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Active ingredients
Isoconazole
Release form
Cream
Composition
Active substance: in 1 ml of oxymetazoline hydrochloride 500 mcg. Excipients: disodium edetate dihydrate - 300 mcg, sodium hydrogen phosphate - 975 mcg, sodium dihydrogen phosphate monohydrate - 5.525 mg, povidone K29-32 - 30 mg, benzalkonium chloride 17% - 1.471 mg, macrogol 1450 - 50 mg, benzyl alcohol - 2.5 mg, microcrystalline cellulose and carmellose sodium (Avicel RC-591) - 30 mg, lemon flavoring - 1.5 mg, purified water - qs to 1 ml.
Pharmacological effect
Isoconazole is an imidazole derivative. The active ingredient has a fungistatic effect, has antibacterial activity. Increased concentrations allow to achieve fungicidal activity. The action is realized by suppressing the synthesis of ergosterol and changing the composition of fungal cells that are incompatible with their life. Isoconazole disrupts the membrane structure of microbial cells. There is a sensitivity to isoconazole in yeast fungi, dermatophytes, yeast-like fungi, corynebacteria, streptococci, staphylococci. Antibacterial activity is realized by blocking the synthetic processes associated with the production of para-aminobenzoic acid. It is important for protein synthesis in the cells of bacteria. Thus, due to the cessation of protein synthesis, the life of bacteria is impaired and their death occurs. Due to the optimal ointment base, the active substance penetrates through the epidermis. A sufficient therapeutic concentration in the dermis is created already 60 minutes after the application of the cream. High antimycotic concentration of the active ingredient in the upper layers of the dermis lasts about 7 hours. Metabolizing isoconazole in the epidermis does not occur.
Pharmacokinetics
When applied to the skin, systemic absorption is negligible.
Indications
Fungal lesions of the skin, incl. secondarily infected: - mycoses of the feet and smooth skin (including localized in the folds of the skin and in the area of the external genital organs); - microsporia, trichophytosis, rubrofitia; - athlete's disease; - Candidomycosis; - Multicolored (scaly) lichen; - Erythrasma.
Contraindications
hypersensitivity to the drug.
Precautionary measures
Treatment by Travogenomedemy from 1 month to 2 years is carried out under the supervision of a doctor. Children from the age of 1 month Travogen applied 1 time / day in a thin layer on the affected skin and lightly rubbed. The course of treatment is usually 2-3 weeks, with the localization of mycoses in the folds - up to 4 weeks. A longer course of treatment is also possible. To prevent relapse, treatment should be continued for 2 weeks after resolution of clinical manifestations.
Use during pregnancy and lactation
Use of the drug during pregnancy is possible in cases where the potential benefit to the mother outweighs the risk to the fetus. It is not established whether isoconazole penetrates into breast milk, so the drug should not be applied to the mammary glands before feeding. If necessary, use the drug to decide on the termination of breastfeeding.
Dosage and administration
Outwardly, adults and children from the age of 1 month. Travogen is applied with a thin layer on the affected skin and lightly rubbed once a day. The course of treatment is usually 2-3 weeks., With the localization of mycoses in the folds - up to 4 weeks. A longer course of treatment is also possible. To prevent relapse, treatment should be continued for 2 weeks. after the resolution of clinical manifestations.
Side effects
Dermatological reactions: rarely - skin irritation (burning sensation and itching, erythema); extremely rare - skin allergic reactions. Travogen is generally well tolerated, even when applied to sensitive skin.
Overdose
To date, overdose reports have not been reported.
Interaction with other drugs
Not found.
special instructions
The drug is intended for external use only. If you have symptoms that indicate hypersensitivity or irritation, the drug should be discontinued. Avoid contact with eyes. In case of accidental contact with the drug in the eyes, rinse thoroughly with warm water. The patient must inform the doctor about the appearance of any undesirable effects during treatment with Travogen. If there is no effect, the patient should consult a doctor. Use in pediatrics Treatment with Travogen children from 1 month to 2 years old is carried out under the supervision of a doctor.