Panzinorm Forte 20,000 coated pills soluble in the intestines N30
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Pancreatin
Release form
Coated pills
Composition
Active ingredient: Pancreatin (Pancreatin) Active ingredient concentration (mg): 269.12 - 279.44
Pharmacological effect
Enzyme preparation. Compensates insufficiency of the exocrine function of the pancreas. The action of the drug due to its constituent components. High lipase activity plays an important role in the treatment of maldigestia caused by pancreatic enzyme deficiency. Lipase breaks down fats by hydrolysis to fatty acids and glycerol, thus, contributes to their absorption and absorption of fat-soluble vitamins. Amylase breaks down carbohydrates into dextrins and sugars, while protease breaks down proteins. The tablet has a protective shell, through which the active enzymes contained in the tablet are released in the small intestine, where pancreatic enzymes act. fats, carbohydrates and proteins, which contributes to their more complete absorption in the small intestine. Eliminates the symptoms resulting from digestive disorders (feeling of heaviness and overfilling of the stomach, flatulence, feeling of lack of air, shortness of breath due to gas accumulation in the intestines, diarrhea). Improves the process of digestion in children; stimulates the secretion of its own enzymes of the pancreas, stomach and small intestine, as well as bile.
Pharmacokinetics
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, since protected from the action of gastric juice film coating. A minor part of the digestive enzymes is secreted through the intestines.
Contraindications
hypersensitivity to porcine protein or other components of the drug, acute pancreatitis, exacerbation of chronic pancreatitis, children under 3 years old (for this dosage form) and up to 15 years (for children suffering from cystic fibrosis).
Use during pregnancy and lactation
In case of cystic fibrosis, if the required dose of pancreatin is exceeded (more than 10,000 IU Ph. Eur. Lipase per 1 kg of body weight), strictures (fibrous colonopathy) may develop in the ileocecal region and in the ascending colon.Therefore, in cystic fibrosis, the dose must be adequate to the amount of enzymes that are necessary for the absorption of fat, taking into account the quality and quantity of food consumed.
Dosage and administration
Inside, while eating. Tablets should be taken whole without chewing, with a sufficient amount of liquid. The dose and duration of therapy is determined individually depending on the age and degree of pancreatic insufficiency. per day, during each main meal. Pansinorm Forte 20,000 pills can be taken while taking a light snack. If necessary, a single dose is increased by 2 times. The average daily dose is 1–2 pills 3 times. Before X-ray and ultrasound studies, 2 pills 2–3 times a day, 2–3 days before the examination. In children, the drug is used as prescribed by a doctor. Children over the age of 3 - 100 thousand U / day (in terms of lipase). The duration of treatment can vary from a single dose or several days (if the digestive process is disturbed due to errors in the diet) to several months or years (if necessary, constant replacement therapy ).
Side effects
With simultaneous use with pancreatin may decrease the absorption of iron preparations (clinically insignificant) and folic acid. It is recommended to periodically monitor folate levels and / or folic acid administration. The acid-resistant coating of Panzinorm Forte 20,000 pills dissolves in the duodenum. At low pH in the duodenum, pancreatin is not released. The simultaneous use of histamine H2-receptor blockers (cimetidine), antacid drugs (bicarbonates), proton pump inhibitors can lead to an increase in the effectiveness of pancreatin.
Overdose
Allergic reactions: skin hyperemia, skin rash, skin itching, sneezing, choking, tearing. On the part of the digestive system (with prolonged intake in large doses): nausea, vomiting, abdominal pain (includingintestinal colic), diarrhea, constipation, perianal irritation, irritation of the oral mucosa. In case of cystic fibrosis in case of exceeding the required dose of pancreatin (more than 10,000 IU of Evr. Pharm. Lipase per 1 kg of body weight), strictures (fibrous colonopathy) may develop in the ileocecal region and in the ascending colon.
Interaction with other drugs
Precautionary measures
special instructions
Symptoms: nausea, vomiting, diarrhea, hyperuricosuria, hyperuricemia, perianal irritation, fibrous colonopathy (with cystic fibrosis). Treatment: drug withdrawal, hydration, symptomatic therapy.