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Active ingredients
Sodium heparin
Release form
Gel
Composition
100 g of gel contains: heparin sodium 100 000 ME. Excipients: methyl parahydroxybenzoate (nipagin or methyl paraben) - 0.2 g, ethanol (rectified ethyl alcohol) - 24 g, carbomer (carbopol) - 1 g, trolamine (triethanolamine) - 0.85 g, lavender essential oil - 0.1 g, purified water - 100 g
Pharmacological effect
Direct acting anticoagulant for external use from the group of medium molecular heparins. It has a moderate anti-inflammatory, anti-edema and antithrombotic effect. It blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of blood. Gradually released from the gel and penetrating through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots, reduces swelling of tissues.
Pharmacokinetics
A small amount of heparin is absorbed from the skin surface into the systemic circulation. Cmax of heparin in the blood is noted 8 hours after application. Excretion of heparin, mainly occurs by the kidneys, T1 / 2 -12 h.
Indications
Thrombophlebitis of the superficial veins; localized infiltrates and soft tissue swelling; injuries to tendons and joints; bruises of soft tissues and joints; subcutaneous hematomas (including hematomas with closed fractures of the upper and lower extremities and after phlebectomy in patients with varicose veins).
Contraindications
Ulcerative-necrotic changes in the skin at the sites of the intended application of the gel; traumatic violation of the integrity of the skin; reduced blood clotting; thrombocytopenia; children's age (no experience); hypersensitivity to the drug.
Precautionary measures
With caution should use the drug with increased vascular permeability.
Use during pregnancy and lactation
It is possible to use the drug during pregnancy and during breastfeeding if the intended benefit to the mother outweighs the potential risk to the fetus.
Dosage and administration
The drug is applied externally. The gel should be applied with a thin layer on the affected area at the rate of 3-5 cm of the gel on the skin area with a diameter of 3-5 cm and gently rub into the skin. Apply 1-3 times / day daily until inflammation disappears, on average from 3 up to 7 days. The possibility of a longer course of treatment is determined by the doctor.
Side effects
Possible: allergic reactions.
Overdose
Overdose is unlikely due to the low absorption of gel components.
Interaction with other drugs
Drug Lavenum; It should not be prescribed externally at the same time with NSAIDs, antibiotics of the tetracycline group, antihistamines. It is not recommended to mix the gel with other means for external use.
special instructions
It is not recommended to use Lavenum; when bleeding and in the presence of local purulent processes, as well as applied to open wounds, mucous membranes. The use of the gel is not recommended for thrombosis of deep veins. The effect on the ability to drive motor vehicles and control mechanismsNo data.