Phenibut pills 250mg N20 (OlainFarm)
Condition: New product
952 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Aminophenylbutyric acid
Release form
Pills
Composition
1 tablet contains: active substance: γ-amino-β-phenylbutyric acid hydrochloride 250 mg
Pharmacological effect
Tranquilizer, gamma-aminobutyric acid derivative (GABA) and phenylethylamine. Does not affect cholino and adrenoreceptors. It eliminates tension, anxiety, fear, improves sleep. The drug shortens the duration and severity of nystagmus. It has anticonvulsant action. Phenibut reduces the manifestations of asthenia and vasic-vegetative symptoms, including headache, feeling of heaviness in the head, irritability, emotional lability, increases mental performance. Attention, memory, speed and accuracy of sensory motor reactions under the influence of Phenibut are improved. It is established that when Phenibut is used for traumatic brain injury, the number of mitochondria in the cells located hearth lesion. Phenibut also has an antioxidant effect.
Pharmacokinetics
The absorption of the drug is high, it penetrates well into all tissues of the body and through the blood-brain barrier (BBB). About 0.1% of the injected dose of the drug penetrates into the brain tissue, and in young and old people to a much greater extent. Evenly distributed in the liver and kidneys. Metabolized in the liver -80-95%, metabolites are not pharmacologically active. Not cumulated. After 3 hours, it begins to be excreted by the kidneys, while the concentration in the brain tissue does not decrease and is found in the brain for an additional 6 hours. About 5% is excreted by the kidneys unchanged, partly with bile.
Indications
Asthenic and anxiety-neurotic states, anxiety, fear, obsessive-compulsive disorder, psychopathy. Stuttering and tics in children, enuresis. Retention of urine on the background of myelodysplasias. Insomnia and nightmares in the elderly. Prevention of anxiety states that arise before surgical interventions and painful diagnostic studies (sedation). Meniere's disease, dizziness associated with dysfunctions of the vestibular analyzer of various origins (including with otogenic labyrinthitis, vascular and traumatic disorders). prevention of kinetozakh. Primary open-angle glaucoma (as part of combination therapy).As an auxiliary therapy in the treatment of alcoholism (for stopping psychopathological and somatovegetative disorders with withdrawal syndrome). Treatment of precririous and delirious conditions in alcoholism (in combination with conventional detoxification agents).
Contraindications
Individual intolerance Phenibut. Pregnancy. Breastfeeding period. Hepatic insufficiency.
Precautionary measures
It is used with caution in patients with a state of alcohol withdrawal with convulsions in history, as well as in patients with severe traumatic brain injury.
Use during pregnancy and lactation
During pregnancy and lactation Phenibut can be used, but only with a ratio of benefits and risks for mother and child.
Dosage and administration
Phenibut is applied orally before meals, in a course of 4-6 weeks. Adults use the drug at an average dose of 250-500 mg 3 times / day; if necessary, increase the dose to 2.5 g / day. The maximum single dose - 750 mg, for persons over 60 years old - 500 mg. Children from 2 to 8 years old - 50-100 mg 3 times / day, the maximum single dose - 150 mg; children 8-14 years old - 250 mg 3 times / day, the maximum single dose - 300 mg. For the relief of alcohol withdrawal syndrome in the first days of therapy, the drug is prescribed 250-500 mg 3 times a day and 750 mg at night, with a gradual decrease in the daily dose to the usual for adults. In otogenic labyrinth and Meniere's disease in the period of exacerbation - 750 mg 3-4 times / day for 5-7 days, while reducing the severity of vestibular disorders - 250-500 mg 3 times / day for 5-7 days and then 250 mg 1 time / day for 5 days. In case of mild disease, 250 mg 2 times / day for 5-7 days, followed by dose reduction to 250 mg 1 time / day for 7-10 days. For the treatment of dizziness in case of disorders of the vestibular apparatus of the vascular and traumatic genesis - 250 mg 3 times / day for 12 days. For the prevention of kinetoz - 250-500 mg once for 1 hour before the intended journey (the effect is dose-dependent).
Side effects
On the part of the central nervous system, increased irritability, agitation, anxiety, dizziness, headache, drowsiness. On the part of the digestive system, nausea (at the first dose). Allergic reactions skin rash, itching.
Overdose
Increased symptoms of side effects: severe drowsiness, nausea, vomiting, fatty liver (taking more than 7 g), eosinophilia, lowering blood pressure, impaired renal function. First aid - gastric lavage, taking activated carbon and conducting symptomatic therapy.
Interaction with other drugs
In order to mutually potentiate, Phenibut can be combined with other psychotropic drugs, reducing the doses of Phenibut and the drugs that are combined with it. Lengthens and strengthens the effect of hypnotic drugs, narcotic, neuroleptic and anticonvulsant drugs, alcohol. There is evidence of an increase in the action of antiparkinsonian drugs under the influence of the drug Fenibut.
special instructions
Phenibut is used with caution in erosive and ulcerative lesions of the gastrointestinal tract, liver failure. With long-term use of Phenibut, it is necessary to monitor indicators of liver function and peripheral blood picture. refrain from potentially hazardous activities requiring increased attention and high-speed psychomotor reactions.