Ribavirin capsules 200mg 30 pcs
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Description
Ribavirin - antiviral agent
Active ingredients
Ribavirin
Release form
Pills
Composition
ribavirin
Pharmacological effect
Antiviral agent. It quickly enters cells and acts inside cells infected with a virus. Intracellular ribavirin is easily phosphorylated by adenosine kinase to mono-, di-, and triphosphate metabolites. Ribavirin triphosphate is a strong competitive inhibitor of inosine monophosphate dehydrogenase, influenza virus RNA polymerase and guanylyl transferase messenger RNA, the latter is manifested by the inhibition of the messenger RNA coating process. These diverse effects lead to a significant reduction in the amount of intracellular guanosine triphosphate, as well as suppression of the synthesis of viral RNA and protein. Ribavirin inhibits the replication of new virions, which reduces viral load, selectively inhibits the synthesis of viral RNA without suppressing RNA synthesis in normally functioning cells. The most active against DNA viruses are the respiratory syncytial virus, Herpes simplex virus types 1 and 2, adenoviruses, CMV, smallpox group viruses, Marek's disease. RNA viruses - influenza A, B viruses, paramyxoviruses (parainfluenza, mumps, afflicted to infants), reus viruses, arenaviruses (Lassa fever virus, Bolivian hemorrhagic fever), bunyaviruses (Rift virus, Rift virus, and in and out and in and out and in and in; (hemorrhagic fever virus with renal or pulmonary syndrome) paramyxoviruses, oncogenic RNA viruses. When treating hemorrhagic fever with renal syndrome, reduces the severity of the disease, reduces the duration of symptoms (l iradochki, oliguria, pain in the lumbar region, abdomen, headache), improves the laboratory performance of kidney function, reduces the risk of hemorrhagic complications and the adverse outcome of the disease. DNA viruses are not sensitive to varicella zoster, pseudo rabies virus, cowpox virus. RNA viruses - enteroviruses, rhinoviruses, encephalitis virus of the Semliki forest.
Indications
For oral administration: treatment of chronic hepatitis C in adults (in combination with interferon alfa-2b or peginterferon alfa-2b). Parenteral: hemorrhagic fever with renal syndrome. Externally as monotherapy or in combination with other dosage forms of ribavirin for oral administration and parenteral use: infections of the skin and mucous membranes caused by viruses Herpes simplex type 1 and 2,various localization, incl. in the genital area. herpes zoster (as part of complex therapy).
Contraindications
There are CONTRAINDICATIONS. BEFORE USE IT IS REQUIRED TO READ THE INSTRUCTIONS
Precautionary measures
Application for violations of liver function. Contraindicated in severe liver failure, decompensated liver cirrhosis, autoimmune hepatitis. Use in renal dysfunction. Contraindicated in renal insufficiency (CC less than 50 ml / min). Use in childrenContraindicated in children and adolescents under 18 years of age.
Use during pregnancy and lactation
Ribavirin is contraindicated for use during pregnancy and lactation (breastfeeding).
Dosage and administration
Individual, depending on the evidence, age, regimen of application, dosage form.
Side effects
On the part of the central nervous system and peripheral nervous system: headache, dizziness, weakness, malaise, insomnia, asthenia, depression, irritability, anxiety, emotional lability, nervousness, agitation, aggressive behavior, confused consciousness. rarely - suicidal tendency, smooth muscle tone, tremor, paresthesia, hyperesthesia, hypoesthesia, syncope. From the cardiovascular system: decrease or increase in blood pressure, brady or tachycardia, heartbeat, cardiac arrest. From the side of hematopoietic organs: hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia. extremely rarely - aplastic anemia. On the part of the respiratory system: dyspnea, cough, pharyngitis, shortness of breath, bronchitis, otitis media, sinusitis, rhinitis. On the part of the digestive system: dry mouth, decreased appetite, nausea, vomiting, diarrhea, abdominal pain, constipation , taste perversion, pancreatitis, flatulence, stomatitis, glossitis, bleeding from the gums, hyperbilirubinemia. For the senses: damage to the lacrimal gland, conjunctivitis, blurred vision, impaired / hearing loss, tinnitus. For the musculoskeletal system: arthralgia, mialgiya.So sideways s urogenital system: hot flushes, loss of libido, dysmenorrhea, amenorrhea, menorrhagia, prostatit.Allergicheskie reactions: skin rash, erythema, urticaria, hyperthermia, angioedema, bronchoconstriction, anaphylaxis, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.with a / in the introduction - chills. Local reactions: pain at the injection site. Others: hair loss, alopecia, disruption of hair structure, dry skin, hypothyroidism, chest pain, thirst, fungal infection, viral infection (including herpes), flu-like syndrome, sweating, lymphadenopathy. Medical professionals performing inhalation may have headache, itching, eye flushing, or eyelid swelling.
Interaction with other drugs
The possibility of a medicinal or other type of interaction with ribavirin can last up to two months (5 periods of T1 / 2 ribavirin) after discontinuing its use due to delayed elimination. When used concurrently with interferons, therapeutic efficacy is increased. zidovudine.
special instructions
To apply only in the conditions of a hospital with specialized resuscitation department. The use of ribavirin in patients who require mechanical ventilation is possible only by specialists with experience in resuscitation. Use with caution in women of reproductive age (pregnancy is undesirable), in patients with decompensated diabetes mellitus (with bouts of ketoacidosis), in COPD, pulmonary embolism , chronic heart failure, in diseases of the thyroid gland (including with thyrotoxicosis), for disorders of blood coagulation, with thrombophlebitis, myelodepression, heme globinopathy (including for thalassemia, sickle cell anemia), depression, suicidal tendencies (including history), concomitant HIV infection (against the background of highly active antiretroviral therapy - the risk of lactic acidosis) in patients elderly. Medical personnel using ribavirin should take into account its teratogenicity.
Storage conditions
At room temperature. Keep out of the reach of children