Lorista H coated pills 50mg + 12.5mg N30
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Active ingredients
Losartan + Hydrochlorothiazide
Release form
Pills
Composition
Potassium losartan 50 mg hydrochlorothiazide 12.5 mg adjuvants: pregelatinized starch — 34.92 mg, microcrystalline cellulose — 87.7 mg, lactose monohydrate — 63.13 mg, magnesium stearate — 1.75 mg. (e104) - 0.11 mg, titanium dioxide (e171) - 1.39 mg, talc - 0.5 mg.
Indications
- arterial hypertension (to patients for whom combination therapy is indicated); - reduction of the risk of cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy.
Contraindications
Anuria lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome; hypersensitivity to the drug components; hypersensitivity to sulfonamide derivatives. With caution: impairment of blood electrolyte balance (hyponatremia, hypochloraemic alkalosis, gi magnemia, hypokalemia), bilateral renal artery stenosis, arterial stenosis of the only functioning kidney, condition after kidney transplantation, hypercalcemia, hyperuricemia and / or gout, aggravated allergic history, bronchial asthma, systemic connective tissue diseases (including systemic lupus erythematosus) , simultaneous use of NSAIDs, including COX-2 inhibitors, diabetes mellitus, abnormal liver function, renal dysfunction (CC from 30-50 ml / min), hypovolemia (including while receiving diuretics in high doses), an acute attack of angle-closure glaucoma.
Precautionary measures
During treatment, psoriasis may worsen. During pheochromocytoma, propranolol can only be used after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. during anesthesia, you must stop taking propranolol or find a remedy for anesthesia with minimal negative inotropic effects.The impact on the ability to drive vehicles and control mechanisms of patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient.
Dosage and administration
I accept inside, irrespective of food intake. The preparation of Lorista H 100 can be combined with other antihypertensive drugs. Arterial hypertension The recommended dose of the drug Lorista H 100 - 1 tab. (100 mg / 12.5 mg) 1 time / day. As a rule, the drug is prescribed in the absence of an adequate therapeutic effect of Lorista H (50 mg / 12.5 mg). The maximum antihypertensive effect is achieved within 3 weeks of therapy. In elderly patients, in patients with impaired renal function (CC 30-50 ml / min ), including patients on dialysis, no initial dose adjustment is required. Reducing the risk of cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy. Initial and maintenance dose of losartan - 50 mg 1 time / day. Patients who have not managed to achieve the target level of blood pressure while using losartan at a dose of 50 mg / day require a selection of therapy by combining losartan with low doses of hydrochlorothiazide (12.5 mg). If necessary, it is possible to increase the dose of losartan to 100 mg in combination with hydrochlorothiazide at a dose of 12.5 mg / day. The recommended dose of Lorista H is 100-1 tab. (100 mg / 12.5 mg) 1 time / day. Maximum daily dose - 1 tab. drug Lorista H 100. In patients with impaired renal function dose adjustment is not required. Elderly patients dose adjustment is not required.
Side effects
Classification of the incidence of side effects (WHO): very often (≥1 / 10), often (from ≥1 / 100 to <1/10), infrequently (from ≥ 1/1000 to <1/100), rarely (from ≥ 1/10 000 to <1/1000), very rarely (from <1/10 000, including individual messages), the frequency is unknown (the frequency cannot be estimated based on the available data). From the immune system: rarely - anaphylactic reactions, angioedema (including swelling of the larynx and tongue, causing airway obstruction and / or swelling of the face, lips, pharynx), urticarial rash. On the side of the hemopoietic system: infrequently - anemia Genoha, ecchymosis, hemolysis, agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia,thrombocytopenia. From the nervous system: often - headache, dizziness, insomnia, fatigue; infrequently - migraine, anxiety, confusion, depression, sleep disturbances, memory impairment, drowsiness, nervousness, paresthesia, tremor, syncope. From the side of the cardiovascular system: often - orthostatic hypotension (dose-dependent), heartbeat, tachycardia; infrequently - AV block II degree, pain in the sternum, myocardial infarction, arrhythmias; rarely - vasculitis. Respiratory system: often - cough, infections of the upper respiratory tract, sinusitis, swelling of the nasal mucosa, nasal congestion; infrequently - pharyngitis, laryngitis, rhinitis, dyspnea, bronchitis, nasal bleeding. On the part of the digestive system: often - diarrhea, dyspepsia, nausea, vomiting, abdominal pain; rarely - hepatitis, abnormal liver function. From the urinary system: infrequently - urinary tract infections, frequent urination, nocturia, glycosuria. From the reproductive system: rarely - weakening of libido, reduced potency. From the sense organs: infrequently - blurred vision, feeling burning in the eyes, conjunctivitis. From the side of the skin: often - alopecia, dry skin, erythema, photosensitivity, increased sweating; infrequently - urticaria, pruritus. From the musculoskeletal system: often - myalgia, back pain; infrequently - arthralgia. Others: often - asthenia, weakness, peripheral edema; infrequently - anorexia, exacerbation of the course of gout. From the laboratory parameters: often - hyperkalemia, a slight decrease in the concentration of hemoglobin and hematocrit; infrequently - a moderate increase in the concentration of urea and creatinine in the blood plasma, hyperglycemia, hyperuricemia, disorders of the water-electrolyte balance; rarely, increased ALT activity; very rarely, increased ACT activity and bilirubin concentration.