Anvifen capsules 250 mg 20 pcs
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Active ingredients
Aminophenylbutyric acid
Release form
Capsules
Composition
Aminophenylbutyric acid hydrochloride 250 mg; Excipients: Hyprolosis — 2.0 mg, colloidal silicon dioxide — 8.0 mg, lactose — 86.5 mg, magnesium stearate — 3.5 mg. ), titanium dioxide (E171), water.
Pharmacological effect
Nootropic drug, facilitates GABA-mediated transmission of nerve impulses to the central nervous system (direct effects on GABA-ergic receptors). The tranquilizing effect is combined with an activating effect. It also has antiplatelet, antioxidant, and some anticonvulsant effects. It improves brain function by normalizing its metabolism and effect on cerebral blood flow (increases volumetric and linear speed, decreases vascular resistance, improves microcirculation, and has antiaggregant effect). Extends the latent period and shortens the duration and severity of nystagmus.; Does not affect the choline and adrenoreceptors. Reduces vasovegetative symptoms (including headache, feeling of heaviness in the head, sleep disturbances, irritability, emotional lability). In exchange, it increases physical and mental performance (attention, memory, speed and accuracy of sensory-motor reactions); reduces asthenia (improves well-being, increases interest and initiative (activity motivation)) without sedation or arousal. It helps to reduce feelings of anxiety, tension and anxiety, normalizes sleep.; In elderly people it does not cause CNS depression, a muscular-relaxing after-effect is most often absent.
Pharmacokinetics
Absorption and distribution; Absorption is high, penetrates well into all tissues of the body and through BBB (about 0.1% of the administered dose of the drug penetrates into the brain tissue, and in young and old people to a much greater extent). Evenly distributed in the liver and kidneys.; Metabolism and excretion; Metabolized in the liver - 80-95%, metabolites are not pharmacologically active. Does not accumulate. After 3 h, it begins to be excreted by the kidneys, while the concentration in the brain tissue does not decrease and is found for an additional 6 hours. About 5% is excreted by the kidneys in unchanged form, partly with bile.
Indications
- asthenic and anxiety-neurotic states; - stuttering, tics and enuresis in children; - insomnia and night anxiety in elderly patients; - Meniere's disease, dizziness associated with dysfunctions of the vestibular analyzer of various origins; - prevention of motion sickness with kinetozakh; - as part of the complex treatment of alcohol withdrawal syndrome for the relief of psychopathological and somatovegetative disorders.
Contraindications
- hypersensitivity to the drug; - pregnancy; - breast-feeding; - children's age up to 3 years.; With caution should use the drug for erosive and ulcerative lesions of the gastrointestinal tract, liver failure.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Dosage and administration
Inside after a meal 2-3-week courses.; Adults and children from 14 years on 250-500 mg 3 times / day (maximum daily dose of 2500 mg). Children from 3 to 8 years, 50-100 mg 3 times / day; from 8 to 14 years old - 250 mg 3 times / day; a single maximum dose in adults and children from 14 years old is 750 mg, in patients over 60 years old - 500 mg, in children under 8 years old - 150 mg, from 8 to 14 years - 250 mg.; With alcohol withdrawal syndrome - 250-500 mg 3 times / day and 750 mg for the night, with a gradual decrease in the daily dose to the usual for adults. 250 mg 3 times / day for 14 days.; For the prevention of motion sickness, 250-500 mg once a hour before the expected start of rolling or when First symptoms of seasickness. Anti-pumping action of the drug Anvifen; increases with increasing dose of the drug. At the onset of pronounced manifestations of motion sickness (vomiting, etc.), the appointment of the drug Anvifen; ineffective even in doses of 750-1000 mg.
Side effects
Possible: drowsiness, nausea, irritability, agitation, anxiety, dizziness, headache (at the first reception), allergic reactions.
Overdose
Symptoms: severe drowsiness, nausea, vomiting, fatty liver (taking more than 7 g), eosinophilia, lowering blood pressure, impaired renal function.
Interaction with other drugs
Extends and enhances the effect of hypnotic drugs, narcotic analgesics, antipsychotics, antiparkinsonian and antiepileptic drugs.
special instructions
With prolonged use, it is necessary to periodically monitor indicators of liver function and peripheral blood.; Impact on the ability to drive vehicles and control mechanisms; It is necessary to refrain from potentially dangerous activities that require high concentration of attention.