Ketorolac-Verte pills 10mg N20,
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Description
Composition of Ketorolac tromethamine 10 mg Pharmacological action Ketorolac has a pronounced analgesic effect, also has anti-inflammatory and moderate antipyretic effect. The mechanism of action is associated with non-selective inhibition of the activity of the enzyme cyclooxygenase 1 and 2, mainly. in peripheral tissues, resulting in inhibition of the biosynthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation. Ketorolac is a racemic mixture of [-] S and [+] R enantiomers, while the analgesic effect is due to the [-] S form. The drug does not affect opioid receptors, does not inhibit respiration, does not cause drug dependence, does not have a sedative and anxiolytic effect. The strength of the analgesic effect is comparable with morphine, far superior to other NSAIDs. After ingestion, the onset of the analgesic effect is observed, respectively, after 1 h, the maximum effect is achieved after 1-2 h. A single dose of 10 mg, with repeated use is recommended to take 10 mg to 4 times / day, depending on the severity of pain. the maximum daily dose should not exceed 40 mg. When taken orally, the duration of the course should not exceed 5 days. Precautions During the period of treatment may worsen psoriasis. With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects. Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side Effects Often - more than 3%, less often - 1-3%, rarely - less than 1%.On the part of the digestive system: often (especially in elderly patients over 65 years old, with a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea. less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach. rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, melena, vomiting like “coffee grounds”, nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis. Urinary system disorders: rarely - acute renal failure, back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema renal genesis. From the senses: rarely - hearing loss, tinnitus, blurred vision (including blurred visual perception). On the part of the respiratory system: rarely: bronchospasm or dyspnea, rhinitis, laryngeal edema (shortness of breath, difficulty breathing). On the part of the central nervous system: often - headache, dizziness, drowsiness, rarely - aseptic meningitis (fever, severe headache, convulsions, stiff neck and / or back muscles), hyperactivity (change in mood, anxiety), hallucinations, depression, psychosis. Since the cardiovascular system: less often - increased blood pressure, rarely - pulmonary edema, fainting. From the side of blood-forming organs: rarely - anemia, eosiophilia, leukopenia. From the hemostatic system: rarely - bleeding from a postoperative wound, nosebleeds, rectal bleeding. On the part of the skin: less often - skin rash (including maculopapulla rash), purpura, rarely - exfoliative dermatitis (fever with or without chills, redness, hardening or peeling of the skin, swelling and / or tenderness of the tonsils), urticaria, Stevens syndrome- Johnson, Lyell Syndrome. Local reactions: less often - burning or pain at the injection site. Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (discoloration of skin, skin rash, urticaria, itchy skin, tachypnea or dyspnea, eyelid edema, periorbital edema, shortness of breath, difficulty breathing, chest heaviness, wheezing).Other: often - swelling (face, legs, ankles, fingers, feet, weight gain). less often - excessive sweating, rarely - swelling of the tongue, fever. Specific guidance The effect on platelet aggregation is terminated after 24-48 hours. Hypovolemia increases the risk of adverse reactions from the kidneys. If necessary, you can assign in combination with narcotic analgesics. Do not use simultaneously with paracetamol for more than 5 days. Patients with coagulation disorders are prescribed the drug only with constant monitoring of the number of platelets, especially important in the postoperative period, which requires careful monitoring of hemostasis. Impact on the ability to drive motor vehicles and control mechanisms Since a significant proportion of patients develop side effects from the central nervous system (drowsiness, dizziness, headache) when prescribing Ketorolaka-Verte, it is recommended to avoid performing work that requires increased attention and quick response (driving, with mechanisms, etc.). Use during pregnancy and breastfeeding Contraindicated in pregnancy, childbirth and lactation. Type: Medicinal product Amount in a package, pcs: 20 Shelf life: 24 months Scope of application: Anti-inflammatory and anesthetics Active ingredient: Ketorolac (Ketorolac) Route of administration: Oral Vacation schedule: Prescription Release form: Prescription Storage conditions: Dry, In protected from the sun room, Keep away from children Maximum allowable storage temperature, ° С: 25 Pharmacological group: M01AB Acetic acid derivatives Minimum age: 16 years
Active ingredients
Ketorolac
Release form
Pills
Composition
Ketorolaca tromethamine 10 mg
Pharmacological effect
Ketorolac has a pronounced analgesic effect, also has anti-inflammatory and moderate antipyretic effect. The mechanism of action is associated with non-selective inhibition of the activity of the enzyme cyclooxygenase 1 and 2, mainly. in peripheral tissues, resulting in inhibition of the biosynthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation. Ketorolac is a racemic mixture of [-] S and [+] R enantiomers, while the analgesic effect is due to the [-] S form.The drug does not affect opioid receptors, does not inhibit respiration, does not cause drug dependence, does not have a sedative and anxiolytic effect. The strength of the analgesic effect is comparable with morphine, far superior to other NSAIDs. After ingestion, the onset of the analgesic effect is noted, respectively, after 1 h, the maximum effect is achieved after 1-2 h.
Indications
- pain syndrome of medium and strong intensity of various genesis (including in the postoperative period, with cancer, etc.).
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs, "aspirin" asthma, bronchospasm, angioedema. - hypovolemia (regardless of the cause that caused it), dehydration. - erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, peptic ulcers. - hypocoagulation (including hemophilia). - hepatic and / or renal failure (plasma creatinine above 50 mg / l). - hemorrhagic stroke (confirmed or suspected). - hemorrhagic diathesis. - simultaneous reception with other NSAIDs. - high risk of developing or recurrent bleeding (including after surgery). - violation of blood formation. - pregnancy, childbirth and lactation. - children's age up to 16 years (efficiency and safety have not been established). - anesthesia before and during surgical operations (as there is a high risk of bleeding). - chronic pain. With care: bronchial asthma, cholecystitis, chronic heart failure, arterial hypertension, impaired renal function (plasma creatinine below 50 mg / l), cholestasis, active hepatitis, sepsis, systemic lupus erythematosus. old age (over 65). polyps of the nasal mucosa and nasopharynx.
Use during pregnancy and lactation
Contraindicated in pregnancy, childbirth and lactation.
Dosage and administration
Ketorolac-Verte is applied orally once or repeatedly, depending on the severity of the pain syndrome. A single dose of 10 mg, with repeated use is recommended to take 10 mg to 4 times / day, depending on the severity of pain. the maximum daily dose should not exceed 40 mg. When taken orally, the duration of the course should not exceed 5 days.
Side effects
Often - more than 3%, less often - 1-3%, rarely - less than 1%.On the part of the digestive system: often (especially in elderly patients over 65 years old, with a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea. less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach. rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, melena, vomiting like “coffee grounds”, nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis. Urinary system disorders: rarely - acute renal failure, back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema renal genesis. From the senses: rarely - hearing loss, tinnitus, blurred vision (including blurred visual perception). On the part of the respiratory system: rarely: bronchospasm or dyspnea, rhinitis, laryngeal edema (shortness of breath, difficulty breathing). On the part of the central nervous system: often - headache, dizziness, drowsiness, rarely - aseptic meningitis (fever, severe headache, convulsions, stiff neck and / or back muscles), hyperactivity (change in mood, anxiety), hallucinations, depression, psychosis. Since the cardiovascular system: less often - increased blood pressure, rarely - pulmonary edema, fainting. From the side of blood-forming organs: rarely - anemia, eosiophilia, leukopenia. From the hemostatic system: rarely - bleeding from a postoperative wound, nosebleeds, rectal bleeding. On the part of the skin: less often - skin rash (including maculopapulla rash), purpura, rarely - exfoliative dermatitis (fever with or without chills, redness, hardening or peeling of the skin, swelling and / or tenderness of the tonsils), urticaria, Stevens syndrome- Johnson, Lyell Syndrome. Local reactions: less often - burning or pain at the injection site. Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (discoloration of skin, skin rash, urticaria, itchy skin, tachypnea or dyspnea, eyelid edema, periorbital edema, shortness of breath, difficulty breathing, chest heaviness, wheezing).Other: often - swelling (face, legs, ankles, fingers, feet, weight gain). less often - excessive sweating, rarely - swelling of the tongue, fever.
special instructions
Often - more than 3%, less often - 1-3%, rarely - less than 1%. On the part of the digestive system: often (especially in elderly patients over 65 years old, with a history of erosive and ulcerative lesions of the gastrointestinal tract) - gastralgia, diarrhea. less often - stomatitis, flatulence, constipation, vomiting, feeling of fullness in the stomach. rarely - nausea, erosive and ulcerative lesions of the gastrointestinal tract (including perforation and / or bleeding - abdominal pain, spasm or burning in the epigastric region, melena, vomiting like “coffee grounds”, nausea, heartburn, etc.), cholestatic jaundice, hepatitis, hepatomegaly, acute pancreatitis. Urinary system disorders: rarely - acute renal failure, back pain with or without hematuria and / or azotemia, hemolytic uremic syndrome (hemolytic anemia, renal failure, thrombocytopenia, purpura), frequent urination, increased or decreased urine volume, nephritis, edema renal genesis. From the senses: rarely - hearing loss, tinnitus, blurred vision (including blurred visual perception). On the part of the respiratory system: rarely: bronchospasm or dyspnea, rhinitis, laryngeal edema (shortness of breath, difficulty breathing). On the part of the central nervous system: often - headache, dizziness, drowsiness, rarely - aseptic meningitis (fever, severe headache, convulsions, stiff neck and / or back muscles), hyperactivity (change in mood, anxiety), hallucinations, depression, psychosis. Since the cardiovascular system: less often - increased blood pressure, rarely - pulmonary edema, fainting. From the side of blood-forming organs: rarely - anemia, eosiophilia, leukopenia. From the hemostatic system: rarely - bleeding from a postoperative wound, nosebleeds, rectal bleeding. On the part of the skin: less often - skin rash (including maculopapulla rash), purpura, rarely - exfoliative dermatitis (fever with or without chills, redness, hardening or peeling of the skin, swelling and / or tenderness of the tonsils), urticaria, Stevens syndrome- Johnson, Lyell Syndrome. Local reactions: less often - burning or pain at the injection site.Allergic reactions: rarely - anaphylaxis or anaphylactoid reactions (discoloration of skin, skin rash, urticaria, itchy skin, tachypnea or dyspnea, eyelid edema, periorbital edema, shortness of breath, difficulty breathing, chest heaviness, wheezing). Other: often - swelling (face, legs, ankles, fingers, feet, weight gain). less often - excessive sweating, rarely - swelling of the tongue, fever.