Trental coated pills prolonged 400mg N60
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Active ingredients
Pentoxifylline
Release form
Pills
Composition
Pentoxifylline active substance 400 mg; excipients: core: hypromellose 2200 - 0.12000 g, povidone 40 - 0.01650 g, talc - 0.01050 g, magnesium stearate - 0.00300 g; casing: sepifilm 752 white (hypromellose - 35.0% -45.0%. Microcrystalline cellulose - 27.0% -37.0%, macrogol stearate - 6.0% -10.0%. titanium dioxide - 18.0% - 22.0%) - 0.01500 g, dimethicone emulsion - 0.000075 g, macrogol 6000 - 0.000175 g;
Pharmacological effect
Vasodilator, improves microcirculation, normalizes the rheological properties of blood;
Pharmacokinetics
After oral administration, pentoxifylline is rapidly and almost completely absorbed. After almost complete absorption, pentoxifylline is metabolized. The absolute bioavailability of the original substance is (19 ± 13)%. The main active metabolite of 1- (5-hydroxyhexyl) -3,7-dimethylxanthine (metabolite-1) has a plasma concentration 2 times the initial concentration of pentoxifylline; T1 / 2 of pentoxifylline after oral administration is 1.6 hours; Pentoxifylline is completely metabolized, more than 90% is excreted through the kidneys in the form of unconjugated water-soluble metabolites. Excretion of metabolites is delayed in patients with impaired renal function. In patients with impaired T1 / 2 liver function, pentoxifylline is lengthened and absolute bioavailability increases. ;
Indications
Peripheral circulation disorders of atherosclerotic genesis (for example, intermittent claudication, diabetic angiopathy), trophic disorders (for example, trophic ulcer of the leg, gangrene); cerebral circulatory disorders (consequences of cerebral atherosclerosis, such as impaired concentration, dizziness, memory loss), ischemic and post-stroke conditions; circulatory disorders in the retina and choroid; otosclerosis, degenerative changes on the background of the pathology of the vessels of the inner ear and hearing loss .;
Contraindications
Hypersensitivity to pentoxifylline, other methylxanthines or to any of the components of the drug; massive bleeding, extensive hemorrhages in the retina, bleeding in the brain; acute myocardial infarction; pregnancy; breastfeeding period; children under the age of 18.; Ccaution: severe cardiac arrhythmias (risk of worsening arrhythmias); hypotension (risk of further lowering blood pressure); chronic heart failure; peptic ulcer and duodenal ulcer; impaired renal function (Cl creatinine below 30 ml / min) (risk of accumulation and an increased risk of side effects); severe abnormal liver function (risk of accumulation and increased risk of side effects); after recent surgery; increased tendency to bleeding, for example, as a result of the use of anticoagulants or in case of disturbances in the blood coagulation system (risk of more severe bleeding) .;
Use during pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding;
Dosage and administration
The dosage is set by the doctor in accordance with the individual characteristics of the patient.; Inside, swallowing whole, during or immediately after a meal, drinking plenty of water.; The usual dose - 1 tab. Trental 400 mg 2-3 times a day. The maximum daily dose is 1200 mg. In patients with impaired renal function (Cl creatinine <30 ml / min), the dosage can be reduced to 1-2 pills. per day. ;
Side effects
In cases where Trental is used in large doses, the following side effects may sometimes occur. From the nervous system: headache, dizziness, anxiety, sleep disturbances, convulsions. From the skin and subcutaneous fat: facial flushes, hot flushes to the face and upper chest, edema, increased nail brittleness; On the part of the digestive system: xerostomia, anorexia, intestinal atony. On the part of the cardiovascular system: tachycardia, arrhythmia, cardialgia, progression of the walls ardiya, lowering blood pressure. From the side of the hemostatic system and blood-forming organs: leukopenia, thrombocytopenia; pancytopenia, bleeding from skin vessels, mucous membranes, stomach, intestines, hypofibrinogenemia; On the part of the sense organs: visual disturbances, scotoma.; Allergic reactions: itching, skin hyperemia, urticaria, angioedema, anaphylactic shock. ; Very rarely, there are cases of aseptic meningitis, intrahepatic cholestasis and increased activity of "liver" transaminases, alkaline membrane.From the alimentary system: feeling of pressure and overflow in the stomach, nausea, vomiting, diarrhea;
Overdose
Symptoms: dizziness, urge to vomit, falling blood pressure, tachycardia, arrhythmia, redness of the skin, loss of consciousness, chills, areflexia, tonic-clonic seizures.; Treatment: symptomatic, special attention should be directed at maintaining blood pressure and respiratory function. Convulsive seizures are relieved by administering diazepam. When the first signs of an overdose appear (excessive sweating, nausea, cyanosis), the drug is immediately stopped. Provide a lower position of the head and upper torso. Monitor the free airway.
Interaction with other drugs
Pentoxifylline is able to increase the effect of drugs that reduce blood pressure (ACE inhibitors, nitrates) .; Pentoxifylline may increase the effect of drugs affecting the blood coagulation system (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins); Cimetidine increases the concentration plasma pentoxifylline (risk of side effects); co-administration with other xanthines can lead to excessive nervous excitement. Sugar-lowering effects of insulin or oral antidiabetic agents can It is enhanced when receiving pentoxifylline (increased risk of hypoglycaemia). Strict monitoring of such patients is necessary. In some patients, simultaneous administration of pentoxifylline and theophylline may lead to an increase in theophylline levels. This can lead to an increase or increase in side effects associated with theophylline;
special instructions
Treatment should be under the control of blood pressure.; In patients with diabetes who are taking hypoglycemic agents, the appointment of large doses can cause severe hypoglycemia (dose adjustment is required) .; When prescribed simultaneously with anticoagulants, it is necessary to carefully monitor blood coagulation parameters. who underwent surgery, requires systematic monitoring of hemoglobin and hematocrit.; The injected dose should be reduced in patients with low and unstable blood pressure.; In elderly people she may need to reduce the dose (increase bioavailability and decrease the rate of excretion); the safety and efficacy of pentoxifylline in children have not been studied enough