Bitsillin-3 powder for preparation of suspension 600000ed
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Active ingredients
Benzatine benzylpenicillin
Release form
Powder
Composition
1 bottle of powder contains: Active substances: Benzathine benzylpenicillin 200,000 IU, benzylpenicillin sodium salt 200000 IU, benzylpenicillin novocaine salt 200000 IU
Pharmacological effect
Combined antibacterial drug of the penicillin group of prolonged action, collapsing penicillinase. The basis of the mechanism of action is a violation of the synthesis of peptidoglycan - the mucopeptide of the cell wall, which leads to inhibition of the synthesis of the cell wall of the microorganism, suppressing the growth and reproduction of bacteria. Active against gram-positive bacteria: Staphylococcus spp. (not forming penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Actinomyces Israel. The drug is also active against Treponema spp., Anaerobic spore-forming sticks, leishmania. Staphylococcus spp. Is resistant to the drug, producing penicillinase.
Pharmacokinetics
Absorption: With a single injection is stored in the average therapeutic concentration for 6-7 days. Cmax in plasma is reached 12-24 hours after administration. After administration of Bicillin-3 at a dose of 2.4 million. ED, the serum concentration on day 14 is 0.12 mcg / ml; after administration of Bicillin-3 at a dose of 1.2 million. EDU, the serum concentration on day 21 is 0.06 mcg / ml. Distribution and metabolism: After i / m administration, it is slowly hydrolyzed to release benzylpenicillin. To a small extent undergoes biotransformation. Binding to plasma proteins - 40-60%. Passes through the placental barrier, penetrates into breast milk. Well distributed in liquids, while the distribution in the tissues is low. Excretion: Excreted mainly by the kidneys.
Indications
Treatment of infectious diseases caused by pathogens that are sensitive to penicillin (especially in cases when it is necessary to create a long-term therapeutic concentration in the blood) B. Prevention of rheumatism. Leishmaniasis.
Contraindications
Hypersensitivity to penicillins and procaine (Novocain). Bronchial asthma. Hay fever. Other allergic diseases.
Precautionary measures
On the part of the digestive system: stomatitis, glossitis.On the part of the blood coagulation system: anemia, thrombocytopenia, leukopenia, hypocoagulation.
Use during pregnancy and lactation
Data on the use of the drug Bicillin-3 during pregnancy and lactation (breastfeeding) are not provided.
Dosage and administration
Bicillin-3 is injected deep into the upper outer quadrant of the buttocks in a dose of not more than 1.2 million IU. If necessary, 2 injections are made into different buttocks. Repeated injections carried out on 4 days after the previous injection. The drug in a dose of 600 000 IU is administered 1 time in 6 days. In the treatment of primary and secondary syphilis, a single dose of the drug is 1.8 mln. The course of treatment is 7 injections. The first injection is carried out at a dose of 300 000 IU, the second injection - after 1 day in a full dose (1.8 million U). Subsequent injections are carried out 2 times a week. In the treatment of secondary recurrent and latent early syphilis, a dose of 300,000 IU is used for the first injection, and 1.8 million IU for subsequent injections. Injections are carried out 2 times a week. The course of treatment is 14 injections. Forbidden to / in the introduction of the drug.
Side effects
Allergic reactions urticaria, angioedema, erythema multiforme, anaphylactic shock, arthralgia, fever, exfoliative edema. On the part of the digestive system, stomatitis, glossitis.
Overdose
Currently, no cases of overdose of Bicillin-3 have been reported.
Interaction with other drugs
With simultaneous use with bactericidal antibiotics (including cephalosporins, cycloserine, vancomycin, rifampicin, aminoglycosides), synergism of action is noted; with bacteriostatic antibiotics (including macrolides, chloramphenicol, linkosamides, tetracyclines) - antagonism. Bicillin-3 reduces the effectiveness of oral contraceptives and ethinyl estradiol (the risk of breakthrough bleeding). With the simultaneous use of Bicillin-3 with allopurinol increases the risk of allergic reactions. Pharmacokinetic interaction: With the simultaneous use of diuretics, allopurinol, phenylbutazone, NSAIDs reduce tubular secretion and increase the concentration of penicillin.
special instructions
With the development of allergic reactions should immediately discontinue treatment. With the development of anaphylactic shock, anti-shock therapy is indicated (administration of norepinephrine, GCS, mechanical ventilation is performed). Intravenous and endolyumbalny introduction is not allowed, since possible development of the syndrome Uanie (depression, anxiety, paresthesia, blurred vision). In the treatment of sexually transmitted diseases, in cases of suspected syphilis, before starting therapy and then for 4 months microscopic and serological studies are necessary. In connection with the possible development of fungal infections, it is advisable to prescribe antifungal drugs (nystatin, levorin), as well as ascorbic acid and vitamins of group B. It should be noted that the use of the drug in insufficient doses or early cessation of treatment leads to the appearance of resistant strains of pathogens.