Upsarin UPSA effervescent pills 500 mg 16 pcs
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Active ingredients
Acetylsalicylic acid
Release form
Pills
Composition
Acetylsalicylic acid. ; Excipients: anhydrous citric acid, sodium anhydrous carbonate, sodium bicarbonate, sodium anhydrous citrate, aspartame, povidone, crospovidone, natural orange flavoring;
Pharmacological effect
Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs with painkillers, antipyretic and anti-inflammatory properties. Its mechanism of action is based on the irreversible inhibition of cyclooxygenase enzymes involved in the synthesis of prostaglandin. Acetylsalicylic acid also inhibits platelet aggregation by blocking platelet synthesis of A2 thromboxane;
Pharmacokinetics
Acetylsalicylic acid is rapidly absorbed by oral administration. Maximum plasma concentrations are reached in 15-40 minutes. Acetylsalicylic acid undergoes rapid hydrolysis to form the active metabolite of salicylic acid. Bioavailability depends on the dose and is 60% for a dose of less than 500 mg and 90% for doses over 1 g. Acetylsalicylic acid and salicylic acid are rapidly distributed to all tissues. Penetrate the placental barrier and enter the mother's milk. Salicylic acid is largely bound to plasma proteins (90%). The half-life of plasma is 15-20 minutes for acetylsalicylic acid and 2 to 4 hours for salicylic acid. Acetylsalicylic acid is largely metabolized in the liver, mainly excreted in the urine as salicylic acid and glucuronic conjugates;
Indications
Moderate or mild pain syndrome in adults of different origin: headache (including associated with alcohol withdrawal syndrome), toothache, migraine, neuralgia, chest root syndrome, muscle and joint pain, algomenorrhea; - increased body temperature with colds and other infectious and inflammatory diseases (in adults and children older than 15 years);
Contraindications
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, gastrointestinal bleeding; - severe liver dysfunction; - pronounced renal dysfunction; - "aspirin" asthma; - hemorrhagic diathesis (hemophilia, Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia,thrombocytopenic purpura); - stratifying aortic aneurysm; - portal hypertension; - vitamin K deficiency; - deficiency of glucose-6-phosphate dehydrogenase; - phenylketonuria; - I and III trimesters of pregnancy; - lactation period (breastfeeding); - children under the age of 15 years with acute respiratory diseases caused by viral infections, due to the risk of Reye’s syndrome (encephalopathy and acute fatty liver dystrophy with acute development of liver failure); - hypersensitivity to the drug; - hypersensitivity to other NSAIDs.; The drug should be used with caution in hyperuricemia, urate nephrolithiasis, gout, gastric ulcer and / or duodenal ulcer (in history), decompensated heart failure .;
Use during pregnancy and lactation
The drug is contraindicated in the I and III trimesters of pregnancy.; If necessary, use the drug during lactation, breastfeeding should be stopped;
Dosage and administration
To take the drug should dissolve the tablet / pills in a glass (200 ml) of water or juice. ; The drug is prescribed orally for adults and children over 15 years old at 500 mg (1 tab.) Up to 6 times / day. With severe pain and high temperature a single dose may be 1 g (2 tab.). The maximum daily dose is 3 g (6 tab.); Elderly patients are prescribed 500 mg (1 tab.) Up to 4 times / day. The maximum daily dose is 2 g (4 tab.). The interval between doses of the drug should be at least 4 hours. Regular adherence to the drug intake mode allows you to avoid a sharp rise in temperature and reduce the intensity of pain.; Duration of treatment (without consulting a doctor) should exceed 5 days when prescribed as an analgesic and more than 3 days as a febrifuge .;
Side effects
Allergic reactions: rarely - skin rash, bronchospasm, angioedema, the formation of a "aspirin triad" based on the hapten mechanism (a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone preparations); - nausea, vomiting, epigastric pain, diarrhea,gastrointestinal bleeding (vomiting such as "coffee grounds", black tarry stools), loss of appetite, increased activity of liver transaminases; From the urinary system: rarely - impaired kidney function; From the hematopoietic system: rarely - thrombocytopenia, anemia, leukopenia , hyperbilirubinemia. From the blood coagulation system: rarely - hemorrhagic syndrome (nose bleeding, gingival bleeding), an increase in blood clotting time. In recommended doses, the drug is usually well tolerated.; P The patient should be warned that in the event of adverse reactions, it is necessary to immediately stop taking the drug and inform the attending physician;
Overdose
Symptoms: in the initial stage of poisoning, symptoms of CNS arousal, dizziness, severe headache, decreased hearing, visual impairment, nausea, vomiting, increased breathing develop. Later comes the depression of consciousness up to coma, respiratory failure, impaired water and electrolyte metabolism.; Treatment: should induce vomiting or make a gastric lavage, appoint activated charcoal and a laxative. Treatment should be carried out in a specialized department .;
Interaction with other drugs
Acetylsalicylic acid enhances the toxicity of methotrexate, the effects of opioid analgesics, other NSAIDs, oral hypoglycemic drugs, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfonamides (including co-trimoxazole), I need them, and I need to do it. benzbromarone, sulfinpirazon), antihypertensive drugs and diuretics (spironolactone, furosemide); GCS, ethanol and ethanol-containing drugs increase the damaging effect e acetylsalicylic acid on the gastrointestinal mucosa, increase the risk of gastrointestinal bleeding.; Acetylsalicylic acid increases the concentration of digoxin, barbiturates and lithium drugs in the blood plasma.; Antacids containing magnesium and / or aluminum hydroxide, slow down and worsen the absorption of acetylsalicylic acid;
special instructions
Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in susceptible patients. With long-term use of the drug should be periodically complete blood count and analysis of fecal occult blood, to monitor the functional state of the liver.; Before surgery, to reduce bleeding during surgery and in the postoperative period, you should stop taking the drug for 5-7 days and notify the doctor.; Patients who comply with salt or low salt diet, it should be borne in mind that each tablet contains 388.5 mg (16.9 meq) of sodium.; Pediatric use; Children should not be given drugs containing acetylsalicylic acid, because in the case of viral infection increases the risk of Reye's syndrome. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, enlarged liver;