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Active ingredients
Dicycloverine + Paracetamol
Release form
Pills
Composition
Paracetamol 500 mg dicycloverine hydrochloride 20 mg
Pharmacological effect
Combined anesthetic. The mechanism of action of Trigan-D is associated with the anticholinergic activity of the components of the drug. The analgesic effect is manifested in smooth muscle spasms. Dicyclomine hydrochloride is a tertiary amine with a weak non-selective M-anticholinergic and myotrophasmolytic action. Shows antispasmodic, antimuscarinic effect (relaxes smooth muscle elements of the walls of blood vessels and the digestive tract). Does not have atropine effects. Especially effective in diseases of the digestive system, which are associated with spasm of the smooth muscle membrane of the intestinal wall (for example, irritable bowel syndrome). Paracetamol is a nonsteroidal anti-inflammatory agent. It acts in synergism with dicyclomine hydrochloride, increases its effectiveness and accelerates its analgesic effect. Dicyclomine hydrochloride after oral administration is rapidly absorbed, cumulated in sufficient amount in the blood plasma after 1-1.5 hours. The half-life is 30-70 minutes. Excreted by the kidneys - approximately 79.5%. Paracetamol is completely and rapidly absorbed from the digestive tube. The maximum concentration is recorded after oral administration after 30 minutes. The analgesic effect begins already after 0.5 hours, and after 2 hours there is a peak analgesic effect.
Indications
Symptomatic treatment of pain in the abdomen: · Colic (kidney, liver, intestinal). · Irritable bowel syndrome with the presence of a spastic contraction of the intestinal smooth muscle. · Dysmenorrhea.
Contraindications
· Obstructive diseases of the urinary system, gastrointestinal tract and hepatic tract. · In case of acute bleeding in case of instability of the cardiovascular system. · Reflux esophagitis. · Myasthenia gravis. · Glaucoma. · Severe ulcerative colitis. · Marked impairment of hepatic and (or) renal functions. · Decompensated cardiovascular failure. · Prostatic hypertrophy. · Hypersensitivity to paracetamol and any other of the components Trigan-D. · Diseases of the blood system. · collapse . · Deficiency of glucose-6-phosphate dehydrogenase. · Age up to 12 years.
Use during pregnancy and lactation
Contraindicated for pregnant women.If the drug is prescribed to a nursing woman, breastfeeding for the period of taking the drug is temporarily stopped.
Dosage and administration
The recommended scheme of use in adults and adolescents from 12 years: 1-2 pills 2-4 p / day. Take 15 minutes before meals. The maximum single dose - 2 pills. The maximum daily dose is 4 pills. In acute pain syndrome, it is prescribed parenterally (intramuscularly) in a dose of 2 ml (20 mg dicyclamine) 4 p / day. The course of treatment is not more than 5 days.
Side effects
On the part of the digestive tract: difficulty in swallowing and talking, thirst, vomiting, decreased mobility and tone of the gastrointestinal tract, dry mouth, constipation. Since the cardiovascular system: tachycardia, arrhythmia, short-term bradycardia. From the nervous system: dizziness, staggering, drowsiness. On the part of the eyes: increased intraocular pressure, photophobia, pupil dilation with accommodation loss. Others: urinary incontinence, dryness and redness of the skin, allergic reactions, blood formation depression.
special instructions
On the part of the digestive tract: difficulty in swallowing and talking, thirst, vomiting, decreased mobility and tone of the gastrointestinal tract, dry mouth, constipation. Since the cardiovascular system: tachycardia, arrhythmia, short-term bradycardia. From the nervous system: dizziness, staggering, drowsiness. On the part of the eyes: increased intraocular pressure, photophobia, pupil dilation with accommodation loss. Others: urinary incontinence, dryness and redness of the skin, allergic reactions, blood formation depression.