Amoxicillin Sandoz film-coated pills 1g N12
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Amoxicillin
Release form
Pills
Composition
1 tab. Amoxicillin 1000 mg Amoxicillin trihydrate 1074 mg ,. Excipients: meglumin - 9.375 mg, glycofurfural - 150 mg, poloxamer 188 - 75 mg, sodium chloride - 4.5 mg, glycine - 7.5 mg, sodium hydroxide - 0.228 mg, water d / i - 1279.482 mg.
Pharmacological effect
Amoxicillin is an aminobenzyl penicillin, which has a bactericidal effect as a result of inhibiting the synthesis of bacterial cell walls. MIC thresholds vary for different sensitive organisms. Enterobacteriaceae are considered sensitive when inhibited by amoxicillin at a concentration of & # 8804. 8 mkg / ml amoxicillin and resistant at concentration & # 8805. 32 μg / ml. In accordance with the recommendations of NCCLS, when using the NCCLS-indicated methods, M. catarrhalis (& # 946.-Lactamase negative) and H. influenzae (& # 946.-Lactamase negative) are regarded as sensitive at concentrations & # 8804. 1 mkg / ml and resistant at & # 8805. 4 mcg / ml. Str.pneumoniae are considered sensitive with MIC & # 8804. 2 mkg / ml and resistant at & # 8805. 8 mcg / ml. The prevalence of resistant strains varies geographically, so it is desirable to focus on local information on resistance, especially in the treatment of severe infections. At this level of prevalence of resistant strains, at which the feasibility of using the drug becomes questionable, at least in the treatment of some infections, it is better to seek help from a specialist. hydrolyzing aminopenicillins, changes in penicillin-binding proteins, impaired permeability to the drug, or thanks to the functioning of special pump pumps, I pump out their preparation from the cells. In one microorganism, several mechanisms of resistance can be simultaneously present, which explains the existence of variable and unpredictable cross-resistance to other beta-lactams and antibacterial drugs from other groups.
Indications
It is indicated for oral therapy of the following bacterial infections caused by amoxicillin-sensitive gram-positive and gram-negative pathogens: - infections of the upper respiratory tract, including infections of the ear, nose and throat: acute otitis media, acute sinusitis, and bacterial pharyngitis.- lower respiratory tract infections: exacerbation of chronic bronchitis, community-acquired pneumonia. - infections of the lower urinary tract: cystitis. - infections of the gastrointestinal tract: bacterial enteritis. Combination therapy may be required for infections caused by anaerobic microorganisms. - endocarditis: prevention of endocarditis in patients at risk for the development of endocarditis - for example, during dental procedures.
Contraindications
- hypersensitivity to penicillin - it is also necessary to consider the possibility of cross-allergy with other beta-lactam antibiotics, such as cephalosporins, carbopenems. With care: - Ospamox should be used with caution in patients with allergic diathesis and asthma. - in patients with renal failure, amoxicillin elimination may be delayed, which, depending on the degree of insufficiency, may require a decrease in the daily dose of the drug. - with caution should be used in children, premature babies and newborns: it is necessary to monitor the function of the kidneys, liver and hematological parameters. - Ospamox should be used with caution in patients with viral infections, acute lymphoblastic leukemia and infectious mononucleosis (due to an increased risk of erythematous rash on the skin).
Use during pregnancy and lactation
The use of the drug during pregnancy is possible only in the case when the intended benefits to the mother outweigh the potential risk to the fetus. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.
Dosage and administration
Inside Infection Therapy: As a rule, therapy is recommended to continue for 2–3 days after the symptoms disappear. In the case of infections caused by #.-Hemolytic streptococcus, complete eradication of the pathogen requires therapy for at least 10 days. Parenteral therapy is indicated when oral inability is impossible and in the treatment of severe infections. Adult dosages (including elderly patients): Standard dose: The usual dose ranges from 750 mg to 3 g of amoxicillin per day in divided doses. In some cases, it is recommended to limit the dose of 1500 mg per day in several doses.Short course of therapy: Uncomplicated urinary tract infections: two doses of the drug, 3 g per injection, with an interval between doses of 10 to 12 hours. Pediatric dosages (up to 12 years) The daily dose for children is 25-50 mg / kg / day in several doses. (maximum 60 mg / kg / day) depending on the indication and the severity of the disease. Children weighing more than 40 kg should receive an adult dosage. Dosing for renal failure: In patients with severe renal insufficiency, the dose should be reduced. With renal clearance of less than 30 ml / min, an increase in the interval between doses or a decrease in subsequent doses is recommended. In case of renal insufficiency, short courses of therapy are contraindicated. 3 g. Adults (including elderly patients): Creatinine clearance ml / min. Dose Interval between injections> 30 Dose change is not required 10-30 500 mg 12 h less than 10 500 mg 24 h With hemodialysis: 500 mg should be entered after the procedure. Impaired renal function in children weighing less than 40 kg: Creatinine clearance ml / min Dose Interval between doses> 30 Dose changes are not required 10-30 15 mg / kg 12 h 10 15 mg / kg 24 h Prevention of endocarditis For the prevention of endocarditis in patients not under general anesthesia, 3 g of amoxicillin should be administered 1 hour before the operation and, if necessary, another 3 g after 6 hours. Children are recommended to take amoxicillin 50 mg / kg. For more detailed information and a description of the categories of patients at risk for endocarditis, refer to the local official guidelines.
Side effects
Side effects are classified as follows: Often: 10%, or less often, but more often 1% Infrequently: 1%, or less often, but more often 0.1% Rarely. 0.1% or less, but more often 0.01% Very rare, including isolated cases: 0.01% or less. Infections and infections. Infrequently. Prolonged and repeated use of a drug can lead to the development of superinfection and colonization of resistant microorganisms or fungi, for example, oral and vaginal candidiasis. Blood and lymphatic system disorders Rarely Eosinophilia and hemolytic anemia. Very rarely isolated cases of leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia, myelosuppression, agranulocytosis, lengthening of bleeding time and prothrombin time have been reported. All changes were reversible upon cessation of therapy. Immune system disorders Rarely Laryngeal edema, serum sickness, allergic vasculitis, anaphylaxis and anaphylactic shock in rare cases.Neurological disorders Rarely Reactions from the CNS are rare and include hyperkinesis, dizziness and convulsions. Seizures may occur in patients with renal insufficiency or in patients receiving high doses of the drug. Gastrointestinal disorders Often Feeling of discomfort, nausea, loss of appetite, vomiting, flatulence, liquefied stools, diarrhea, enanthema (especially on the oral mucosa), dry mouth, a violation of taste perception. As a rule, these effects are characterized by mild severity and often disappear as the therapy continues or very quickly after it is discontinued. To reduce the frequency of these complications by taking amoxicillin with food. With the development of severe persistent diarrhea, it is necessary to consider the possibility of a very rare complication, pseudomembranous colitis. The appointment of drugs that suppress motility is contraindicated. Very rarely The appearance of black coloring language. Disorders of the liver and biliary system: Infrequently Transient moderate increase in liver enzymes. Rare cases of hepatitis and cholestatic jaundice. Violations of the skin and subcutaneous fat: Often Skin reactions in the form of exanthema, itching, urticaria. a typical core-like exanthema appears on days 5-11 from the start of therapy. The immediate development of urticaria is indicative of an allergic reaction to amoxicillin and requires discontinuation of therapy. Rare (see also section 4.4) Angioedema (angioedema), exudative erythema multiforme, acute generalized pustular eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous and exfoliative dermatitis. Renal impairment Rarely In rare cases, acute interstitial nephritis. General disorders Rarely In rare cases, the development of drug fever.
special instructions
Side effects are classified as follows: Often: 10%, or less often, but more often 1% Infrequently: 1%, or less often, but more often 0.1% Rarely. 0.1% or less, but more often 0.01% Very rare, including isolated cases: 0.01% or less. Infections and infections. Infrequently. Prolonged and repeated use of a drug can lead to the development of superinfection and colonization of resistant microorganisms or fungi, for example, oral and vaginal candidiasis. Blood and lymphatic system disorders Rarely Eosinophilia and hemolytic anemia.Very rarely isolated cases of leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia, myelosuppression, agranulocytosis, lengthening of bleeding time and prothrombin time have been reported. All changes were reversible upon cessation of therapy. Immune system disorders Rarely Laryngeal edema, serum sickness, allergic vasculitis, anaphylaxis and anaphylactic shock in rare cases. Neurological disorders Rarely Reactions from the CNS are rare and include hyperkinesis, dizziness and convulsions. Seizures may occur in patients with renal insufficiency or in patients receiving high doses of the drug. Gastrointestinal disorders Often Feeling of discomfort, nausea, loss of appetite, vomiting, flatulence, liquefied stools, diarrhea, enanthema (especially on the oral mucosa), dry mouth, a violation of taste perception. As a rule, these effects are characterized by mild severity and often disappear as the therapy continues or very quickly after it is discontinued. To reduce the frequency of these complications by taking amoxicillin with food. With the development of severe persistent diarrhea, it is necessary to consider the possibility of a very rare complication, pseudomembranous colitis. The appointment of drugs that suppress motility is contraindicated. Very rarely The appearance of black coloring language. Disorders of the liver and biliary system: Infrequently Transient moderate increase in liver enzymes. Rare cases of hepatitis and cholestatic jaundice. Violations of the skin and subcutaneous fat: Often Skin reactions in the form of exanthema, itching, urticaria. a typical core-like exanthema appears on days 5-11 from the start of therapy. The immediate development of urticaria is indicative of an allergic reaction to amoxicillin and requires discontinuation of therapy. Rare (see also section 4.4) Angioedema (angioedema), exudative erythema multiforme, acute generalized pustular eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous and exfoliative dermatitis. Renal impairment Rarely In rare cases, acute interstitial nephritis.General disorders Rarely In rare cases, the development of drug fever.