Strepsils Intensive lozenges for honey and lemon 24 pieces
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Active ingredients
Flurbiprofen
Release form
Pills
Composition
Flurbiprofen 8.75 mg Auxiliary substances: macrogol 300 - 5.47 mg, sodium hydroxide - 2.19 mg, lemon flavor (502904A) - 3.6 mg, levomenthol - 2 mg, honey - 50.4 mg, liquid sucrose - 1407 mg, dextrose - 1069 mg.
Pharmacological effect
NSAIDs for local use in ENT practice and dentistry. The mechanism of action of flurbiprofen is associated with inhibition of the enzyme COX-1 and COX-2, followed by inhibition of the synthesis of prostaglandins - pain mediators. It has anti-inflammatory and analgesic effect. The therapeutic effect of the drug develops 30 minutes after the beginning of resorption of the tablet in the mouth and lasts for 2-3 hours.
Pharmacokinetics
Absorption and distributionThe degree of absorption is high. Cmax in the blood plasma is reached in 30-40 minutes. Binding to plasma proteins is more than 99%. Metabolism and excretion Basically metabolized by hydroxylation. Excreted in the urine. T1 / 2 is 3-6 hours.
Indications
- infectious and inflammatory diseases of the oral cavity and pharynx (as a symptomatic remedy for pain relief).
Contraindications
- peptic ulcer of the stomach (in the acute phase); - bronchial asthma and rhinitis while taking acetylsalicylic acid or other NSAIDs; - deficiency of glucose-6-phosphate dehydrogenase; - children under 12 years old; - pregnancy; - lactation period; components of the drug. The drug should be used with caution in hyperbilirubinemia (including Gilbert, Dubin-Johnson and Rotor syndrome), chronic heart failure, edema, arterial hypertension, hemophilia, decreased blood clotting, peptic ulcer stomach or duodenum (in remission, disease), renal and / or hepatic impairment, inhibition of bone marrow hematopoiesis, hearing loss, vestibular pathology apparata.Primenenie drug in elderly patients is possible only after consultation with your doctor.
Precautionary measures
During treatment, psoriasis may worsen. During pheochromocytoma, propranolol can only be used after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. during anesthesia, you must stop taking propranolol or find a remedy for anesthesia with minimal negative inotropic effects.The impact on the ability to drive vehicles and control mechanisms of patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient.
Use during pregnancy and lactation
The use of Strepfen during pregnancy is contraindicated. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.
Dosage and administration
The drug is used topically. Tablets dissolve in the mouth until dissolved. When resorption, you should move the tablet throughout the oral cavity, in order to avoid damage to the mucous membrane at the site of resorption. Adults and children over 12 years old are advised to take 1 tab. as required. It is not necessary to use more than 5 tab. within 24 hours. You should not take the drug for more than 3 days.
Side effects
Adverse reactions regarding the use of the drug Strepsils; Intensive, associated mainly with the distortion of taste perceptions and elements of paresthesia (burning, stinging or tingling). Possible ulceration of the oral mucosa. Undesirable side effects typical of NSAIDs can be observed when taking the drug orally at a dose of 50-100 mg 2-3 times / day (12-30 pills of Strepsils; Intensive per day). digestive system: dyspepsia (nausea, vomiting, heartburn, diarrhea), NSAID-gastropathy, abdominal pain, impaired liver function; with long-term use in high doses - ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival and hemorrhoidal). From the cardiovascular system: increased blood pressure, tachycardia, heart failure. , aplastic), agranulocytosis, leukopenia, thrombocytopenia. On the nervous system: headache, dizziness, drowsiness or insomnia, depression, amnesia, tremor, agitation; rarely - ataxia, paresthesia, impaired consciousness. From the urinary system: tubulointerstitial nephritis, edematous syndrome, renal dysfunction , tinnitus, increased sweating.
Overdose
Symptoms: when taking 1 g - drowsiness; more than 1.5 g - excitement; 2.5-4 g - nausea, headache, dizziness, epigastric pain, diplopia, miosis, hypotonia; more than 4 g - depression of consciousness up to coma. Treatment: the drug should be stopped; if necessary, conduct symptomatic therapy.
Interaction with other drugs
Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of flurbiprofen. Strepsils; Intensive reduces the effectiveness of uricosuric drugs. With simultaneous use of Strepsils; Intensive enhances the action of anticoagulants (increases the risk of bleeding), antiplatelet agents, fibrinolytics. Strepsils; Intensive enhances the side effects of mineral and glucocorticosteroids, estrogens. Strepsils; Intensive reduces the effectiveness of antihypertensives and diuretics. With simultaneous use of Strepsils; Intensive enhances the hypoglycemic effect of sulfonylurea derivatives. Strepsils; Intensive increases in blood lithium and methotrexate concentration.
special instructions
In the case of a combination of pain in the throat with a significant increase in body temperature, the drug can only be recommended by a doctor. If it is necessary to determine the 17-keto steroids, the drug should be canceled 48 hours before the study. Patients with diabetes should take into account that 1 tab. The drug contains about 2.5 grams of sugar. The patient should be warned that while maintaining a high temperature, the appearance of a headache or other undesirable effects, you should consult a doctor. Do not exceed the dose specified in the instructions.