Omnick Okas pills 400mcg 30 pcs
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Description
OMNIK OKAS - alpha1-blocker. It is a specific competitive blocker of postsynaptic α1-adrenergic receptors, especially α1A and α1D subtypes, which are in the smooth muscles of the prostate gland, bladder neck, prostatic urethra, and detrusor. Reduces the tone of the smooth muscles of the prostate gland and urethra, improving the flow of urine, reduces the phenomenon of instability of the bladder. This leads to a reduction in the symptoms of obstruction (emptying) and irritation (filling) associated with benign prostatic hyperplasia. The described effect on the symptoms of obstruction and irritation persists with prolonged use.
Active ingredients
Tamsulosin hydrochloride
Release form
Pills
Composition
tamsulosin hydrochloride 400 mcg. Auxiliary substances: macrogol 8000 - 40 mg, macrogol 7 000 000 - 200 mg, magnesium stearate - 1.2 mg.
Pharmacological effect
Α1-adrenoreceptor blocker. remedy for symptomatic treatment of benign prostatic hyperplasia. Selectively blocks postsynaptic α1A-adrenergic receptors of the smooth muscles of the prostate, bladder neck, prostatic urethra. As a result, the smooth muscle tone of these formations is reduced, urine flow is facilitated. At the same time, the symptoms of obstruction and irritation associated with benign prostatic hyperplasia are reduced. The therapeutic effect is manifested approximately 2 weeks after the start of treatment. The ability of α1B-adrenoreceptors of vascular smooth muscle is significantly less pronounced in tamsulosin, therefore, the effect on systemic blood pressure is insignificant.
Pharmacokinetics
After oral administration, tamsulosin is rapidly and almost completely absorbed from the gastrointestinal tract. After a single ingestion of 400 μg Cmax of the active substance in the plasma is achieved after 6 hours. Binding to plasma proteins is 99%. Vd is insignificant and amounts to 0.2 l / kg. Tamsulosin is slowly metabolized in the liver to form pharmacologically active metabolites that retain a high selectivity for α1A-adrenergic receptors. Most of the active substance is present in the blood unchanged. T1 / 2 of tamsulosin in a single dose is 10 hours, the terminal T1 / 2 is 22 hours.Excreted by the kidneys, 9% - unchanged.
Indications
Benign prostatic hyperplasia.
Contraindications
There are CONTRAINDICATIONS. BEFORE USE IT IS REQUIRED TO READ THE INSTRUCTIONS
Precautionary measures
Application for violations of the liver functionWith caution is used in patients with pronounced violations of the liver function.It is not necessary to change the dosing regimen for patients with impaired renal function. In patients with impaired renal function.
Dosage and administration
Inside - 400 mcg 1 time / day (after breakfast).
Side effects
On the part of the cardiovascular system: rarely - dizziness, orthostatic hypotension, feeling of heartbeat. On the side of the CNS: headache, asthenia are possible. On the part of the reproductive system: rarely - retrograde ejaculation.
Interaction with other drugs
With the simultaneous use of tamsulosin with cimetidine, there was a slight increase in the concentration of tamsulosin in the blood plasma, and with furosemide a decrease in the concentration. with other α1-adrenergic blockers, a pronounced increase in the hypotensive effect is possible. Diclofenac and indirect anticoagulants somewhat increase the rate of elimination of tamsulozin. Diazepam, propranolol, trichlormethiazide, chlormadinone, glitchfenac, anxparamol, Glbencamine, isopropylamine, Gidbencamine, isopropylamine, Gidbencamine, Gidbencamine, Gidbencamine, Gidbencamine, Gidbenkam, Gidbenkam. In turn, tamsulosin also does not alter the free fractions of diazepam, propranolol, trichloromethiazide, and chlormadinone. In in vitro, no interaction at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide, and finasteride was detected. , diuretics, levodopa, antidepressants, beta-blockers, slow calcium channel blockers, muscle relaxants, nitrates and ethanol can increase the severity of hypotensive effects KTA.
special instructions
It is used with caution in patients prone to hypotension, with marked impaired liver function. Before starting treatment with tamsulosin, the patient should be examined for other diseases that can cause the same symptoms as benign prostatic hyperplasia.Before treatment, and regularly during therapy, a digital rectal examination should be performed and, if required, the determination of a specific prostate antigen. In patients with impaired renal function, changes in the dosage regimen are not required. Impact on the ability to drive motor vehicles and control mechanisms. During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require an increased concentration of attention and quickness of psychomotor reactions.
Storage conditions
In a dry place. Keep out of the reach of children