in therapeutic doses, nystatin does not affect the ability to drive vehicles and machinery.
Use during pregnancy and lactation
Despite the fact that nystatin in the gastrointestinal tract is absorbed in small quantities, it is still unknown whether taking a drug by a pregnant woman can harm the fetus. The use of the drug is possible only if the intended benefit to the mother outweighs the possible risk to the fetus or infant. It is not known whether nystatin is excreted in breast milk; therefore, if it is necessary to use it during lactation, the question of discontinuing breastfeeding should be decided.
Dosage and administration
Inside, regardless of the meal. Adults appoint 500000 IU 3-4 times. The daily dose is 1500000-3000000 IU, in severe cases up to 4,000,000-6,000,000 IU. Duration of treatment is 2 weeks or as long as treatment with drugs that promote the growth of Candida continues. Children over 13 years old - 500,000 IU 3-4 times a day. The duration of treatment is 10-14 days. If necessary, treatment time may be extended. The pills are swallowed without chewing. This dosage form is not intended for children under 13 years of age. For patients in this age group should be intended suspension.
Side effects
On the part of the digestive system: bitter taste in the mouth, dyspepsia, nausea, vomiting, gastralgia, diarrhea. Allergic reactions: fever, chills, rash, urticaria, itching, bronchospasm, angioedema, including swelling of the face, rarely Stevens-Johnson syndrome. Other: photosensitivity, tachycardia, nonspecific myalgia; possible risk of spreading resistant forms of fungi, which requires discontinuation of the drug. Contraindications Hypersensitivity to the active substance or any other component of the drug. Overdose Overdose phenomena with the use of the drug have not been described to date.
Overdose
Phenomena of overdose with the use of the drug has not yet been described.
Interaction with other drugs
With the simultaneous use of nystatin with clotrimazole activity of the latter is reduced.
special instructions
With the development of adverse reactions should reduce the dose or cancel the drug. During menstruation, you should not interrupt the treatment with vaginal suppositories. For fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During treatment, sexual intercourse should be avoided.