Betadine vaginal suppositories 14 pcs
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Active ingredients
Povidone-iodine
Release form
Suppositories
Composition
Active ingredient: Povidone-iodine. Concentration of active ingredient (mg): 200 mg
Pharmacological effect
Prolonged application of Betadine to extensive wounds and burns, as well as mucous membranes, can lead to the absorption of a significant amount of iodine. As a rule, the increase in the content of iodine in the blood caused by this quickly passes (the concentration returns to its initial level 7-14 days after the last use of the drug). In patients with normal thyroid function, increased iodine absorption does not cause any significant changes in its hormonal function. The absorption of povidone and its excretion by the kidneys depends on the average molecular weight (mixture). For substances with a molecular weight above 35,000-5,000, a delay in the body is possible, especially in the reticulohistiocytic system. The volume of distribution of iodine after absorption corresponds to approximately 38% of body weight (in kg), the time of biological half-life after vaginal administration is approximately 2 days. The normal total plasma level of iodine is approximately 3.8-6.0 mcg / dl, and the level of inorganic iodine is 0.01-0.5 mcg / dl. Iodine is excreted exclusively by the kidneys with a clearance of 15 to 60 ml of plasma per minute (normal limits: 100–300 mcg iodine per g creatinine).
Pharmacokinetics
The bactericidal effect of Betadine is associated with the release of free iodine, by an equilibrium reaction. Thus, the complex povidone-iodine is a depot of iodine, constantly releasing elemental iodine and ensuring a constant concentration of active free iodine. Free iodine reacts with oxidized SH- or OH- amino acid groups of enzymes and structural proteins of microorganisms, inactivating and destroying these enzymes and proteins. In this case, iodine becomes discolored, in connection with which the intensity of brown staining serves as an indicator of the effectiveness of the drug. After bleaching, reapplication is possible. This relatively non-specific mechanism of action explains Betadine’s wide spectrum of action on pathogenic pathogens in humans: gram-positive and gram-negative bacteria, Gardenerella vag. Treponema pall. , Chlamydiae, mycoplasma, protozoa (including Trichomonas), viruses (including the herpes virus and HIV), fungi (for example, of the genus Candida) and spores.Due to this mechanism of action, the development of resistance to the drug, including secondary resistance, with long-term use is not expected. Betadine solution is soluble in water and is easily washed off.
Indications
Vaginal suppositories are used for: acute and chronic inflammatory diseases of the vagina, mixed infections, nonspecific infections, fungal infections, infections caused by Trichomonas, gardnerella, chlamydia, genital herpes
Contraindications
Individual hypersensitivity to iodine, hyperthyroidism, herpetiform dermatitis dermatitis, before the introduction of radioactive iodine.
Precautionary measures
Eye contact should be avoided. At occurrence of hypersensitivity reactions to iodine (itching, hyperemia), the drug should be discontinued. In cases of asymptomatic hyperfunction of the thyroid gland and other diseases of the thyroid gland, especially in the elderly, is used only as directed by a physician. It is necessary to monitor the function of the thyroid gland in newborns and children fed with breast milk, whose mothers used povidone-iodine in suppositories. For more information on the instructions and price of candles "Betadine" look in our blogs.
Use during pregnancy and lactation
Betadine is contraindicated from the third month of pregnancy and breastfeeding. The first two months, the application is possible with caution only for the purpose and under the supervision of a physician.
Dosage and administration
Vaginal suppositories: In acute cases, the disease is prescribed twice a day, one suppository, injecting deep into the vagina, for 7 days. In the case of a subacute and chronic course of the disease, usually, within 14 days, one suppository is administered per day, introducing it into the vagina at bedtime. Depending on the nature of the infection and the course of the disease, the course of treatment may be extended.
Side effects
Perhaps a local manifestation of increased sensitivity to iodine (itching, hyperemia), which requires discontinuation of the drug.
Overdose
Symptoms: anuria, circulatory failure, laryngeal edema, pulmonary edema, metabolic disorders. Treatment: the immediate introduction of food products containing starch or protein (for example, a solution of starch in water or milk).Gastric lavage with 5% sodium thiosulfate solution (or intravenous administration of 10 ml of 10% sodium thiosulfate solution) at three-hour intervals as needed. In addition, careful clinical monitoring of thyroid function should be established to rule out early detection of iodine-induced hyperthyroidism.
Interaction with other drugs
The combined use of Betadine and hydrogen peroxide, as well as enzyme preparations containing silver and toluidine, for the treatment of wounds or antiseptic preparations, leads to a mutual decrease in efficiency. Povidone-iodine cannot be used in combination with mercury preparations due to the risk of formation of alkaline mercury iodide. The drug can react with proteins and unsaturated organic complexes, so the effect of povidone-iodine can be compensated by increasing its dose. Prolonged use, especially on large surfaces, in patients receiving lithium preparations should be avoided. Incompatibility: Povidone-iodine is incompatible with reducing agents, salts of alkaloids, tannic acid, salicylic acid, silver, salts of mercury and bismuth, toluidine, hydrogen peroxide
special instructions
Since it is impossible to exclude the development of hyperthyroidism, long-term (more than 14 days) use of Betadine or its use in large quantities on large surfaces (more than 10% of the surface) in patients (especially in elderly) with latent thyroid function disorders, is acceptable only after a careful comparison of the expected benefit and possible risk. These patients should be monitored to detect early signs of hyperthyroidism and to properly study the function of the thyroid gland, even after stopping the use of the drug (for up to 3 months). Betadine use can reduce the absorption of iodine by the thyroid gland, which can affect the results of some studies and procedures (scintigraphy of the thyroid gland, determination of protein-bound iodine, and diagnostic procedures using radioactive iodine), with which planning for the treatment of diseases of the thyroid gland with iodine may become impossible. After discontinuation of Betadine, it is necessary to sustain an interval of at least 1 to 4 weeks.The oxidative effect of Betadine can lead to false-positive results of various diagnostic tests (for example, detection of occult blood in the feces or urine and glucose in the urine using toluidine and guaiac resins). The oxidative properties of Betadine can cause corrosion of metals, whereas plastic and synthetic materials are usually not sensitive to povidone-iodine. In some cases, there may be a color change, which is usually restored. Betadine solution is easily removed with textile and other materials with warm water and soap. Stubborn stains should be treated with ammonia or sodium thiosulfate. Use in pediatrics: In newborns and in children under the age of 6 months, the use of Betadine is permissible only under strict indications. If necessary, you should monitor the function of the thyroid gland.