Rigevidon 21 + 7 pills 84 pcs
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Description
The pills Rigevidon is an oral contraceptive, its use makes it possible to prevent unwanted pregnancy. This effect of the drug is realized by suppressing ovulation, increasing the viscosity of cervical mucus, and changing the structure of the endometrium. The ability to fertilize is fully restored in 1-3 cycles after the abolition of Rigevidon.
Active ingredients
Levonorgestrel + Ethinyl Estradiol
Release form
Pills
Composition
Ethinyl estradiol, levonorgestrel, colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate, Shell: sucrose, talc, calcium carbonate, titanium dioxide, copovidone, macrogol 6000, colloidal silicon dioxide, povidone, carmellose sodium.
Pharmacological effect
Combined monophasic oral hormonal contraceptive drug. When ingestion inhibits pituitary secretion of gonadotropic hormones. The contraceptive effect is associated with several mechanisms. As a gestagen component (progestin) contains a derivative of 19-nortestosterone - levonorgestrel, surpassing the activity of the corpus luteum hormone progesterone (and the synthetic analogue of the latter - pregnin), acts at the receptor level without prior metabolic transformations. Ethinyl estradiol is an estrogen component. Under the influence of levonorgestrel, a blockade of LH and FSH release from the hypothalamus occurs, suppression of pituitary gonadotropic hormone secretion by the pituitary gland, which leads to inhibition of maturation and release of an egg (ovulation) ready for fertilization. Contraceptive action is enhanced by ethinyl estradiol. Retains a high viscosity of the cervical mucus (makes it difficult for sperm to enter the uterus). Along with the contraceptive effect with regular use, it normalizes the menstrual cycle and helps prevent the development of a number of gynecological diseases, including neoplastic nature.
Pharmacokinetics
Ethinyl estradiol is rapidly and almost completely absorbed from the intestines. Metabolized in the liver and intestines. Ethinyl estradiol metabolites - water-soluble sulfate or glucuronide conjugates, enter the intestine with bile, where they are disintegrated by intestinal bacteria. Metabolized in the liver, T1 / 2 is 2-7 hours.Ethinyl estradiol is eliminated by the kidneys (40%) and through the intestines (60%). Levonorgestrel is rapidly absorbed (in less than 4 hours). When combined with the use of levonorgestrel with ethinyl estradiol, there is a relationship between dose and maximum plasma concentration. Most of the levonorgestrel binds to albumin and SHBG (sex hormone-binding globulin) in the blood. Metabolized in the liver. Levonorgestrel is excreted by the kidneys (60%) and through the intestines (40%).
Indications
Oral contraception, functional disorders of the menstrual cycle (including dysmenorrhea without an organic cause, dysfunctional metrorrhagia, premenstrual syndrome).
Contraindications
Severe liver disease, congenital hyperbilirubinemia, cholecystitis, the presence or history of severe cardiovascular and cerebrovascular diseases, thromboembolism and susceptibility to them, malignant tumors (primarily breast cancer or endometrium), liver tumors, family forms of lipidpideitis. arterial hypertension, endocrine diseases (including severe diabetes), sickle cell anemia, chronic hemolytic anemia, vaginal bleeding unknown th etiology, molar pregnancy, migraine, otosclerosis, pregnant women idiopathic jaundice in history, severe itching during pregnancy, herpes gestationis, age over 40 years, hypersensitivity to the drug.
Precautionary measures
With care: in diseases of the liver and gallbladder, epilepsy, depression, ulcerative colitis, uterine myoma, mastopathy, tuberculosis, kidney disease, diabetes, cardiovascular diseases, hypertension, impaired renal function, varicose veins, phlebitis, otosclerosis, multiple sclerosis, small chorea, intermittent porphyria, latent tetany, bronchial asthma, in adolescence (without regular ovulatory cycles).
Use during pregnancy and lactation
Contraindicated
Dosage and administration
Inside, without chewing and squeezing a small amount of liquid. To start contraception with Rigevidon, start from the 1st day of menstruation, taking 1 tablet daily for 21 days, at the same time of day.This is followed by a 7-day break, during which menstrual-like bleeding occurs. The next 21-day cycle of taking pills from a new package containing 21 pills should be started the next day after a 7-day break, i.e. on the 8th day, even if the bleeding has not stopped. Thus, the start of taking the drug from each new package falls on the same day of the week. The missed pill should be taken within the next 12 hours. If 36 hours have passed since taking the last pill, contraception is unreliable. In order to avoid intermenstrual bleeding, taking the drug should be continued from the already started packaging, with the exception of the missed pill. In case of missed pills, it is recommended to additionally use another, non-hormonal method of contraception (for example, barrier). For therapeutic purposes, the dose of the drug Rigevidon and the scheme of use are selected by the doctor in each case individually.
Side effects
Possible side effects of a transient nature that pass spontaneously: nausea, vomiting, headache, engorgement of the mammary glands, changes in body weight and libido, changes in mood, acyclic bleeding. During prolonged administration, chloasma, hearing loss, generalized itching, jaundice, can rarely occur convulsions of the gastrocnemius muscles, an increase in the frequency of epileptic seizures.
Interaction with other drugs
Reducing the contraceptive effect while taking it with barbiturates, some antiepileptic drugs (carbamazepine, phenytoin), sulfonamides, derivatives of pyrazolone. A similar effect when administered concomitantly with some antimicrobial agents (including ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines). If used simultaneously with anticoagulants derived from coumarin or indandion, it may require additional determination doses of anticoagulant. When using tricyclic antidepressants, maprotiline, beta-blockers may increase their bioavailability and toxicity.P and the use of oral hypoglycemic agents and insulin, it may be necessary to change them dozy.Pri combination with bromocriptine reduced effektivnost.Pri its combination with drugs with potential hepatotoxic effect, e.g., a drug dantrolene, amplification hepatotoxicity observedespecially in women over 35 years old.
special instructions
Smoking women who take hormonal contraceptives have an increased risk of developing cardiovascular diseases with serious consequences (myocardial infarction, stroke). The risk increases with age and depending on the number of cigarettes smoked (especially in women older than 35 years).