ACC Long effervescent pills 600mg 10 pcs
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Active ingredients
Acetylcysteine
Release form
Pills
Composition
1 effervescent tablet contains: active ingredient: acetylcysteine - 600.00 mg; excipients: citric acid - 625.00 mg; sodium bicarbonate - 327.00 mg; sodium carbonate - 104.00 mg; mannitol -72.80 mg; lactose - 70.00 mg; ascorbic acid - 75.00 mg; sodium cyclamate - 30.75 mg; sodium saccharinate dihydrate - 5.00 mg; sodium citrate dihydrate - 0.45 mg; Blackberry flavor "B" - 40.00 mg.
Pharmacological effect
Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of the mucopolysaccharide chains and cause the depolymerization of the mucoproteins of sputum, which leads to a decrease in the viscosity of the sputum. The drug retains activity in the presence of purulent sputum. It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidative radicals and, thus, neutralize them. In addition, acetylcysteine contributes to the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells against the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction. With prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.
Pharmacokinetics
Absorption is high. Metabolized rapidly in the liver to form a pharmacologically active metabolite, cysteine, as well as diacetylcysteine, cystine, and mixed disulfides. Oral bioavailability is 10% (due to the pronounced effect of the “first pass” through the liver). The time to reach the maximum plasma concentration is 1-3 hours. Communication with plasma proteins is 50%. Excreted by the kidneys as inactive metabolites (inorganic sulphates, diacetylcysteine). The half-life (T1 / 2) is about 1 hour, impaired liver function leads to a lengthening of T1 / 2 to 8 hours.It penetrates the placental barrier. Data on the ability of acetylcysteine to penetrate the blood-brain barrier and stand out with breast milk are not available.
Indications
Diseases of the respiratory system, accompanied by the formation of viscous sputum difficult to separate: • acute and chronic bronchitis, obstructive bronchitis; • tracheitis, laryngotracheitis; • pneumonia; • lung abscess; • bronchiectasis, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis; • cystic fibrosis; Acute and chronic sinusitis, inflammation of the middle ear (otitis media).
Contraindications
• hypersensitivity to acetylcysteine or other components of the drug; • peptic ulcer of the stomach and duodenum in the acute stage; • hemoptysis, pulmonary hemorrhage; • pregnancy; • lactation period; • children's age up to 14 years (for this dosage form); • lactase deficiency, lactose intolerance, glucose-galactose malabsorption. With care: a history of gastric ulcer and duodenal ulcer, bronchial asthma, obstructive bronchitis, hepatic and / or renal failure, histamine intolerance acetylcysteine affects histamine metabolism and can lead to the appearance of signs of intolerance, such as headache, vasomotor rhinitis, itching), esophageal varicose veins, adrenal disease Cove, hypertension.
Precautionary measures
There is no need for special precautions when destroying unused drug ACC Long. Tuba tightly closed after taking the pill!
Use during pregnancy and lactation
Data on the use of acetylcysteine during pregnancy and breastfeeding are limited, so the use of the drug during pregnancy is contraindicated. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.
Dosage and administration
Inside, after eating. Effervescent pills should be dissolved in one glass of water. Tablets should be taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours. The additional intake of liquid enhances the mucolytic effect of the drug.With short-term colds, the duration of treatment is 5-7 days. In chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a preventive effect. In the absence of other appointments, it is recommended to adhere to the following dosages: Mucolytic therapy: Adults and children over 14 years old: 1 tablet effervescent once a day (600 mg).
Side effects
According to the World Health Organization (WHO), adverse effects are classified according to their frequency of development as follows: very often (≥ 1/10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, < 1/100), rarely (≥1 / 10000, <1/1000) and very rarely (<1/10000); the frequency is unknown (the frequency of occurrence of events cannot be determined on the basis of available data). Allergic reactions are rare: itchy skin, rash, rash, urticaria; angioedema, lowering blood pressure, tachycardia; very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome). Respiratory system seldom: dyspnea, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma). On the part of the senses infrequently: tinnitus. From the gastrointestinal tract infrequently: stomatitis, pain in the abdomen, nausea, vomiting, diarrhea, dyspepsia. Others are very rare: headache, fever, isolated messages on the development of bleeding due to the presence of hypersensitivity reactions, reduction of platelet aggregation.
Overdose
Symptoms: with erroneous or deliberate overdose, there are such phenomena as diarrhea, vomiting, stomach pain, heartburn and nausea. Treatment: symptomatic.
Interaction with other drugs
With simultaneous use of acetylcysteine and antitussive drugs due to the suppression of the cough reflex, sputum stagnation may occur. With simultaneous use with antibiotics for oral administration (penicillins, tetracyclines, cephalosporins, etc.), their interaction with the thiol group of acetylcysteine is possible, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine should be at least 2 hours (except cefixime and loracarbef).Simultaneous use with vasodilating agents and nitroglycerin can lead to increased vasodilator action.
special instructions
Note for patents with diabetes: 1 effervescent tablet corresponds to 0.001 XE. When working with the drug it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances. When using acetylcysteine, very rarely there have been reported cases of severe allergic reactions, such as Stevens-Johnson syndrome and Lyell's syndrome. In the event of changes in the skin and mucous membranes, you should immediately consult a doctor, taking the drug should be stopped. Patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be administered with caution under systemic control of bronchial patency. Do not take the drug immediately before bedtime (it is recommended to take the drug before 18.00). Influence on the ability to drive vehicles, mechanisms Data on the negative effect of the drug ACC Long in recommended doses on the ability to drive vehicles, mechanisms do not.