Presartan pills 50 mg 30 pcs
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Active ingredients
Losartan
Release form
Pills
Composition
Losartan potassium 50 mg; Excipients: dried starch, microcrystalline cellulose, purified talc, colloidal silicon dioxide (Aerosil-200), sodium starch glycolate (primogel), magnesium stearate, isopropanol, methylene chloride, Opadry OY-55030, dyed powder Lake of Ponceau.
Pharmacological effect
Antihypertensive drug, a specific angiotensin type II receptor antagonist (AT2). He inhibits kinase II - an enzyme that destroys bradykinin. Decreases round fist, reduces afterload, reduces systemic blood pressure and pressure in the pulmonary circulation.
Pharmacokinetics
Absorption; After taking the drug inside, losartan is well absorbed from the gastrointestinal tract. Bioavailability is about 33%; Distribution and metabolism; Exposed to the effect of "first pass" through the liver. The degree of binding to plasma proteins of losartan and its metabolite is 92-99%. No accumulation .; Withdrawal; T1 / 2 is 2 hours. Losartan is excreted in the urine and bile.
Indications
- arterial hypertension; - Ischemic heart disease, accompanied by symptoms of heart failure (in combination therapy with diuretics and cardiac glycosides).
Contraindications
- children's and teenage age up to 18 years; - pregnancy; - hypersensitivity to the drug.
Use during pregnancy and lactation
The drug is contraindicated for use in pregnancy .; It is not known whether losartan is excreted in breast milk. If the appointment of Presartan is necessary during lactation, a decision should be made to stop breastfeeding.
Dosage and administration
In case of arterial hypertension, the initial daily dose of the drug is 25 mg, the average daily dose is 50 mg, the dose is 1 time per day; The maximum hypotensive effect develops 3-6 weeks after starting the drug. If necessary, the dose can be increased to 100 mg / day, while the drug can be taken 2 times / day; With heart failure, the initial dose is 12.5 mg 1 time / day. As a rule, the dose is titrated with a weekly interval (ie, 12.5 mg / day, 25 mg / day, 50 mg / day) to an average maintenance dose of 50 mg 1 time / day, depending on the tolerance of therapy .; When prescribing the drug to patients receiving diuretics in high doses, the initial dose should be reduced to 25 mg 1 time per day; Patients with impaired liver function should be given losartan in lower doses .; In the elderly,as well as in patients with impaired renal function, including those on hemodialysis, there is no need for correction of the initial dose of the drug .; Presartan can be prescribed in conjunction with other antihypertensive drugs .; Tablets can be taken regardless of the meal.
Side effects
On the part of the digestive system: diarrhea, dyspepsia; rarely, increased liver transaminase activity and blood bilirubin levels .; CNS: dizziness, sleep disturbance, headache .; On the part of the respiratory system: rarely - respiratory disorders, cough .; Allergic reactions: rarely - angioedema (including swelling of the face, lips, pharynx and / or tongue), urticaria .; Other: myalgia, edema, hyperkalemia (potassium in the blood of more than 5.5 mEq / l); rarely - tachycardia .; The drug is usually well tolerated.
Overdose
Symptoms: arterial hypotension, tachycardia .; Treatment: if necessary, conduct symptomatic therapy. Hemodialysis is not effective.
Interaction with other drugs
Co-administration with potassium-sparing diuretics, potassium preparations or potassium-containing salt substitutes can lead to hyperkalemia .; With simultaneous use of losartan with other antihypertensive drugs, there is a mutual strengthening of the hypotensive action .; Simultaneous use with NSAIDs (especially with indomethacin) may cause a weakening of the hypotensive effect of losartan .; The combination of losartan with diuretics can cause a drop in blood pressure.
special instructions
In patients with dehydration (for example, with high-dose diuretic therapy), symptomatic arterial hypotension may occur at the beginning of treatment with Presartan. It is necessary to carry out the correction of water and electrolyte balance before the appointment of Presartan or to begin treatment with a low dose .; Pharmacological data indicate that the concentration of losartan in the blood plasma of patients with cirrhosis of the liver increases significantly, so patients with a history of liver disease should be prescribed a low-dose drug. Some drugs that affect the system kinin-angiotensin, can increase the level of urea in the blood and serum creatinine in patients with impaired renal function.