Caffeine sodium benzoate injection injection ampoules 20% 1ml N10
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Active ingredients
Caffeine
Release form
Solution
Composition
1 ml contains: Caffeine sodium benzoate 200 - mg.
Pharmacological effect
Psychogogic and analeptic, a derivative of methylxanthine. Competitively blocks the central and peripheral A1 and A2 adenosine receptors. Inhibits PDE activity in the central nervous system, heart, smooth muscle organs, skeletal muscles, adipose tissue, promotes the accumulation of cAMP and cGMP in them (this effect is observed when used only in high doses). Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the center of n.vagus, and has a direct stimulating effect on the cerebral cortex. In high doses, it facilitates interneuronal conduction in the spinal cord, enhancing spinal reflexes. It improves mental and physical performance, stimulates mental activity, physical activity, shortens the reaction time, temporarily reduces fatigue and drowsiness. In small doses, the effect of stimulation prevails, and in large doses - the effect of suppression of the nervous system. It stimulates and deepens the breath. Usually it has a positive in-, chrono, batmo-and dromotropic effect (since the effect on the CVS is the direct stimulating effect on the myocardium and the simultaneous stimulating effect on the n.vagus centers, the resulting effect depends on the prevalence of one or another action). Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to the expansion of heart vessels, skeletal muscles and kidneys, while the tone of cerebral arteries increases (causes narrowing of the brain vessels, which is accompanied by a decrease in brain blood flow and oxygen pressure in the brain). Blood pressure changes under the action of vascular and cardiac mechanisms of caffeine influence: in normal baseline blood pressure, caffeine does not change or slightly increase it, and in case of arterial hypotension It has a spasmolytic effect on smooth muscles (including bronchodilating effect), and on striated muscles - stimulating. It increases the secretory activity of the stomach. It has a moderate diuretic effect, which is caused by a decrease in the reabsorption of sodium ions and water in the proximal and distal renal tubules, also vasodilation of the kidneys and an increase in filtration in the renal glomeruli. Reduces platelet aggregation and the release of histamine from mast cells. Increases basal metabolism: increases glycogenolysis increases lipolysis.
Pharmacokinetics
Data on the pharmacokinetics of the drug is not provided.
Indications
Diseases accompanied by inhibition of the central nervous system, functions of the cardiovascular and respiratory systems (including poisoning with opioid analgesics, infectious diseases), spasms of cerebral vessels, reduced mental and physical performance, drowsiness.
Contraindications
Arterial hypertension, organic diseases of the cardiovascular system (including pronounced atherosclerosis), glaucoma, increased excitability, sleep disturbances, old age.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
C caution is used during pregnancy.
Dosage and administration
Injected s / c or take inside. Adults - 100-200 mg 2-3 times / day; children - 25-100 mg 2-3 times / day.
Side effects
From the side of the central nervous system: sleep disturbance, agitation, anxiety; with prolonged use may be addictive. From the cardiovascular system: tachycardia, increased blood pressure, arrhythmias. From the digestive system: nausea, vomiting.
Overdose
Data overdose of the drug is not available.
Interaction with other drugs
With simultaneous use, the effect of hypnotic drugs and drugs for anesthesia is reduced. With simultaneous use, it is possible to increase the effect of analgesics, antipyretic drugs, salicylamide, naproxen. CYP1A2. With the simultaneous use of adenosine, caffeine reduces the increased heart rate and blood pressure changes caused by infusion of adenosine; reduces vasodilation caused by the action of adenosine. With simultaneous use, it is possible to increase the bioavailability, absorption rate and plasma concentration of acetylsalicylic acid. With simultaneous use, meksiletin reduces the clearance of caffeine and increases its concentration in plasma, apparently due to inhibition of metabolism of caffeine in the liver .Metoxene reduces the excretion of caffeine from the body with the possible enhancement of its effect and the development of toxic action. Due to the induction of microsomals Liver enzymes under the influence of phenytoin, with its simultaneous use, accelerate metabolism and excretion of caffeine. Fluconazole and terbinafine cause a moderate increase in plasma caffeine concentration,ketoconazole - less pronounced. The most pronounced increase in AUC and decrease in clearance are observed with the simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemido acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin. When used simultaneously, caffeine accelerates the absorption of ergotamine.
special instructions
There are no special instructions.